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577 Possible Causes for Disturbance of Growth, Splenomegaly

  • Thalassemia

    Approach to the adult patient with splenomegaly and other splenic disorders. . Accessed June 14, 2016. Splenomegaly. Merck Manual Professional Version. .[mayoclinic.org] Because of the decreased, and often pathological erythrocytes, hypoxia becomes clinically relevant as growth disturbances and trophic skin changes show in child age. α-Thalassemia[lecturio.com] As hypersplenism may cause worsening anemia, retarded growth and mechanical disturbance from the large spleen, splenectomy is a relevant aspect of the management of thalassemia[doi.org]

  • Progressive Familial Intrahepatic Cholestasis

    […] cholesterol cholelithiasis • MDR3 disease PFIC3 presents during infancy with pruritus, jaundice, pale stools, hepatomegaly, or complications of portal hypertension, such as splenomegaly[basicmedicalkey.com] Both patients had normal gamma-glutamyl transpeptidase levels, but showed severe pruritus with sleep disturbance, cholestasis, jaundice and growth failure.[ncbi.nlm.nih.gov] […] jaundice Dark urine Physical See the list below: Pruritus Scratching Cutaneous mutilation Irritability in infants Jaundice Scleral icterus Cutaneous jaundice Hepatomegaly Splenomegaly[emedicine.medscape.com]

  • Congenital Generalized Lipodystrophy Type 2

    Hepatomegaly and splenomegaly may be found during the postnatal examination and may provoke umbilical prominence or even an umbilical hernia.[symptoma.com] Complications include hypertrophic cardiomyopathy, a fatty liver with hepatic dysfunction, muscular hypertrophy, a number of endocrine disturbances (accelerated growth in[orpha.net] Some individuals may also have an abnormally enlarged spleen (splenomegaly). Hepatomegaly is often noticed during infancy.[rarediseases.org]

  • Hemochromatosis

    Regression on SF revealed significant associations: TS; male sex; age; GGT; transfusion units (positive); and splenomegaly (negative) (p 0.0001, 0.0016, 0.0281, 0.0025, 0.0001[ncbi.nlm.nih.gov] The main adverse effects are inflammatory reactions at the sites of injection, visual and auditory disturbances, bone growth disturbances, and allergic reactions, including[physio-pedia.com] Here we report the case of a 16-year-old Chinese boy, who was admitted with hepatalgia, jaundice, hyperpigmentation, and splenomegaly to our hospital.[ncbi.nlm.nih.gov]

  • Leukoerythroblastic Anemia

    Symptoms and Signs Myeloid metaplasia may result in splenomegaly, particularly in patients with storage diseases.[merckmanuals.com] Investigators concluded that bone marrow transplant offered a cure of both the bone marrow failure and the metabolic disturbances.[aafp.org] The French authors, Emil-Weil and Clerc, 1 in 1902, and Vaquez and Aubertin, 2 in 1904, first discussed a syndrome characterized by splenomegaly due to myeloid change and[jamanetwork.com]

  • Rheumatoid Arthritis

    It is extremely rare for RA to present as FS or develop after initially presenting as neutropaenia and splenomegaly.[ncbi.nlm.nih.gov] Patients with rheumatoid arthritis and suffering with anemia have a decreased sensitivity of bone marrow erythroblasts to interleukin‐3, which has hematopoietic growth‐promoting[doi.org] Other: thyroid disorders, osteoporosis, depression, splenomegaly.[patient.info]

  • Infective Endocarditis

    This score includes clinical, epidemiological (male, fever, splenomegaly, clubbing, vascular disease and stroke) and biological criteria (Leucocytes 10,000/mm3, sedimentation[ncbi.nlm.nih.gov] Bacteriophages and their host ranges are extremely specific for certain bacteria, thus they do not disturb the host organism and intestinal microflora unlike antibiotics.[en.wikipedia.org] Additional findings may include splenomegaly, gallop or arrhythmia, pericardial or pleural rubs, rales, pallor, acute septic monoarticular arthritis or delirium.[symptoma.com]

  • Acute Lymphoblastic Leukemia Type L1

    The child redeveloped splenomegaly and fever, and then suffered an acute decompensation with hypoxemia, tachypnea, splenomegaly, and cardiac gallop.[ncbi.nlm.nih.gov] Endocrine: Disturbances of growth and hormonal axes are seen in patients with ALL, particularly those who require radiation therapy to the CNS.[clinicaladvisor.com] Other manifestations include bone pain and arthritis, hepatomegaly, splenomegaly, lymphadenopathy, extramedullary masses located in the abdomen (compression of neighboring[symptoma.com]

  • Congenital Generalized Lipodystrophy Type 1

    Hepatomegaly and splenomegaly may be found during the postnatal examination and may provoke umbilical prominence or even umbilical hernia.[symptoma.com] Complications include hypertrophic cardiomyopathy, a fatty liver with hepatic dysfunction, muscular hypertrophy, a number of endocrine disturbances (accelerated growth in[orpha.net] […] has characteristic features like hepatomegaly or an enlarged liver which arises from fatty liver and may lead to cirrhosis , muscle hypertrophy , lack of adipose tissue , splenomegaly[en.wikipedia.org]

  • Myelodysplasia

    Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which[ncbi.nlm.nih.gov] Sometimes with growth, children with this condition may develop foot weakness or bowel and bladder sphincter disturbances.(13) Figure 2 shows a normal spine and the types[go.galegroup.com] We present a 2-year-old boy with splenomegaly, leukocytosis, thrombocytopenia, anemia, and excess myeloblasts with easily seen Auer rods, and marked dysgranulopoiesis and[ncbi.nlm.nih.gov]

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