Diurnal Fluctuations of Symptoms: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Diurnal Fluctuations of Symptoms

Aromatic L-Amino Acid Decarboxylase Deficiency

Diurnal fluctuation or improvement of symptoms after sleep were noted in half of the patients. Treatment response was variable. [ncbi.nlm.nih.gov]

In some disorders, diurnal fluctuation of symptoms may also be present. [invitae.com]

Parkinson Disease Type 2

Paralysis agitans of early onset with marked diurnal fluctuation of symptoms. Neurology 1973;23:239–244. 23. Ishikawa A, Tsuji S. [e-jmd.org]

It differs from classic Parkinson disease by early DOPA-induced dyskinesia, diurnal fluctuation of the symptoms, sleep benefit, dystonia and hyper-reflexia. [genecards.org]

Some patients describe their symptoms to improve after sleep, although diurnal fluctuations seem to level out as the disease progresses. [symptoma.com]

Adult-Onset Cervical Dystonia Type DYT23

Hanihara T, Inoue K, Kawanishi C et al (1997) 6-Pyruvoyl-tetrahydropterin synthase deficiency with generalized dystonia and diurnal fluctuation of symptoms: a clinical and [link.springer.com]

fluctuation of symptoms, and a dramatic and sustained response to levodopa [ 36 ]. [neupsykey.com]

These symptoms show marked diurnal fluctuations, worsening through the day and almost absent in the early morning. [misc.medscape.com]

Pallidopyramidal Syndrome

Paralysis agitans of early onset with marked diurnal fluctuation of symptoms. [ncbi.nlm.nih.gov]

Idiopathic dystonia-parkinsonism with marked diurnal fluctuation of symptoms. Ann Neurol 1985;17(1):39–45. 18. [synapse.koreamed.org]

Tyrosine Kinase 2 Deficiency

fluctuation of symptoms: a clinical and molecular study. [ncbi.nlm.nih.gov]

Kawanishi C, Sugiyama N, Miyakawa T, Onishi H, Yamada Y, Osaka H, Kosaka K, Iwabuchi K, Owada M. 6-Pyruvoyl-tetrahydropterin synthase deficiency with generalized dystonia and diurnal [ncbi.nlm.nih.gov]

Autosomal Dominant Spastic Paraplegia Type 31

fluctuation of symptoms, and a dramatic response to levodopa therapy. [11] Parkinsonian features may appear later in the course of the disease and in adult family members [movementdisorders.org]

[…] dysarthria, ophthalmoplegia, hypometric saccades, slow tongue Borderline TCC and cerebellar atrophy Dopa-responsive dystonia (DRD) is characterized by childhood-onset dystonia, diurnal [movementdisorders.org]

Dystonia

Segawa's syndrome or dopa-responsive dystonia is a rare hereditary disorder characterized by progressive dystonia of childhood onset, diurnal fluctuation of symptoms and complete [ncbi.nlm.nih.gov]

Here, we report the case of a male patient with genetically confirmed Segawa disease and atypical presentations including no diurnal symptom fluctuation and insufficient response [ncbi.nlm.nih.gov]

This form is also known as Segawa's disease and shows an excellent and sustained response to low doses of levodopa.29 Typically, there is a diurnal fluctuation of symptoms [jnnp.bmj.com]

Infantile Dystonia - Parkinsonism

Hanihara, T. et al. 6-Pyruvoyl-tetrahydropterin synthase deficiency with generalized dystonia and diurnal fluctuation of symptoms: a clinical and molecular study. Mov. [nature.com]

At least 50% of patients have diurnal fluctuation with marked progression of their symptoms toward the end of the day and relief after sleep. [genedx.com]

Dopa-Responsive Dystonia (DRD) is a treatable neurological condition which can present with a variety of symptoms ranging from dystonia, spastic paraparesis, and proximal [genedx.com]

Primary Dystonia Type DYT2

Several forms have a disorder of dopamine metabolism, diurnal fluctuation of symptoms and a sustained response to levodopa. [onlinelibrary.wiley.com]

Scoliosis

Oppenheim Disease

These symptoms show marked diurnal fluctuations, worsening through the day and almost absent in the early morning. [emedicine.medscape.com]

However, this fluctuation decreases with age in the late teens, and is no longer apparent in early adulthood, when symptoms become static. [emedicine.medscape.com]

Primary Torsion Dystonia

These symptoms show marked diurnal fluctuations, worsening through the day and almost absent in the early morning. [emedicine.medscape.com]

However, this fluctuation decreases with age in the late teens, and is no longer apparent in early adulthood, when symptoms become static. [emedicine.medscape.com]

Endogenous Depression

A positive correlation was found between the number of anancastic personality features and the following symptoms: agitation, anxiety, diurnal fluctuation, seasonal variation [ncbi.nlm.nih.gov]

The pattern of the anancastic symptoms was rather uniform; aggressive obsessions, mostly in the form of suicidal and homicidal obsessions, were present in more than two thirds [ncbi.nlm.nih.gov]

Iridocorneal Endothelial Syndrome

In patients with consistent daily episodes of transient blurry vision, clinicians should suspect a large diurnal IOP fluctuation with high peak IOP. [ncbi.nlm.nih.gov]

If symptoms and signs are unilateral, iridocorneal endothelial syndrome should be included in the differential diagnosis and corneal specular microscopy should be obtained [ncbi.nlm.nih.gov]

IOP oculus dexter remained within normal limits with clear cornea and stable visual acuity throughout the diurnal measurements. [ncbi.nlm.nih.gov]

Early-Onset Generalized Torsion Dystonia

These symptoms show marked diurnal fluctuations, worsening through the day and almost absent in the early morning. [emedicine.medscape.com]

However, this fluctuation decreases with age in the late teens, and is no longer apparent in early adulthood, when symptoms become static. [emedicine.medscape.com]

Alopecia - Hypogonadism - Extrapyramidal Syndrome

fluctuation; hereditary progressive dystonia with marked diurnal fluctuation Related symptoms: Hearing impairment Scoliosis Ataxia Hypertension Talipes equinovarus SOURCES [mendelian.co]

[…] variation, dystonia-parkinsonism with diurnal fluctuation, segawa syndrome, autosomal dominant, dystonia, dopa-responsive, autosomal dominant, dopa-responsive dystonia, autosomal [mendelian.co]

[…] dominant Related symptoms: Autosomal recessive inheritance Autosomal dominant inheritance Pica Hearing impairment Scoliosis SOURCES: OMIM MONDO DOID GARD ORPHANET More info [mendelian.co]

Dentatorubral-Pallidoluysian Atrophy

Paralysis agitans of early onset with marked diurnal fluctuation of symptoms. Neurology. 1973 Mar;23(3):239–244. [ncbi.nlm.nih.gov]

Lambert-Eaton Syndrome

She experienced marked diurnal fluctuation of symptoms, with them being worse in the afternoon and when she was fatigued. [synapse.koreamed.org]

Two months after symptom onset she developed proximal limb weakness and had difficulty in climbing stairs and swallowing. [synapse.koreamed.org]

Autosomal Dominant Spastic Paraplegia Type 29

Not all patients exhibited diurnal fluctuations in their symptoms [11-13]. [nanopdf.com]

Factitious Disorder

Her symptoms had no diurnal fluctuations and had onset in adolescence. She also noted intermittent muscle twitches. [empr.com]

Torsion Dystonia Type 7

These symptoms show marked diurnal fluctuations, worsening through the day and almost absent in the early morning. [emedicine.medscape.com]

However, this fluctuation decreases with age in the late teens, and is no longer apparent in early adulthood, when symptoms become static. [emedicine.medscape.com]

Primary Torsion Dystonia 6

These symptoms show marked diurnal fluctuations, worsening through the day and almost absent in the early morning. [emedicine.medscape.com]

However, this fluctuation decreases with age in the late teens, and is no longer apparent in early adulthood, when symptoms become static. [emedicine.medscape.com]

Hyperphenylalaninemia

Diurnal fluctuation of the symptoms (increase of symptoms in the evening and lessening in the morning) is characteristic of the condition. [invitae.com]

Affected individuals can have any of the following symptoms with diurnal fluctuations: speech and motor delays, learning disabilities and mental retardation, hypotonia, weakness [invitae.com]

Painful Ophthalmoplegia

There is no diurnal fluctuation. There are no other symptoms. She presented with similar symptoms two years previously. [eanpages.org]

Juvenile Paralysis Agitans of Hunt

Patients with parkin mutations may have atypical clinical features such as dystonia at onset and marked diurnal symptom fluctuation; the disorder may bear some relationship [neupsykey.com]

[…] without marked diurnal fluctuations and without heritance, but with a steady progress in spite of a certain answer on levodopa treatment. [kundoc.com]

In addition, diurnal fluctuations in symptomatology and marked sleep benefit may occur in early-onset cases, even prior to the introduction of levodopa (11, 14, 32). [bioscience.org]

Congenital Slow-Channel Myasthenic Syndrome Type 4A

Diurnal fluctuation of the symptoms was noted in 8 patients and disease progression was observed in 9 of them (41%). [degruyter.com]

Lacrimal Gland Disorder

fluctuation and exacerbation of symptoms during specific activities or environmental conditions. [emedicine.medscape.com]

[…] sensation Lid irritation and swelling Photophobia Ocular fatigue Mucoid discharge Dry eyes vs Sjögren syndrome Two important clues that the patient may have dry eyes include diurnal [emedicine.medscape.com]

Dopamine Beta-Hydroxylase Deficiency

No diurnal fluctuation in the symptoms was observed. [clinchem.aaccjnls.org]

Corticotroph Pituitary Adenoma

Even if cabergoline could restore normal 24-hour cortisol production and disappearance of Cushing’s symptoms, there were no detailed studies as to whether diurnal fluctuations [csrf.net]

Torticollis

This disorder typically presents with gait disturbance caused by foot dystonia, later development of parkinsonism, and diurnal fluctuation of symptoms (aggravation of symptoms [ncbi.nlm.nih.gov]