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101 Possible Causes for Down Syndrome, Pansystolic Murmur

  • Endocardial Cushion Defect

    Down syndrome with endocardial cushion defect is a challenging diagnosis for parents as well as members of the health care team.[ncbi.nlm.nih.gov] Identification of a heart murmur (most likely pansystolic, but also ejection systolic or apical mid-diastolic) during cardiac auscultation can raise sufficient clinical suspicion[symptoma.com] Abstract The commissure between the anterior and medial leaflets of the tricuspid valve is commonly absent in Down's syndrome without endocardial cushion defect (19 of 28[ncbi.nlm.nih.gov]

  • Ventricular Septal Defect

    Abstract Medical records of 118 newborn infants with Down's syndrome were reviewed to document the types of congenital heart disease (CHD) in those having echocardiography[doi.org] Small lesions with minimal shunting may be asymptomatic, however may have a loud harsh pansystolic murmur heard on precordial ausculation over the left sternal border 10 .[radiopaedia.org] We report a case of Morgagni hernia occupying the anterior mediastinum and right hemithorax in a male infant with Down syndrome, who also had a perimembranous ventricular[ncbi.nlm.nih.gov]

  • Congestive Heart Failure

    In AHF caused by acute coronary syndromes, nitrates are favoured over SNP as SNP may cause ‘coronary steal syndrome’. 77 , 78 10.3.3 Nesiritide.[doi.org] A grade 3/6 pansystolic murmur was heard, and echocardiography revealed severe mitral regurgitation with a hyperechoic obstacle on the posterior mitral valve leaflet, consistent[ncbi.nlm.nih.gov] Controlled trials with SNP in AHF are lacking and its administration in AMI has yielded equivocal results. 76 SNP should be tapered down to avoid rebound effects.[doi.org]

  • Cor Pulmonale

    Alveolar Hypoventilation and Cor Pulmonale Associated with Chronic Airway Obstruction in Infants with Down syndrome. Clinical Pediatrics. 21(1); 25-29.[asrn.org] On cardiovascular system examination, there was loud pulmonic component of second heart sound along with a pansystolic murmur suggestive of tricuspid regurgitation at a left[ijem.in] (Down, Treacher Collins) Neuromuscular disorders: Duchenne muscular dystrophy Chest wall deformities Commonly Associated Conditions Pulmonary vascular abnormalities Collagen[unboundmedicine.com]

  • Cardiomyopathy

    Disease Screening Program Breathing Cystic Fibrosis D Neuroscience Deep Brain Stimulation Program Dental Dermatology Neuroscience Developmental Pediatrics Digestive Health Down[childrenscolorado.org] Down syndrome patients with congenital heart defect have higher CD prevalence as compared to patients without congenital heart defect, and CD prevalence in Down syndrome patients[doi.org] […] tension changes in myocardial gene expression sarcomeres laid down in parallel increased left ventricular thickness decreased left ventricular size diastolic dysfunction[amboss.com]

  • Atrial Septal Defect

    McMahon, Congenital Heart Disease in Down Syndrome, Advances in Research on Down Syndrome, 10.5772/intechopen.71060, (2018).[doi.org] Characterized by palpable cardiac thrill and audible pansystolic murmur on both sides of the chest at birth, accompanied by exercise intolerance and developing dyspnea at[medical-dictionary.thefreedictionary.com] A pansystolic murmur of “mitral” regurgitation is characteristic of the patient with a primum ASD.[circ.ahajournals.org]

  • Myocardial Infarction

    Serum screening for Down’s syndrome between 8 and 14 weeks of pregnancy for the International Prenatal Screening Research Group.[clinchem.org] Down syndrome patients with congenital heart defect have higher CD prevalence as compared to patients without congenital heart defect, and CD prevalence in Down syndrome patients[dx.doi.org] Point-of-care time-resolved immunofluorimetric assay for human pregnancy-associated plasma protein A: use in first-trimester screening for Down’s syndrome.[clinchem.org]

  • Large Ventricular Septal Defect

    Specific risk factors for a VSD include being of Asian heritage, having a family history of congenital heart disease, and having other genetic disorders, such as Down syndrome[healthline.com] Classically, a VSD causes a pathognomonic holo- or pansystolic murmur. Auscultation is generally considered sufficient for detecting a significant VSD.[en.wikipedia.org] Ventricular septal defects often accompany genetic syndromes, including Down syndrome. But most scientists believe that genetic abnormalities are only half of the story.[zofranlegal.com]

  • Mitral Valve Prolapse

    People with Down syndrome also often have mitral valve prolapse.[ctds.info] A 33-year-old man was investigated for dyspnea on exertion and the presence of a pansystolic murmur.[ncbi.nlm.nih.gov] Some forms of mitral valve prolapse seem to be passed down through families (inherited).[nlm.nih.gov]

  • Atrial Myxoma

    About 10% of myxomas are passed down through families (inherited), as in Carney syndrome, where several other abnormalities are observed, such as skin myxomas, pigmentation[en.wikipedia.org] This time in addition to her- mitral stenotic murmur she also had a grade II pansystolic murmur al the apex.[jpgmonline.com] Lying down typically causes the myxoma to move away from the valve and relieves the symptoms.[merckmanuals.com]

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