Downbeat Nystagmus: Causes & Reasons

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Possible Causes for Downbeat Nystagmus

Spinocerebellar Ataxia Type 5

The phenotype is characterized by a purely cerebellar syndrome with a downbeat nystagmus occurring prior to the development of other features. [ncbi.nlm.nih.gov]

Two of the six demonstrated downbeat nystagmus in the primary position on ophthalmoscopy, and one of these and one other displayed upwards gaze evoked nystagmus on upgaze. [jnnp.bmj.com]

Arnold-Chiari Malformation

The Arnold-Chiari malfomation is typically associated with downbeat nystagmus. [ncbi.nlm.nih.gov]

Differential Diagnosis of downbeating nystagmus Other causes of constant downbeating nystagmus that should generally be considered are migraine, paraneoplastic cerebellar [dizziness-and-balance.com]

Eye movement recordings in two patients with Arnold-Chiari malfomation type 1 showed, in addition to downbeat and gaze evoked nystagmus, intermittent nystagmus of skew. [ncbi.nlm.nih.gov]

Brain Stem Disorder

nystagmus and oculomyoclonus (medullary involvement) See Clinical Presentation for more detail. [emedicine.medscape.com]

Sensory loss in the face (involvement of the trigeminal nucleus) Dysphagia and/or dysphonia from lower cranial nerve involvement (commonly IX and X) Long tract signs Ataxia Downbeating [emedicine.medscape.com]

Central Positional Vertigo

Downbeat nystagmus is the most common form of central vestibular nystagmus and results from defective vertical gaze holding that allows for a pathologic upward drift of the [aao.org]

The actual pathophysiology causing the downbeating nystagmus is not well understood at this point, but it is thought that the downbeating nystagmus results from an imbalance [mhmedical.com]

[…] all dealt with elsewhere except for downbeating nystagmus on lateral gaze. [dizziness-and-balance.com]

Spinocerebellar Ataxia Type 6

We report two siblings with spinocerebellar ataxia type 6 (SCA 6), both showing downbeat nystagmus (DBN) as a predominant clinical feature. [ncbi.nlm.nih.gov]

Abstract To investigate the frequency of positioning nystagmus in degenerative ataxic disorders, we examined downbeat positioning nystagmus (DPN) in 25 patients with spinocerebellar [ncbi.nlm.nih.gov]

In analysis of CAG repeat length in patients with different types of nystagmus, CAG repeat length was the longest when both upbeat and downbeat nystagmus existed (P < 0.01 [ncbi.nlm.nih.gov]

Hereditary Nystagmus

Upbeat jerk nystagmus. Upbeat nystagmus is less frequent than downbeat nystagmus. [neuroophthalmology.ca]

Downbeating nystagmus can be elicited by the head-shaking test. [tchain.com]

Consequently, the patient is best managed with treatments directed towards the underlying disorder.[6] Peripheral Vestibular Nystagmus Downbeat Nystagmus Downbeat nystagmus [webeye.ophth.uiowa.edu]

Pineal Gland Neoplasm

ICD.Codes ICD-10-CM (2016) Chapter 2 Section C73-C75 Code C75.3 BILLABLE Billable Code Billable codes are sufficient justification for admission to an acute care hospital when used a principal diagnosis. | ICD-10 from 2011 - 2016 C75.3 is a billable ICD code used to specify a diagnosis of malignant neoplasm of pineal[…] [icd.codes]

Phencyclidine Intoxication

Abstract Phencyclidine (PCP) is a dissociative anesthetic whose abuse is a growing problem. Historically, its effects have been considered remarkably like those of the schizophrenic state, but in vitro and in vivo neuropharmacologic data are somewhat inconsistent with the dopaminergic hypothesis of schizophrenia. The[…] [ncbi.nlm.nih.gov]

Autosomal Recessive Spinocerebellar Ataxia Type 17

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [psychology.wikia.com]

[…] neurologic reflexes ) Chromosome 16q SCA5 ( SPTBN2 ) 3rd - 4th decade (10-68) >25 years Pure cerebellar Chromosome 11 SCA6 [ 7 ] ( CACNA1A ) 5th - 6th decade (19-71) >25 years Downbeating [thefullwiki.org]

[…] neurologic reflexes ) Chromosome 16q SCA5 ( SPTBN2 ) 3rd - 4th decade (10-68) >25 years Pure cerebellar Chromosome 11 SCA6 [6] ( CACNA1A ) 5th - 6th decade (19-71) >25 years Downbeating [psychology.wikia.com]

Pineal Gland Dysfunction

Linda S. Noelker, PhD, joined the Benjain Rose Institute in 1974 as an applied aging researcher and is currently the Senior Vice President for Planning and and Organizational Resources. In that capacity, she oversees the Research Institute and the Institutional Advancement and the Advocacy and Public Policy[…] [books.google.com]

Autosomal Recessive Spinocerebellar Ataxia 8

Clinically they have a coarse gaze-evoked nystagmus, downbeat nystagmus on lateral gaze, and poor visual suppression (Gomez et al, 1997). [tchain.com]

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [psychology.wikia.com]

According to Baloh and others (1997), EA2 is characterized by a progressive ataxia with interictal rebound nystagmus evoked by gaze, as well as downbeating nystagmus. [tchain.com]

Syringomyelia - Syringobulbia

On lateral gaze, jerk nystagmus in the direction of the gaze and downbeat nystagmus were found. [jnnp.bmj.com]

Nystagmus (irregular eye movements; typically, so-called "downbeat nystagmus"). [disabled-world.com]

Autosomal Recessive Spinocerebellar Ataxia 18

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [wikidoc.org]

Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord 2009;24:1290–1295. 28. [e-jmd.org]

[…] neurologic reflexes ) Chromosome 16q SCA5 ( SPTBN2 ) 3rd–4th decade (10–68) >25 years Pure cerebellar Chromosome 11 SCA6 [12] ( CACNA1A ) 5th–6th decade (19–71) >25 years Downbeating [en.wikipedia.org]

Infantile-Onset Autosomal Recessive Non-Progressive Cerebellar Ataxia

[…] by vision, downbeat nystagmus on lateral gaze, can seen in SCA 6. [explainmedicine.com]

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [en.wikipedia.org]

Identification of new genes Spinocerebellar ataxia autosomal recessive type 10: A new form of pure recessive ataxia accompanied by downbeat nystagmus and lower motor neuropathy [wjgnet.com]

Spinocerebellar Ataxia Type 19

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [wikidoc.org]

Spontaneous downbeat nystagmus was another consistent feature, and saccadic velocity was within normal limits. [35], [36] In a family initially classified as autosomal dominant [annalsofian.org]

Tremor Head or Hand: SCA 8, 12, 15-16, 19, 27 Palatal: SCA 20 Normal lifespan: SCA 6, 11 Eye 60 Slow saccades Early/prominent: SCA 2, 7 Late: SCA 1, 3, 28 Very rarely: SCA 6 Nystagmus [neuromuscular.wustl.edu]

Cerebellar Ataxia with Peripheral Neuropathy Type 2

nystagmus, cranial nerve palsies involving 9,10,12 or signs and symptoms of Syringomyelia Investigations include MRI scan for diagnosis and classification. [medexam.net]

CEREBELLAR ATAXIA  CLINICAL SYNOPSIS  Neurological  Miscellaneous  Labs  Treatment  Gene Map Locus: 19p13  Episodic ataxia  Cerebellar ataxia  Vertigo  Diplopia  Downbeat [slideshare.net]

Superior Semicircular Canal Dehiscence

Dix-Hallpike testing was normal; no downbeating nystagmus was seen. However, the air-bone gap was still present in the left ear. [canadianaudiologist.com]

On examination he was noted to have both a positional nystagmus (downbeating) as well as pulse-synchronous nystagmus (see video above). [dizziness-and-balance.com]

The absence of downbeating nystagmus in this patient may be attributed to destruction or injury to the ampulated end of the superior canal. Table 1. [canadianaudiologist.com]

Familial Progressive Vestibulocochlear Dysfunction

Downbeat nystagmus is also part of this syndrome, reflecting central vestibular dysfunction. [neuroophthalmology.ca]

There do seem to be a lot patients with both bilateral weakness and downbeating nystagmus. [tchain.com]

Downbeat nystagmus may be evident only on lateral gaze or in the supine position. [neuroophthalmology.ca]

X-Linked Spinocerebellar Ataxia Type 5

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [psychology.wikia.com]

Downbeat nystagmus improved, but there were no improvements in ataxia and balance. [30] Acetozolamide, a carbonic anhydrase inhibitor, showed clinical benefit in a group of [movementdisorders.org]

Autosomal Dominant Spastic Ataxia Type 1

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [psychology.wikia.com]

Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord 2009;24:1290–1295. 28. [e-jmd.org]

Episodic Ataxia

Examination showed slight downbeat nystagmus on lateral gaze, prominent positional downbeat nystagmus with vertigo, and mild truncal ataxia. [jnnp.bmj.com]

In the spell-free interval, patients present with central ocular motor dysfunction, mainly downbeat nystagmus. [ncbi.nlm.nih.gov]

[…] had induced GEN and downbeat nystagmus [ 10 ]. [e-jmd.org]

Autosomal Recessive Spinocerebellar Ataxia

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [psychology.wikia.com]

Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord. 2009; 24:1290–1295. [ CrossRef ] [ Google Scholar ] 28. [e-sciencecentral.org]

Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord 2009;24:1290–1295. 28. [e-jmd.org]

Platybasia

"Downbeating nystagmus and postural hypotension due to basilar invagination." J Med Assoc Thai 83 (12): 1530-4. Riew, K. D., A. S. Hilibrand, et al. (2001). [dizziness-and-balance.com]

[…] abducting eye with lateral gaze), downbeat nystagmus (fast component downward), hoarseness, dysarthria, and dysphagia. [merckmanuals.com]

Downbeating nystagmus and postural hypotension has been reported (Pratiparnawatr, Tiamkao et al. 2000) Our experience in our otoneurology practice has been that this is an [dizziness-and-balance.com]

Spinocerebellar Ataxia Type 20

nystagmus 0010545 Gait ataxia Inability to coordinate movements when walking 0002066 Gaze-evoked nystagmus 0000640 Hyperreflexia Increased reflexes 0001347 Isometric tremor [rarediseases.info.nih.gov]

Two of the six demonstrated downbeat nystagmus in the primary position on ophthalmoscopy, and one of these and one other displayed upwards gaze evoked nystagmus on upgaze. [jnnp.bmj.com]

Spinocerebellar Ataxia Type 26

The drug is fairly well tolerated and also can be used to treat downbeat nystagmus. [mdedge.com]

Spontaneous downbeat nystagmus was another consistent feature, and saccadic velocity was within normal limits. [35], [36] In a family initially classified as autosomal dominant [annalsofian.org]

Spastic Ataxia with Congenital Miosis

nystagmus, check for facial sensory loss). [ptpaces.wordpress.com]

[…] and other Ocular Oscillations Unilateral nystagmus Acquired monocular pendular nystagmus Monocular downbeat nystagmus Bilateral nystagmus Opsoclonus Ocular flutter Saccadic [pedseyes.org]

Interictal examination showed spontaneous downbeat and gaze-evoked nystagmus and mild dysarthria and truncal ataxia. [findzebra.com]

Vestibular Nystagmus

@article{Baloh1981DownbeatNA, title={Downbeat nystagmus: a type of central vestibular nystagmus.}, author={Robert W. Baloh and J. [semanticscholar.org]

The actual pathophysiology causing the downbeating nystagmus is not well understood at this point, but it is thought that the downbeating nystagmus results from an imbalance [fadavispt.mhmedical.com]

Downbeat Nystagmus QuickTime™ and a H.264 decompressor are needed to see this picture. Anti-GAD downbeat nystagmus 27. [slideshare.net]

X-Linked Congenital Nystagmus Type 5

Jacobs, PhDa,bRPOSE To investigate the effects of combinacquired downbeat nystagmus and horTHODS Patient 1 had downbeat nystagmus with aand diplopia. [vdocuments.site]

Upbeat jerk nystagmus. Upbeat nystagmus is less frequent than downbeat nystagmus. [neuroophthalmology.ca]

Keywords:: 3,4-diaminopyridine, acquired nystagmus, acquired pendular nystagmus, baclofen, downbeat nystagmus, gabapentin, infantile nystagmus, memantine, multiple sclerosis [tandfonline.com]

Convergence Nystagmus

Upbeat jerk nystagmus. Upbeat nystagmus is less frequent than downbeat nystagmus. [neuroophthalmology.ca]

The gait disorder in downbeat nystagmus syndrome. PLoS One. 2014. 9(8):e105463. [Medline]. [Full Text]. [medscape.com]

Downbeat Nystagmus, Gaze Evoked Nystagmus, Abnormal Saccades [collections.lib.utah.edu]

Cerebellar Ataxia - Neuropathy - Vestibular Areflexia Syndrome

Downbeat nystagmus, bilateral vestibular failure, and peripheral neuropathy, from idiopathic spinocerebellar degeneration. [neuroophthalmology.ca]

Does not include downbeating nystagmus because it is too common. [dizziness-and-balance.com]

On examination ataxia of gait, diminished knee and ankle reflexes, absence of plantar reflexes, fasciculations of thigh muscles, gaze-evoked downbeat nystagmus and abnormal [ncbi.nlm.nih.gov]