Downbeat Nystagmus: Causes & Reasons

Possible Causes for Downbeat Nystagmus

The phenotype is characterized by a purely cerebellar syndrome with a downbeat nystagmus occurring prior to the development of other features. [ncbi.nlm.nih.gov]

Two of the six demonstrated downbeat nystagmus in the primary position on ophthalmoscopy, and one of these and one other displayed upwards gaze evoked nystagmus on upgaze. [jnnp.bmj.com]

Arnold-Chiari Malformation

The Arnold-Chiari malfomation is typically associated with downbeat nystagmus. [ncbi.nlm.nih.gov]

Differential Diagnosis of downbeating nystagmus Other causes of constant downbeating nystagmus that should generally be considered are migraine, paraneoplastic cerebellar [dizziness-and-balance.com]

Eye movement recordings in two patients with Arnold-Chiari malfomation type 1 showed, in addition to downbeat and gaze evoked nystagmus, intermittent nystagmus of skew. [ncbi.nlm.nih.gov]

Brain Stem Disorder

nystagmus and oculomyoclonus (medullary involvement) See Clinical Presentation for more detail. [emedicine.medscape.com]

Sensory loss in the face (involvement of the trigeminal nucleus) Dysphagia and/or dysphonia from lower cranial nerve involvement (commonly IX and X) Long tract signs Ataxia Downbeating [emedicine.medscape.com]

Central Positional Vertigo

Downbeat nystagmus is the most common form of central vestibular nystagmus and results from defective vertical gaze holding that allows for a pathologic upward drift of the [aao.org]

The actual pathophysiology causing the downbeating nystagmus is not well understood at this point, but it is thought that the downbeating nystagmus results from an imbalance [mhmedical.com]

[…] reflex (VOR), or downbeat nystagmus. [ncbi.nlm.nih.gov]

Spinocerebellar Ataxia Type 6

We report two siblings with spinocerebellar ataxia type 6 (SCA 6), both showing downbeat nystagmus (DBN) as a predominant clinical feature. [ncbi.nlm.nih.gov]

Abstract To investigate the frequency of positioning nystagmus in degenerative ataxic disorders, we examined downbeat positioning nystagmus (DPN) in 25 patients with spinocerebellar [ncbi.nlm.nih.gov]

Examination showed slight downbeat nystagmus on lateral gaze, prominent positional downbeat nystagmus with vertigo, and mild truncal ataxia. [jnnp.bmj.com]

Hereditary Nystagmus

Upbeat jerk nystagmus. Upbeat nystagmus is less frequent than downbeat nystagmus. [neuroophthalmology.ca]

Downbeating nystagmus can be elicited by the head-shaking test. [tchain.com]

Consequently, the patient is best managed with treatments directed towards the underlying disorder.[6] Peripheral Vestibular Nystagmus Downbeat Nystagmus Downbeat nystagmus [webeye.ophth.uiowa.edu]

Autosomal Recessive Spinocerebellar Ataxia Type 17

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [psychology.wikia.com]

[…] neurologic reflexes ) Chromosome 16q SCA5 ( SPTBN2 ) 3rd - 4th decade (10-68) >25 years Pure cerebellar Chromosome 11 SCA6 [ 7 ] ( CACNA1A ) 5th - 6th decade (19-71) >25 years Downbeating [thefullwiki.org]

[…] neurologic reflexes ) Chromosome 16q SCA5 ( SPTBN2 ) 3rd - 4th decade (10-68) >25 years Pure cerebellar Chromosome 11 SCA6 [6] ( CACNA1A ) 5th - 6th decade (19-71) >25 years Downbeating [psychology.wikia.com]

Autosomal Recessive Spinocerebellar Ataxia 8

Clinically they have a coarse gaze-evoked nystagmus, downbeat nystagmus on lateral gaze, and poor visual suppression (Gomez et al, 1997). [tchain.com]

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [psychology.wikia.com]

According to Baloh and others (1997), EA2 is characterized by a progressive ataxia with interictal rebound nystagmus evoked by gaze, as well as downbeating nystagmus. [tchain.com]

Pineal Gland Neoplasm

ICD-10-CM Codes › C00-D49 Neoplasms › D10-D36 Benign neoplasms, except benign neuroendocrine tumors › D35- Benign neoplasm of other and unspecified endocrine glands › Benign neoplasm of pineal gland 2016 2017 2018 2019 Billable/Specific Code D35.4 is a billable/specific ICD-10-CM code that can be used to indicate a[…] [icd10data.com]

Phencyclidine Intoxication

Rhabdomyolysis can occur with phencyclidine hydrochloride (PCP) intoxication. However, to our knowledge acute renal failure with phencyclidine-induced rhabdomyolysis has not been reported previously. Therefore, we describe two patients with this condition. The modern treatment of phencyclidine intoxication, namely[…] [ncbi.nlm.nih.gov]

Pineal Gland Dysfunction

J. Axelrod Springer Science & Business Media, ٠١‏/١٢‏/٢٠١٣ - 604 من الصفحات The pineal gland has been a subject of interest and speculation for more than 2000 years. Greek anatomists were impressed by the ob servation that the pineal gland is an unpaired structure and they believed that it regulated the flow[…] [books.google.com]

Autosomal Recessive Spinocerebellar Ataxia 18

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [wikidoc.org]

Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord 2009;24:1290–1295. 28. [e-jmd.org]

[…] neurologic reflexes ) Chromosome 16q SCA5 ( SPTBN2 ) 3rd–4th decade (10–68) >25 years Pure cerebellar Chromosome 11 SCA6 [12] ( CACNA1A ) 5th–6th decade (19–71) >25 years Downbeating [en.wikipedia.org]

Spinocerebellar Ataxia Type 19

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [wikidoc.org]

Spontaneous downbeat nystagmus was another consistent feature, and saccadic velocity was within normal limits. [35], [36] In a family initially classified as autosomal dominant [annalsofian.org]

Tremor Head or Hand: SCA 8, 12, 15-16, 19, 27 Palatal: SCA 20 Normal lifespan: SCA 6, 11 Eye 60 Slow saccades Early/prominent: SCA 2, 7 Late: SCA 1, 3, 28 Very rarely: SCA 6 Nystagmus [neuromuscular.wustl.edu]

Autosomal Dominant Spastic Ataxia Type 1

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [psychology.wikia.com]

Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord 2009;24:1290–1295. 28. [e-jmd.org]

Infantile-Onset Autosomal Recessive Non-Progressive Cerebellar Ataxia

[…] by vision, downbeat nystagmus on lateral gaze, can seen in SCA 6. [explainmedicine.com]

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [en.wikipedia.org]

Identification of new genes Spinocerebellar ataxia autosomal recessive type 10: A new form of pure recessive ataxia accompanied by downbeat nystagmus and lower motor neuropathy [wjgnet.com]

Cerebellar Ataxia with Peripheral Neuropathy Type 2

nystagmus, cranial nerve palsies involving 9,10,12 or signs and symptoms of Syringomyelia Investigations include MRI scan for diagnosis and classification. [medexam.net]

CEREBELLAR ATAXIA  CLINICAL SYNOPSIS  Neurological  Miscellaneous  Labs  Treatment  Gene Map Locus: 19p13  Episodic ataxia  Cerebellar ataxia  Vertigo  Diplopia  Downbeat [slideshare.net]

Familial Progressive Vestibulocochlear Dysfunction

Downbeat nystagmus is also part of this syndrome, reflecting central vestibular dysfunction. [neuroophthalmology.ca]

There do seem to be a lot patients with both bilateral weakness and downbeating nystagmus. [tchain.com]

Downbeat nystagmus may be evident only on lateral gaze or in the supine position. [neuroophthalmology.ca]

X-Linked Spinocerebellar Ataxia Type 5

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [psychology.wikia.com]

Downbeat nystagmus improved, but there were no improvements in ataxia and balance. [30] Acetozolamide, a carbonic anhydrase inhibitor, showed clinical benefit in a group of [movementdisorders.org]

Spasmus Nutans

The gait disorder in downbeat nystagmus syndrome. PLoS One. 2014. 9(8):e105463. [Medline]. [Full Text]. [medscape.com]

Downbeating nystagmus can be elicited by the head-shaking test. [tchain.com]

Motor Imbalance <ul><li>Congential </li></ul><ul><li>Spasmus Nutans </li></ul><ul><li>Latent nystagmus </li></ul><ul><li>Ataxic nystagmus </li></ul><ul><li>Downbeat nystagmus [slideshare.net]

Episodic Ataxia

Examination showed slight downbeat nystagmus on lateral gaze, prominent positional downbeat nystagmus with vertigo, and mild truncal ataxia. [jnnp.bmj.com]

In the spell-free interval, patients present with central ocular motor dysfunction, mainly downbeat nystagmus. [ncbi.nlm.nih.gov]

[…] had induced GEN and downbeat nystagmus [ 10 ]. [e-jmd.org]

Autosomal Recessive Spinocerebellar Ataxia

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [psychology.wikia.com]

Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord. 2009; 24:1290–1295. [ CrossRef ] [ Google Scholar ] 28. [e-sciencecentral.org]

Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord 2009;24:1290–1295. 28. [e-jmd.org]

Syringomyelia - Syringobulbia

On lateral gaze, jerk nystagmus in the direction of the gaze and downbeat nystagmus were found. [jnnp.bmj.com]

Nystagmus (irregular eye movements; typically, so-called "downbeat nystagmus"). [disabled-world.com]

Superior Semicircular Canal Dehiscence

Dix-Hallpike testing was normal; no downbeating nystagmus was seen. However, the air-bone gap was still present in the left ear. [canadianaudiologist.com]

On examination he was noted to have both a positional nystagmus (downbeating) as well as pulse-synchronous nystagmus (see video above). [dizziness-and-balance.com]

The absence of downbeating nystagmus in this patient may be attributed to destruction or injury to the ampulated end of the superior canal. Table 1. [canadianaudiologist.com]

Cerebellar Ataxia

On examination ataxia of gait, diminished knee and ankle reflexes, absence of plantar reflexes, fasciculations of thigh muscles, gaze-evoked downbeat nystagmus and abnormal [ncbi.nlm.nih.gov]

Besides cerebellar ataxia, downbeat nystagmus is frequent. [jamanetwork.com]

nystagmus. [dx.doi.org]

Spinocerebellar Ataxia Type 26

The drug is fairly well tolerated and also can be used to treat downbeat nystagmus. [mdedge.com]

Spontaneous downbeat nystagmus was another consistent feature, and saccadic velocity was within normal limits. [35], [36] In a family initially classified as autosomal dominant [annalsofian.org]

Spastic Ataxia with Congenital Miosis

nystagmus, check for facial sensory loss). [ptpaces.wordpress.com]

[…] and other Ocular Oscillations Unilateral nystagmus Acquired monocular pendular nystagmus Monocular downbeat nystagmus Bilateral nystagmus Opsoclonus Ocular flutter Saccadic [pedseyes.org]

Interictal examination showed spontaneous downbeat and gaze-evoked nystagmus and mild dysarthria and truncal ataxia. [findzebra.com]

Spinocerebellar Ataxia Type 30

Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord 2009;24:1290–1295. 28. [e-jmd.org]

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [en.wikipedia.org]

Spinocerebellar Ataxia Type 20

nystagmus 0010545 Gait ataxia Inability to coordinate movements when walking 0002066 Gaze-evoked nystagmus 0000640 Hyperreflexia Increased reflexes 0001347 Isometric tremor [rarediseases.info.nih.gov]

Two of the six demonstrated downbeat nystagmus in the primary position on ophthalmoscopy, and one of these and one other displayed upwards gaze evoked nystagmus on upgaze. [jnnp.bmj.com]

Back Muscle Spasms

A 55-year-old woman developed progressive, painful, low back muscle spasms, vertical diplopia, downbeating nystagmus, and asymmetric appendicular ataxia. [ncbi.nlm.nih.gov]

nystagmus. [ncbi.nlm.nih.gov]

Downbeating nystagmus was present in primary gaze with an alternating skew deviation in lateral gaze. Serum and cerebrospinal fluid GAD antibodies were detected. [ncbi.nlm.nih.gov]

Subacute Cerebellar Degeneration

A case report and review of the literature. ( 6739288 ) Cavo M....Del Zotto E. 1984 29 Downbeat nystagmus with alcoholic cerebellar degeneration. ( 6497735 ) Zasorin N.L.. [malacards.org]

Most of the patients have diplopia, horizontal nystagmus, and half of them have rotatory or downbeating nystagmus [ 5-8 ]. [panafrican-med-journal.com]

Downbeat nystagmus is often a pathognomonic sign. Mild vibratory, proprioceptive sensory loss and pyramidal signs can be found. SCA-6 constitutes about 5-15% of ADCAs. [neuroweb.us]