Downbeat-nystagmus: Causes & Reasons

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Possible Causes for downbeat nystagmus

Spinocerebellar Ataxia Type 5

The phenotype is characterized by a purely cerebellar syndrome with a downbeat nystagmus occurring prior to the development of other features. [ncbi.nlm.nih.gov]

Two of the six demonstrated downbeat nystagmus in the primary position on ophthalmoscopy, and one of these and one other displayed upwards gaze evoked nystagmus on upgaze. [jnnp.bmj.com]

Arnold-Chiari Malformation

The Arnold-Chiari malfomation is typically associated with downbeat nystagmus. [ncbi.nlm.nih.gov]

Differential Diagnosis of downbeating nystagmus Other causes of constant downbeating nystagmus that should generally be considered are migraine, paraneoplastic cerebellar [dizziness-and-balance.com]

Eye movement recordings in two patients with Arnold-Chiari malfomation type 1 showed, in addition to downbeat and gaze evoked nystagmus, intermittent nystagmus of skew. [ncbi.nlm.nih.gov]

Nystagmus

Downbeating and rightbeating nystagmus Downbeating nystagmus means that the eyes drift upward, and "beat" or jump downward. Examples are shown above. [dizziness-and-balance.com]

Moreover, clinicians should be aware that downbeat nystagmus could be a manifestation of antiepileptic drug intoxication.Keywords: Nystagmus, pathologic, oxcarbazepine. [tjn.org.tr]

Confirmed physician diagnosis of LEMS, CMS or downbeat nystagmus. Completion of anti-cancer treatment at least 3 months (90 days) before treatment. [clinicaltrials.gov]

Central Positional Vertigo

Downbeat nystagmus is the most common form of central vestibular nystagmus and results from defective vertical gaze holding that allows for a pathologic upward drift of the [aao.org]

The actual pathophysiology causing the downbeating nystagmus is not well understood at this point, but it is thought that the downbeating nystagmus results from an imbalance [mhmedical.com]

[…] all dealt with elsewhere except for downbeating nystagmus on lateral gaze. [dizziness-and-balance.com]

Brain Stem Disorder

nystagmus and oculomyoclonus (medullary involvement) See Clinical Presentation for more detail. [emedicine.medscape.com]

Sensory loss in the face (involvement of the trigeminal nucleus) Dysphagia and/or dysphonia from lower cranial nerve involvement (commonly IX and X) Long tract signs Ataxia Downbeating [emedicine.medscape.com]

Spinocerebellar Ataxia Type 6

We report two siblings with spinocerebellar ataxia type 6 (SCA 6), both showing downbeat nystagmus (DBN) as a predominant clinical feature. [ncbi.nlm.nih.gov]

In analysis of CAG repeat length in patients with different types of nystagmus, CAG repeat length was the longest when both upbeat and downbeat nystagmus existed (P 0.01). [ncbi.nlm.nih.gov]

Abstract To investigate the frequency of positioning nystagmus in degenerative ataxic disorders, we examined downbeat positioning nystagmus (DPN) in 25 patients with spinocerebellar [ncbi.nlm.nih.gov]

Pineal Gland Neoplasm

ICD.Codes ICD-10-CM (2016) Chapter 2 Section C73-C75 Code C75.3 BILLABLE Billable Code Billable codes are sufficient justification for admission to an acute care hospital when used a principal diagnosis. ICD-10 from 2011 - 2016 C75.3 is a billable ICD code used to specify a diagnosis of malignant neoplasm of pineal gland.[…] [icd.codes]

Phencyclidine Intoxication

Abstract Phencyclidine (PCP) is a dissociative anesthetic whose abuse is a growing problem. Historically, its effects have been considered remarkably like those of the schizophrenic state, but in vitro and in vivo neuropharmacologic data are somewhat inconsistent with the dopaminergic hypothesis of schizophrenia. The[…] [ncbi.nlm.nih.gov]

Hereditary Nystagmus

Upbeat jerk nystagmus. Upbeat nystagmus is less frequent than downbeat nystagmus. [neuroophthalmology.ca]

Downbeating nystagmus can be elicited by the head-shaking test. [tchain.com]

Downbeat nystagmus is associated with cervicocranial abnormalities, such as Arnold-Chiari malformation or spinal cerebellar degeneration. Monocular nystagmus. [aao.org]

Pineal Gland Dysfunction

Kjell Fuxe, Jan-Åke Gustafsson, Lennart Wetterberg Elsevier, ٢٢‏/١٠‏/٢٠١٣ - 424 من الصفحات Steroid Hormone Regulation of the Brain focuses on the advancement of knowledge of the properties of brain steroid receptors and steroid target nerve cells, including the actions of gonadal steroids, adrenocortical[…] [books.google.com]

Hyperventilation

No change, minor downbeating nystagmus, or accentuation of already present nystagmus, is counted as a negative HVIN. [dizziness-and-balance.com]

What hyperventilation induced nystagmus (HVIN) looks like. In normal persons, HVIN is a low amplitude downbeating nystagmus. An example is shown below. [dizziness-and-balance.com]

Here are his observations: Normal persons - -often have low-amplitude downbeating nystagmus after vigorous HVT. [dizziness-and-balance.com]

Autosomal Recessive Spinocerebellar Ataxia Type 17

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [psychology.wikia.com]

[…] neurologic reflexes ) Chromosome 16q SCA5 ( SPTBN2 ) 3rd - 4th decade (10-68) 25 years Pure cerebellar Chromosome 11 SCA6 [ 7 ] ( CACNA1A ) 5th - 6th decade (19-71) 25 years Downbeating [thefullwiki.org]

[…] neurologic reflexes ) Chromosome 16q SCA5 ( SPTBN2 ) 3rd - 4th decade (10-68) 25 years Pure cerebellar Chromosome 11 SCA6 [6] ( CACNA1A ) 5th - 6th decade (19-71) 25 years Downbeating [psychology.wikia.com]

Occult Malignancy

Primary position downbeating nystagmus is an uncommon manifestation of an occult malignancy. [ncbi.nlm.nih.gov]

We report a case of primary position downbeating nystagmus due to an occult breast carcinoma in a 57-year-old woman with progressive oscillopsia and truncal ataxia. [ncbi.nlm.nih.gov]

nystagmus. [ncbi.nlm.nih.gov]

Autosomal Recessive Spinocerebellar Ataxia 8

Clinically they have a coarse gaze-evoked nystagmus, downbeat nystagmus on lateral gaze, and poor visual suppression (Gomez et al, 1997). [tchain.com]

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [psychology.wikia.com]

According to Baloh and others (1997), EA2 is characterized by a progressive ataxia with interictal rebound nystagmus evoked by gaze, as well as downbeating nystagmus. [tchain.com]

Episodic Ataxia

In the spell-free interval, patients present with central ocular motor dysfunction, mainly downbeat nystagmus. [ncbi.nlm.nih.gov]

Examination showed slight downbeat nystagmus on lateral gaze, prominent positional downbeat nystagmus with vertigo, and mild truncal ataxia. [jnnp.bmj.com]

[…] had induced GEN and downbeat nystagmus [ 10 ]. [e-jmd.org]

Benign Paroxysmal Positional Vertigo

KEYWORDS: anterior semicircular canal; benign paroxysmal positional vertigo; canalolithiasis; cupulolithiasis; downbeat nystagmus; lateral semicircular canal; positional nystagmus [ncbi.nlm.nih.gov]

Abbreviations 3,4-DAP, 3,4-diaminopyridine; 4-AP, 4-aminopyridine; DBN, downbeat nystagmus; DVA, dynamic visual acuity; HIT, head impulse test; OVAR, off-vertical axis rotation [doi.org]

Examples of such causal therapy include aminopyridines for downbeat nystagmus and episodic ataxia type 2; carbamazepine for vestibular paroxysmia, paroxsymal dysarthria and [doi.org]

Cerebellar Ataxia

On examination ataxia of gait, diminished knee and ankle reflexes, absence of plantar reflexes, fasciculations of thigh muscles, gaze-evoked downbeat nystagmus and abnormal [ncbi.nlm.nih.gov]

nystagmus. [doi.org]

Google Scholar Crossref Medline ISI Baloh, R., Spooner, J. ( 1981 ) Downbeat nystagmus: a type of central vestibular nystagmus. Neurology 31: 304 – 310. [doi.org]

Arnold-Chiari Malformation Type 1

On lateral gaze, jerk nystagmus in the direction of the gaze and downbeat nystagmus were found. [jnnp.bmj.com]

Nystagmus (irregular eye movements; typically, so-called "downbeat nystagmus"). [disabled-world.com]

Superior Semicircular Canal Dehiscence

counterclockwise) downbeat nystagmus, during which the patient reported vertigo. [canadianaudiologist.com]

On examination he was noted to have both a positional nystagmus (downbeating) as well as pulse-synchronous nystagmus (see video above). [dizziness-and-balance.com]

Dix-Hallpike testing was normal; no downbeating nystagmus was seen. However, the air-bone gap was still present in the left ear. [canadianaudiologist.com]

Malnutrition

Downbeat nystagmus Downbeat nystagmus is defined as nystagmus with the fast phase beating in a downward direction. [4] The nystagmus usually is of maximal intensity when the [emedicine.medscape.com]

This nystagmus can be upbeat, downbeat, horizontal, or mixed and is more common than optokinetic nystagmus. [ncbi.nlm.nih.gov]

Autoantibodies to glutamic acid decarboxylase in downbeat nystagmus. [eyewiki.aao.org]

Back Muscle Spasms

A 55-year-old woman developed progressive, painful, low back muscle spasms, vertical diplopia, downbeating nystagmus, and asymmetric appendicular ataxia. [ncbi.nlm.nih.gov]

nystagmus. [ncbi.nlm.nih.gov]

Downbeating nystagmus was present in primary gaze with an alternating skew deviation in lateral gaze. Serum and cerebrospinal fluid GAD antibodies were detected. [ncbi.nlm.nih.gov]

Platybasia

"Downbeating nystagmus and postural hypotension due to basilar invagination." J Med Assoc Thai 83 (12): 1530-4. Riew, K. D., A. S. Hilibrand, et al. (2001). [dizziness-and-balance.com]

[…] abducting eye with lateral gaze), downbeat nystagmus (fast component downward), hoarseness, dysarthria, and dysphagia. [merckmanuals.com]

Downbeating nystagmus and postural hypotension has been reported (Pratiparnawatr, Tiamkao et al. 2000) Our experience in our otoneurology practice has been that this is an [dizziness-and-balance.com]

Autosomal Recessive Spinocerebellar Ataxia 18

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [wikidoc.org]

Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord 2009;24:1290–1295. 28. [e-jmd.org]

[…] neurologic reflexes ) Chromosome 16q SCA5 ( SPTBN2 ) 3rd–4th decade (10–68) 25 years Pure cerebellar Chromosome 11 SCA6 [12] ( CACNA1A ) 5th–6th decade (19–71) 25 years Downbeating [en.wikipedia.org]

Spinocerebellar Ataxia Type 19

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [wikidoc.org]

Spontaneous downbeat nystagmus was another consistent feature, and saccadic velocity was within normal limits. [35], [36] In a family initially classified as autosomal dominant [annalsofian.org]

Two of the six demonstrated downbeat nystagmus in the primary position on ophthalmoscopy, and one of these and one other displayed upwards gaze evoked nystagmus on upgaze. [jnnp.bmj.com]

Familial Progressive Vestibulocochlear Dysfunction

Downbeat nystagmus is also part of this syndrome, reflecting central vestibular dysfunction. [neuroophthalmology.ca]

There do seem to be a lot patients with both bilateral weakness and downbeating nystagmus. [tchain.com]

Downbeat nystagmus may be evident only on lateral gaze or in the supine position. [neuroophthalmology.ca]

Infantile-Onset Autosomal Recessive Nonprogressive Cerebellar Ataxia

[…] by vision, downbeat nystagmus on lateral gaze, can seen in SCA 6. [explainmedicine.com]

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [en.wikipedia.org]

Identification of new genes Spinocerebellar ataxia autosomal recessive type 10: A new form of pure recessive ataxia accompanied by downbeat nystagmus and lower motor neuropathy [wjgnet.com]

Psychogenic Hyperventilation

No change, minor downbeating nystagmus, or accentuation of already present nystagmus, is counted as a negative HVIN. [dizziness-and-balance.com]

What hyperventilation induced nystagmus (HVIN) looks like. In normal persons, HVIN is a low amplitude downbeating nystagmus. An example is shown below. [dizziness-and-balance.com]

Here are his observations: Normal persons - -often have low-amplitude downbeating nystagmus after vigorous HVT. [dizziness-and-balance.com]

Autosomal Dominant Spastic Ataxia Type 1

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [psychology.wikia.com]

Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord 2009;24:1290–1295. 28. [e-jmd.org]

Autosomal Recessive Spinocerebellar Ataxia

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [psychology.wikia.com]

Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord. 2009; 24:1290–1295. [ CrossRef ] [ Google Scholar ] 28. [e-sciencecentral.org]

Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord 2009;24:1290–1295. 28. [e-jmd.org]

Spinous Process Fracture

The most consistent clinical feature was downbeat nystagmus; 3 affected patients had downbeat nystagmus as an isolated feature. [flybase.org]

nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old. [en.wikipedia.org]

Positional vertigo and macroscopic downbeat positioning nystagmus in spinocerebellar ataxia type 6 (SCA6). [frontiersin.org]