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29 Possible Causes for Downbeat Nystagmus, Muscle Twitch, Onset of Dysarthria in Third Decade of Life

  • Spinocerebellar Ataxia Type 5

    The onset of symptoms is usually in the third or fourth decade of life; however, more subtle clinical manifestations can start in early childhood.[ncbi.nlm.nih.gov] The phenotype is characterized by a purely cerebellar syndrome with a downbeat nystagmus occurring prior to the development of other features.[ncbi.nlm.nih.gov] Those with SCA will also often experience numbness, tingling or pain in their limbs, uncontrolled muscle tensing, muscle wasting and muscle twitching.[indycann.org]

  • Episodic Ataxia

    This abnormality can cause muscle cramping, stiffness, and continuous, fine muscle twitching that appears as rippling under the skin.[ghr.nlm.nih.gov] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.com] In the spell-free interval, patients present with central ocular motor dysfunction, mainly downbeat nystagmus.[ncbi.nlm.nih.gov]

  • Autosomal Recessive Spinocerebellar Ataxia Type 17

    […] of muscles or parts of muscles, without any rhythm or pattern, occurring in various brain disorders) 19q SCA16 39 yrs (20-66) 1-40 years Head and hand tremor 8q SCA17 ( TBP[psychology.wikia.com] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] Tremor, sensory loss, twitches of facial muscles, and slowness and stiffness similar to that seen in Parkinson’s disease have been observed in SCA-14.[ataxiacenter.umn.edu]

  • Autosomal Recessive Spinocerebellar Ataxia 8

    […] of muscles or parts of muscles, without any rhythm or pattern, occurring in various brain disorders) 19q SCA16 39 yrs (20-66) 1-40 years Head and hand tremor 8q SCA17 ( TBP[psychology.wikia.com] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] Clinically they have a coarse gaze-evoked nystagmus, downbeat nystagmus on lateral gaze, and poor visual suppression (Gomez et al, 1997).[tchain.com]

  • Autosomal Dominant Sensory Ataxia

    The episodes are triggered by stress, being startled, or sudden movement and are often associated with muscle twitching.[disabled-world.com] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] nystagmus.[learningneurology.com]

  • Spinocerebellar Ataxia Type 1

    (atrophy); and muscle twitches (fasciculations).[ghr.nlm.nih.gov] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.com] Logistic regression analysis controlling for disease duration revealed that spontaneous and positional downbeat nystagmus and perverted head‐shaking nystagmus were strong[doi.org]

  • Cerebellar Ataxia with Peripheral Neuropathy Type 2

    The episodes are triggered by stress, being startled or sudden movement, and often are associated with muscle twitching.[mayoclinic.org] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] nystagmus, cranial nerve palsies involving 9,10,12 or signs and symptoms of Syringomyelia Investigations include MRI scan for diagnosis and classification.[medexam.net]

  • Autosomal Dominant Spastic Ataxia Type 1

    (atrophy); and muscle twitches (fasciculations).[ghr.nlm.nih.gov] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old.[psychology.wikia.com]

  • Autosomal Recessive Spinocerebellar Ataxia

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old.[psychology.wikia.com] Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord. 2009; 24:1290–1295. [ CrossRef ] [ Google Scholar ] 28.[e-sciencecentral.org]

  • Spinocerebellar Ataxia Type 19

    […] of muscles or parts of muscles, without any rhythm or pattern, occurring in various brain disorders) 19q SCA16 39 yrs (20-66) 1-40 years Head and hand tremor 8q SCA17 ( TBP[wikidoc.org] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] Tremor, sensory loss, twitches of facial muscles, and slowness and stiffness similar to that seen in Parkinson’s disease have been observed in SCA-14.[ataxiacenter.umn.edu]

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