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32 Possible Causes for Downbeat Nystagmus, Onset of Dysarthria in Third Decade of Life

  • Spinocerebellar Ataxia Type 5

    The onset of symptoms is usually in the third or fourth decade of life; however, more subtle clinical manifestations can start in early childhood.[ncbi.nlm.nih.gov] The phenotype is characterized by a purely cerebellar syndrome with a downbeat nystagmus occurring prior to the development of other features.[ncbi.nlm.nih.gov] Two of the six demonstrated downbeat nystagmus in the primary position on ophthalmoscopy, and one of these and one other displayed upwards gaze evoked nystagmus on upgaze.[jnnp.bmj.com]

  • Spinocerebellar Ataxia Type 6

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.com] We report two siblings with spinocerebellar ataxia type 6 (SCA 6), both showing downbeat nystagmus (DBN) as a predominant clinical feature.[ncbi.nlm.nih.gov] In analysis of CAG repeat length in patients with different types of nystagmus, CAG repeat length was the longest when both upbeat and downbeat nystagmus existed (P 0.01).[ncbi.nlm.nih.gov]

  • Autosomal Recessive Spinocerebellar Ataxia Type 17

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old.[psychology.wikia.com] […] neurologic reflexes ) Chromosome 16q SCA5 ( SPTBN2 ) 3rd - 4th decade (10-68) 25 years Pure cerebellar Chromosome 11 SCA6 [ 7 ] ( CACNA1A ) 5th - 6th decade (19-71) 25 years Downbeating[thefullwiki.org]

  • Autosomal Recessive Spinocerebellar Ataxia 8

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] Clinically they have a coarse gaze-evoked nystagmus, downbeat nystagmus on lateral gaze, and poor visual suppression (Gomez et al, 1997).[tchain.com] nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old.[psychology.wikia.com]

  • Episodic Ataxia

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.com] In the spell-free interval, patients present with central ocular motor dysfunction, mainly downbeat nystagmus.[ncbi.nlm.nih.gov] Examination showed slight downbeat nystagmus on lateral gaze, prominent positional downbeat nystagmus with vertigo, and mild truncal ataxia.[jnnp.bmj.com]

  • Infantile-Onset Autosomal Recessive Nonprogressive Cerebellar Ataxia

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] […] by vision, downbeat nystagmus on lateral gaze, can seen in SCA 6.[explainmedicine.com] nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old.[en.wikipedia.org]

  • Spinocerebellar Ataxia Type 19

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old.[wikidoc.org] Spontaneous downbeat nystagmus was another consistent feature, and saccadic velocity was within normal limits. [35], [36] In a family initially classified as autosomal dominant[annalsofian.org]

  • Autosomal Dominant Spastic Ataxia Type 1

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old.[psychology.wikia.com] Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord 2009;24:1290–1295. 28.[e-jmd.org]

  • Autosomal Recessive Spinocerebellar Ataxia

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old.[psychology.wikia.com] Perverted head-shaking and positional downbeat nystagmus in patients with multiple system atrophy. Mov Disord. 2009; 24:1290–1295. [ CrossRef ] [ Google Scholar ] 28.[e-sciencecentral.org]

  • X-Linked Spinocerebellar Ataxia Type 5

    […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com] nystagmus, positional vertigo Symptoms can appear for the first time as late as 65 years old.[psychology.wikia.com] […] neurologic reflexes ) Chromosome 16q SCA5 ( SPTBN2 ) 3rd–4th decade (10–68) 25 years Pure cerebellar Chromosome 11 SCA6 [12] ( CACNA1A ) 5th–6th decade (19–71) 25 years Downbeating[en.wikipedia.org]

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