Downturned Corners of the Mouth: Causes & Reasons

Possible Causes for Downturned Corners of the Mouth

corners of the mouth, short stature, and marked susceptibility to malignant hyperthermia. [ncbi.nlm.nih.gov]

corners of mouth Downturned corners of the mouth Downturned mouth [ more ] 0002714 Feeding difficulties Feeding problems Poor feeding [ more ] 0011968 Flexion contracture [rarediseases.info.nih.gov]

Symptoms in NAM include congenital muscle weakness and contractures, progressive scoliosis, early ventilatory failure, a peculiar facial gestalt with mild ptosis and downturned [ncbi.nlm.nih.gov]

Russell-Silver Syndrome

Consistent newborn features include small triangular facies, narrow chin, smallish jaw, downturned corners of the mouth, limb asymmetry, and fifth finger clinodactyly. [radiologykey.com]

corners of the mouth Fifth finger clinodactyly May have coffee coloured birthmark *Please be aware, not all of the characteristics may be present* Other information about [littlepeopleuk.org]

corners of mouth Downturned corners of the mouth Downturned mouth [ more ] 0002714 Failure to thrive in infancy Faltering weight in infancy Weight faltering in infancy [ [rarediseases.info.nih.gov]

Wolf-Hirschhorn Syndrome

Downturned corners of the mouth. Small lower jaw. Orofacial/odontological symptoms Characteristic facial features are associated with the diagnosis. [mun-h-center.se]

Microcephaly, hypertelorism, prominent glabella, high arched eyebrows, broad nose, short philtrum, downturned corners of the mouth, dysplastic ears with pits/tags. [genetics4medics.com]

corners of the mouth (32.3%). [mdpi.com]

Warburg Micro Syndrome 3

corners of mouth ; Flexion contracture ; Hypertrichosis ; Hypoplasia of the corpus callosum ; Intellectual disability, profound ; Kyphoscoliosis ; Low anterior hairline ; [mousephenotype.org]

corners of mouth Low anterior hairline Narrow palate Short nose Abnormality of limbs Ankle clonus Clinodactyly of the 5th finger Abnormality of the breast Wide intermamillary [ncbi.nlm.nih.gov]

Downturned corners of mouth MedGen UID: 356471 •Concept ID: C1866195 • Anatomical Abnormality A morphological abnormality of the mouth in which the angle of the mouth is downturned [ncbi.nlm.nih.gov]

Thakker-Donnai Syndrome

corners of the mouth) as well as vertebral (occult spina bifida, hemivertebrae), brain (ventricular dilatation, agenesis of corpus callosum), cardiac (tetralogy of Fallot [orpha.net]

[…] dysmorphism (including long, downward slanting palpebral fissures, hypertelorism, posteriorly rotated ears, broad nasal bridge, short nose with a bulbous tip and anteverted nares, downturned [orpha.net]

Recombinant Chromosome 8 Syndrome

corners of mouth Downturned corners of the mouth Downturned mouth [ more ] 0002714 Global developmental delay 0001263 Hypertelorism Wide-set eyes Widely spaced eyes [ more [rarediseases.info.nih.gov]

corners of mouth 31 hallmark (90%) HP:0002714 11 redundant skin 31 hallmark (90%) HP:0001582 12 deep plantar creases 31 hallmark (90%) HP:0001869 13 spasticity 31 frequent [malacards.org]

Digito-Reno-Cerebral Syndrome

Additional features include coarse facies, a large nose with wide nasal bridge, bulbous tip and anteverted nares, a long prominent philtrum and downturned corners of the mouth [uniprot.org]

corners of the mouth. [onlinelibrary.wiley.com]

[…] syndrome is associated with characteristic, coarse facial features with large nose with wide nasal bridge, bulbous tip and anteverted nares, a long prominent philtrum and downturned [onlinelibrary.wiley.com]

X-Linked Syndromic Intellectual Disability Type Nascimento

corners of mouth Enophthalmos Low posterior hairline Macrocephaly Prominent supraorbital ridges Synophrys Thin vermilion border Upslanted palpebral fissure ... ... [familydiagnosis.com]

corners of mouth ; Dry skin ; Echolalia ; Hirsutism ; Hypointensity of cerebral white matter on MRI ; Increased body weight ; Intellectual disability ; Low posterior hairline [mousephenotype.org]

corners of mouth, Short foot, Hypointensity of cerebral white matter on MRI, Hirsutism, Depressed nasal bridge Skip the waiting lines. [fdna.health]

Carnevale Krajewska Fischetto Syndrome

corners of mouth Highly arched eyebrow Hypertelorism Prominence of the premaxilla ... ... [familydiagnosis.com]

corners of mouth Epicanthus inversus Highly arched eyebrow Prominent nasal bridge Wide nasal bridge Abnormality of limbs Limited elbow movement Abnormality of the eye Hypertelorism [ncbi.nlm.nih.gov]

The palate is high-arched and narrow, the philtrum smooth, and the corners of the mouth are downturned. [accesspediatrics.mhmedical.com]

Hyperphosphatasia with Mental Retardation

Midface hypoplasia, prognathism, hypertelorism, long palpebral fissures, arched eyebrows, broad nasal bridge and tip, cleft palate (rare), short philtrum, downturned corners [iofbonehealth.org]

She had long palpebral ﬁssures, a prominent nasal bridge, simple cupped ears with thickened helices, and a tented upper lip with downturned corners of the mouth (Fig. 1A). [dev.docslide.net]

[…] of the mouth, tented mouth, ventral septal defect (rare), feeding problems necessitating tube feeding (in some patients), anteriorly displaced anus (in some patients), anovestibular [iofbonehealth.org]

Deficiency of Glycerol Kinase

corners of mouth Downturned corners of the mouth Downturned mouth [ more ] 0002714 Episodic vomiting 0002572 Frontal bossing 0002007 Growth delay Delayed growth Growth deficiency [rarediseases.info.nih.gov]

[…] of people have these symptoms Abnormal facial shape Unusual facial appearance 0001999 Percent of people who have these symptoms is not available through HPO Coma 0001259 Downturned [rarediseases.info.nih.gov]

Partial Monosomy 18q

corners of mouth and delayed eruption of teeth. [1], [6] Hermesch et al. (2000) observed quite similar prevalence of dental caries in genetically unaffected siblings and [jisppd.com]

[…] and D18S1149 on 18q, a distance of approximately 4 Mb. [5] Orofacial findings observed in this syndrome can be long philtrum, microstomy, malocclusion, dental hypoplasia, downturned [jisppd.com]

Stevenson Carey Syndrome

[…] and Downturned corners of mouth that can help you solving undiagnosed cases. [mendelian.co]

Diseases related with Flexion contracture and Downturned corners of mouth In the following list you will find some of the most common rare diseases related to Flexion contracture [mendelian.co]

Patients also present intrauterine growth retardation, facial dysmorphism (flat facial profile, low-set ears, shallow orbits, short and upturned nose, downturned corners of [mendelian.co]

Chromosome 17p13.1 Deletion Syndrome

corners of mouth Biliary tract abnormality Diastasis recti Communicating hydrocephalus Anterior hypopituitarism Hypoplastic labia majora Stenosis of the external auditory [mendelian.co]

Wide intermamillary distance Decreased fetal movement Rieger anomaly Hypoplasia of the uterus Clitoral hypoplasia Abnormality of the pulmonary artery Limited elbow movement Downturned [mendelian.co]

Turner Syndrome

Turner syndrome, first described in 1938 by Henry Turner, is as loss or abnormality of the second X chromosome in at least one cell line in a phenotypic female. At birth, girls with Turner syndrome may have swollen hands and feet because of lymphedema. The blend of dysplastic or hypoplastic nails and lymphedema[…] [symptoma.com]

Malignant Hyperthermia - Arthrogryposis - Torticollis

corners of mouth Downturned corners of the mouth Downturned mouth [ more ] 0002714 Hypotelorism Abnormally close eyes Closely spaced eyes [ more ] 0000601 Long palm 0011302 [rarediseases.info.nih.gov]

59 32 frequent (33%) Frequent (79-30%) HP:0000160 26 conductive hearing impairment 59 32 frequent (33%) Frequent (79-30%) HP:0000405 27 downturned corners of mouth 59 32 [malacards.org]

corners of mouth Abnormality of the foot Generalized hypotonia due to defect at the neuromuscular junction Apneic episodes precipitated by illness, fatigue, stress Diarrhea [mendelian.co]

Jacobsen Syndrome

These include: wide-set eyes with droopy eyelids small and low-set ears a broad nasal bridge downturned corners of the mouth a small lower jaw a thin upper lip skin folds [healthline.com]

a broad nasal bridge, downturned corners of the mouth, a thin upper lip, and a small lower jaw. [ghr.nlm.nih.gov]

These include small and low-set ears, widely set eyes ( hypertelorism ) with droopy eyelids ( ptosis ), skin folds covering the inner corner of the eyes ( epicanthal folds [ghr.nlm.nih.gov]

Chromosome 18p Deletion Syndrome

The proband is a 15-year-old male who has had phenotypes manifested mainly by brachycephaly, broad faces, ptosis, downturned corners of the mouth, tooth abnormalities, broad [academic.oup.com]

0000175 Downturned corners of mouth Downturned corners of the mouth Downturned mouth [ more ] 0002714 Enlarged thorax Wide rib cage 0100625 Epicanthus Eye folds Prominent [rarediseases.info.nih.gov]

The phenotypic manifestations were the following: brachycephaly, broad face, ptosis, downturned corners of the mouth, tooth abnormalities, broad neck with a low posterior [academic.oup.com]

Disorder of Sex Development - Intellectual Disability Syndrome

Showing of 31 | 80%-99% of people have these symptoms Deeply set eye Deep set eye Deep-set eyes Sunken eye [ more ] 0000490 Downturned corners of mouth Downturned corners [rarediseases.info.nih.gov]

corners of mouth 60 33 hallmark (90%) Very frequent (99-80%) HP:0002714 16 hypoplasia of penis 60 33 hallmark (90%) Very frequent (99-80%) HP:0008736 17 spina bifida occulta [malacards.org]

[…] of the mouth Downturned mouth [ more ] 0002714 Genu valgum Knock knees 0002857 Hypogonadism Decreased activity of gonads 0000135 Hypoplasia of penis Underdeveloped penis 0008736 [rarediseases.info.nih.gov]

Cornelia De Lange Syndrome

corners of the mouth. [onlinelibrary.wiley.com]

Clinical description Distinctive facial features include: well-defined curved and confluent eyebrows, long eyelashes, anteverted nares, micrognathia, and downturned corners [orpha.net]

corners of the mouth, producing a crescent shaped mouth. [aadmd.org]

Congenital Aural Atresia

corners of mouth Dysplastic patella Exostosis of the external auditory canal Fused cervical vertebrae High palate Hip dislocation Hypoplastic nipples Hypospadias Inguinal [familydiagnosis.com]

[HPO:curators] Show HP:0002714 Downturned corners of mouth "A morphological `abnormality of the mouth` (HP:0000153) in which the `angle of the mouth` (FMA:77269) is downturned [manteia.igbmc.fr]

corners of mouth Epicanthus Facial asymmetry High palate Hypertelorism Hypoplastic mandible condyle Long face Long philtrum Low posterior hairline Microcephaly Narrow mouth [familydiagnosis.com]

Monosomy 21q

And Oral Structures Downturned Corners Of The Mouth Cleft Lip/Or Palate Highly Arched Palate Abdomen Inguinal Hernia Hand And Foot Talipes Equinovarus, Camptodactyly, Long [neo-genetics.com]

corners to the mouth, body asymme-try, and fifth-finger clinodactyly. [documents.tips]

Features: Head And Neck Prominent Glabella, Microcephaly Micrognathia, And Maxillary Prognathism Ears Large Low-Set Ears Eyes Microphthalmia And Downslanting Palpebral Fissures Mouth [neo-genetics.com]

Autosomal-Recessive Non-Lethal Multiple Pterygium Syndrome

corners of the mouth, long philtrum, high-arched palate, digital and intercrural webbings, and aplasia of the labia majora were indicative of MPS (Escobar syndrome). [degruyter.com]

[from OMIM] Show allHide all Abnormality of head or neck Cleft palate Dental malocclusion Downslanted palpebral fissures Downturned corners of mouth Epicanthal fold High palate [ncbi.nlm.nih.gov]

corners of mouth Downturned corners of the mouth Downturned mouth [ more ] 0002714 Dysplastic patella 0006446 Exostosis of the external auditory canal 0004459 Fused cervical [rarediseases.info.nih.gov]

Trisomy 12p

corners of mouth Downturned corners of the mouth Downturned mouth [ more ] 0002714 Epicanthus Eye folds Prominent eye folds [ more ] 0000286 Everted lower lip vermilion Drooping [rarediseases.info.nih.gov]

[…] with downturned corners, thin upper lip and distinct cupid bow (“Pallister lip”), micrognathia, and low-set dysplastic ears [21,22,23,24,25,26,27,28,29,30]. [mdpi.com]

[…] symptoms Abnormality of chromosome segregation 0002916 Abnormality of the antihelix 0009738 Clinodactyly of the 5th finger Permanent curving of the pinkie finger 0004209 Downturned [rarediseases.info.nih.gov]

SHORT Syndrome

corners of the mouth, micrognathia and prominent (but not typically low-set or posteriorly located) ears. [orpha.net]

corners of mouth Downturned corners of the mouth Downturned mouth [ more ] 0002714 Enlarged epiphyses Large end part of bone 0010580 Frontal bossing 0002007 Hyperglycemia [rarediseases.info.nih.gov]

[…] characteristic facial gestalt, often described as progeroid, with triangular face shape, prominent forehead, ocular depression, hypoplastic alae nasi, low-hanging columella, downturned [orpha.net]

14q32 Duplication Syndrome

The face showed slightly coarse features with widely spaced teeth, broad mouth, downturned corners of the mouth, broad nasal root, and deep nasal bridge. [proquest.com]

She showed a dysmorphic face, including frontal bossing, widely spaced teeth, broad upper alveolar ridges, broad mouth, downturned corners of the mouth, broad nasal root, [proquest.com]

(Lower panel) A dysmorphic face characterized by frontal bossing, widely spaced teeth, broad upper alveolar ridges, broad mouth, downturned corners of the mouth, broad nasal [proquest.com]

Pontocerebellar Hypoplasia Type 1A

[from OMIM] Show allHide all Abnormality of head or neck Depressed nasal bridge Downturned corners of mouth Full cheeks High palate High, narrow palate Long palpebral fissure [ncbi.nlm.nih.gov]

Pontocerebellar Hypoplasia Type 1D

[from OMIM] Show allHide all Abnormality of head or neck Depressed nasal bridge Downturned corners of mouth Full cheeks High palate High, narrow palate Long palpebral fissure [ncbi.nlm.nih.gov]

Monosomy 4p

[…] with downturned corners, and micrognathia), and a seizure disorder (Battaglia et al., 2008). [ncbi.nlm.nih.gov]

corners of mouth Epicanthal fold High forehead Highly arched eyebrow Low posterior hairline Oral cleft Partial congenital absence of teeth Prominent glabella Short philtrum [ncbi.nlm.nih.gov]

[…] warrior helmet' appearance of the nose, high forehead, prominent glabella, hypertelorism, high-arched eyebrows, protruding eyes, epicanthal folds, short philtrum, distinct mouth [ncbi.nlm.nih.gov]

MEHMO Syndrome

corners of mouth Downturned corners of the mouth Downturned mouth [ more ] 0002714 Full cheeks Apple cheeks Big cheeks Increased size of cheeks Large cheeks [ more ] 0000293 [rarediseases.info.nih.gov]

0000340 Thick vermilion border Full lips Increased volume of lip Plump lips Prominent lips Thick lips [ more ] 0012471 30%-79% of people have these symptoms Agitation 0000713 Downturned [rarediseases.info.nih.gov]