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454 Possible Causes for Drug Hypersensitivity, T Cell Activation Increased

  • Common Cold

    cell proliferation, 15 shifts in T helper cell cytokine responses, 16, , 17 decreases in natural killer (NK) cell cytotoxicity, 18, , 19 and increased activation of proinflammatory[doi.org] Herrero, Nitroparacetamol (NCX-701) and Pain: First in a Series of Novel Analgesics, CNS Drug Reviews, 13, 3, (279), (2007).[doi.org] cell proliferation, 15 shifts in T helper cell cytokine responses, 16, 17 decreases in natural killer (NK) cell cytotoxicity, 18, 19 and increased activation of proinflammatory[ncbi.nlm.nih.gov]

  • Hypersensitivity

    However, increased activation of CD4 T-cell and CD8 T-cells was only observed following four days of DDAB exposure.[ncbi.nlm.nih.gov] ) and non-immediate drug hypersensitivity reactions (NIDHRs).[ncbi.nlm.nih.gov] Drug-induced hypersensitivity belongs to those type B reactions.[frontiersin.org]

  • Food Allergy

    Memory T cells are increased in frequency and have distinct activation requirements and cell-surface proteins that distinguish them from armed effector T cells 10-25.[ncbi.nlm.nih.gov] hypersensitivity Asthma Allergies Board Certifications Allergy & Immunology, American Board of Allergy and Immunology Locations Boston: Pediatric Allergy & Immunology Boston[massgeneral.org] Several other drugs have a food component, resulting in contraindications and warnings in product labeling.[ncbi.nlm.nih.gov]

  • Contact Dermatitis

    Investigations of allergic contact dermatitis suggest that certain allergens may also activate particular T cell signatures such as TH 2-dominant responses to fragrance and[ncbi.nlm.nih.gov] A relationship between systemic delayed drug hypersensitivity and ACD, as observed in one case, suggests that patients should avoid future use of the antibiotic to which they[ncbi.nlm.nih.gov] Biologics are newer drugs in the armamentarium that can be of benefit when baseline therapies do not work.[omicsonline.org]

  • Infectious Mononucleosis

    The persistent activation of T cells in our patient may have increased the likelihood of development of uncontrolled T-cell lymphoproliferative disease.[dx.doi.org] […] appeared to have developed drug hypersensitivity.[omicsonline.org] IM-like syndrome can be caused by various drugs, including SASP, and the concept of drug-induced hypersensitivity syndrome has been proposed recently.[ncbi.nlm.nih.gov]

  • Drug Hypersensitivity

    Areas covered: This article reviews the pathways of T-cell activation by drugs and how the ever increasing number of associations between expression of HLA alleles and susceptibility[ncbi.nlm.nih.gov] KEYWORDS: Drug hypersensitivity; IgE.; T-cells[ncbi.nlm.nih.gov] In the sulfamethoxazole model of p-i TCR, responsive T cells likely require costimulation for full T cell activation.[ncbi.nlm.nih.gov]

  • Churg-Strauss Syndrome

    cells revealed an increased proportion of CD3 and CD4 T cells. [10] These lymphocytes spontaneously release significant amounts of interleukin 5 (IL-5); this finding suggests[emedicine.medscape.com] Drug hypersensitivity—the ‘anticonvulsant syndrome’ Drug hypersensitivity is a potentially life-threatening syndrome with many possible clinical patterns and significant morbidity[kundoc.com] The etiology of Churg-Strauss syndrome is still unknown, but it has been attributed to hypersensitivity to an inhaled agent.[scielo.br]

  • Lyme Disease

    Besides B-lymphocytes and plasma cells, there is also a clonal accumulation of activated CD8 T cells in the CNS during early LNB ( 92 ).[doi.org] This lymphocyte subtype could be attracted by the local production of chemokines like CCL4, CCL5, CXCL10, or CXCL11 ( 82 ), as increased levels of all these chemokines have[doi.org]

  • Granulomatosis with Polyangiitis

    RESULTS: Frequency of CD4 CD8 double-positive T-cells was increased within the total CD3 T-cell population in GPA, but no difference was detected between patients with active[ncbi.nlm.nih.gov]

  • Muckle-Wells Syndrome

    […] the proline serine threonine phosphatase-interacting protein (PSTPIP1, or CD2 binding protein 1 [CD2BP1]) on chromosome 15, and the encoded cytoplasmic protein modulates T-cell[emedicine.medscape.com] These drugs help to inhibit the hypersensitive inflammatory response and relieve symptoms such as fever, joint pain, rash, eye redness/pain, and fatigue.[raregenomics.org] activation, cytoskeletal organization, and IL-1 beta release.[emedicine.medscape.com]

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