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12 Possible Causes for Drug-induced Cardiomyopathy, Dyspnea at Rest, Pulsus Alternans

  • Heart Failure

    Find out more Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?[eurheartj.oxfordjournals.org] These include, among others: Dyspnea ( exertional-, dyspnea at rest, orthopnea, paroxysmal nocturnal dyspnea); Fatigue, inadequate exhaustion after stress, weakness, lethargy[flexikon.doccheck.com] alternans (alternating large and small pulse pressures) and a raised JVP.[patient.info]

  • Congestive Heart Failure

    Initially dyspnea occurs only at exertion. Later on orthopnea and paroxysmal nocturnal dyspnea also develop. Later on dyspnea occurs even at rest.[symptoma.com] alternans (alternating large and small pulse pressures) and a raised JVP.[patient.info] Find out more Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?[eurheartj.oxfordjournals.org]

  • Myocardial Infarction

    Find out more Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?[eurheartj.oxfordjournals.org] Full text article Definition of hidden drug cardiotoxicity: paradigm change in cardiac safety testing and its clinical implications Full text article Febuxostat for Cerebral[eurheartj.oxfordjournals.org]

  • Dilated Cardiomyopathy

    Toxins-induced cardiomyopathy – the most common toxin is ethanol following by illegal drug abuse of cocaine and amphetamines.[escardio.org] At presentation she had dyspnea at rest, orthopnea and paroxysmal nocturnal dyspnea.[doi.org] Pulsus alternans is an infrequent, complex pathophysiologic sign often associated with severe heart failure.[ncbi.nlm.nih.gov]

  • Acute Myocarditis

    Case 1: A 48-years-old, previously healthy male patient admitted to our clinic with complaints of acute onset of rest dyspnea and orthopnea, started the day before.[ncbi.nlm.nih.gov] Drug-induced hypersensitivity syndrome due to mexiletine associated with human herpes virus 6 and cytomegalovirus reactivation.[scielo.br] Transformation of myocarditis and inflammatory cardiomyopathy to idiopathic dilated cardiomyopathy: facts and fiction.[scielo.br]

  • Alcoholic Cardiomyopathy

    There are five useful clinical signs to establish the presence and severity of cardiomyopathy: general appearance (cachexia and dyspnea at rest indicate severe impairment)[clevelandclinicmeded.com] Leg elevation promptly reversed the pulsus alternans, and the echocardiographic abnormality.[ncbi.nlm.nih.gov] Models, Animal Ethanol/toxicity Gene Expression Regulation/drug effects Heart Failure/chemically induced Heart Failure/genetics* Heart Failure/pathology Humans Mice Mitochondria[ncbi.nlm.nih.gov]

  • Toxic Myocarditis

    Viruses account for most cases of myocarditis or inflammatory cardiomyopathy, which could induce an immune response causing inflammation even when the pathogen has been cleared[revespcardiol.org] There are five useful clinical signs to establish the presence and severity of cardiomyopathy: general appearance (cachexia and dyspnea at rest indicate severe impairment)[clevelandclinicmeded.com] Other etiologic agents responsible for myocarditis include drugs, toxic substances, or autoimmune conditions.[revespcardiol.org]

  • Lymphocytic Myocarditis

    […] on exertion or at rest, or edema that could be dated specifically to a one-to-two-day period), and a history consistent with the presence of a viral illness within the two[nejm.org] Viruses account for most cases of myocarditis or inflammatory cardiomyopathy, which could induce an immune response causing inflammation even when the pathogen has been cleared[revespcardiol.org] […] features had to be present for histopathologically borderline or active myocarditis to be classified as fulminant: fever, distinct onset of symptoms of heart failure (fatigue, dyspnea[nejm.org]

  • Hemochromatosis-related Cardiomyopathy

    There are five useful clinical signs to establish the presence and severity of cardiomyopathy: general appearance (cachexia and dyspnea at rest indicate severe impairment)[clevelandclinicmeded.com] Toxins-induced cardiomyopathy – the most common toxin is ethanol following by illegal drug abuse of cocaine and amphetamines.[escardio.org] Medications-induced cardiomyopathy – the most pathogenic are chemotherapeutic agents such as anthracyclines, cyclophosphamide, and trastuzumab.[escardio.org]

  • High Output Heart Failure

    […] an alcoholic cardiomyopathy.[emedicine.medscape.com] Hypervolemia, dyspnea on rest or exertion, orthopnea, and fatigue are the general symptoms of heart failure.[ncbi.nlm.nih.gov] alternans (alternating large and small pulse pressures) and a raised JVP.[patient.info]