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19 Possible Causes for Drug-induced Cardiomyopathy, Impaired Exercise Tolerance

  • Acute Coronary Syndrome

    Viral related infections Chronic arrhythmia Thyroid dysfunction (hyper or hypothyroidism) Drug induced cardiomyopathies (particularly anthracycline related) Peripartum cardiomyopathies[heartonline.org.au] […] be familial Uncommon causes of heart failure with reduced ejection fraction include: Valvular heart disease (particularly mitral and aortic incompetence) Alcohol related cardiomyopathies[heartonline.org.au]

  • Congestive Heart Failure

    Find out more Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?[eurheartj.oxfordjournals.org] The impairment of exercise tolerance indicated by NYHA classification was markedly improved by PD for both groups.[ncbi.nlm.nih.gov] Numerous mechanisms unrelated to hemodynamic dysfunction may underlie impaired exercise tolerance in patients with chronic heart failure.[doi.org]

  • Heart Failure

    Find out more Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?[eurheartj.oxfordjournals.org] Numerous mechanisms unrelated to hemodynamic dysfunction may underlie impaired exercise tolerance in patients with chronic heart failure.[doi.org] Radhakrishnan V, Bakhshi S. 5-Fluorouracil-induced acute dilated cardiomyopathy in a pediatric patient.[doi.org]

  • Atrial Fibrillation

    (Level of Evidence: A) Class IIa Pharmacological therapy can be useful in patients with AF to maintain sinus rhythm and prevent tachycardia-induced cardiomyopathy.[doi.org] A rhythm-control strategy with pharmacological therapy can be useful in patients with AF for the treatment of tachycardia-induced cardiomyopathy.[onlinejacc.org] (Level of Evidence: C) Infrequent, well-tolerated recurrence of AF is reasonable as a successful outcome of antiarrhythmic drug therapy.[doi.org]

  • Dilated Cardiomyopathy

    Toxins-induced cardiomyopathy – the most common toxin is ethanol following by illegal drug abuse of cocaine and amphetamines.[escardio.org] cardiomyopathy Tachycardia-induced cardiomyopathy (TIC) is caused by sustained rapid ventricular rates and is one of the well-known forms of reversible myocardial diseases[ncbi.nlm.nih.gov] Medications-induced cardiomyopathy – the most pathogenic are chemotherapeutic agents such as anthracyclines, cyclophosphamide, and trastuzumab.[escardio.org]

  • Cystic Fibrosis

    […] to the potent oxidative stress induced by this drug.[ncbi.nlm.nih.gov] […] that is used for treating both hematologic and solid tumors, although severe cardiomyopathy and heart failure have been observed in adriamycin-treated cancer patients due[ncbi.nlm.nih.gov] […] index and increase the apoptotic index in tumor cells showing that it is not significantly effective (reducing tumor multiplicity by 57 ] Adriamycin is a potent anticancer drug[ncbi.nlm.nih.gov]

  • Acute Myocarditis

    Drug-induced hypersensitivity syndrome due to mexiletine associated with human herpes virus 6 and cytomegalovirus reactivation.[scielo.br] Transformation of myocarditis and inflammatory cardiomyopathy to idiopathic dilated cardiomyopathy: facts and fiction.[scielo.br]

  • Restrictive Cardiomyopathy

    Chloroquine (Hydroxychloroquine)-induced cardiomyopathy is a rare but potentially life-threatening condition.[ncbi.nlm.nih.gov] Cessation of the culprit drug, along with aggressive afterload reduction therapy, has been associated with halting of disease progress and even improvement in patients' clinical[ncbi.nlm.nih.gov]

  • Toxic Myocarditis

    Viruses account for most cases of myocarditis or inflammatory cardiomyopathy, which could induce an immune response causing inflammation even when the pathogen has been cleared[revespcardiol.org] Other etiologic agents responsible for myocarditis include drugs, toxic substances, or autoimmune conditions.[revespcardiol.org]

  • Hypersensitivity Myocarditis

    A prompt diagnosis, immediate withdrawal of the offending drug and immunosuppressant therapy may decrease mortality in drug-induced acute EM [ 1 ].[karger.com] Anthracycline-induced cardiomyopathy. Postgrad. Med. 2008, 120, 67–72. [ Google Scholar ] [ CrossRef ] [ PubMed ] Taliercio, C.P.; Olney, B.A.; Lie, J.T.[mdpi.com] In subacute and chronic EM, intracardiac thrombi, endomyocardial fibrosis and restrictive cardiomyopathy can be found.[karger.com]

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