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13 Possible Causes for Drug-induced Cardiomyopathy, Pulsus Alternans, Rales

  • Heart Failure

    Find out more Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?[eurheartj.oxfordjournals.org] alternans (alternating large and small pulse pressures) and a raised JVP.[patient.info] […] because of an inherited or acquired abnormality of cardiac structure and/or function, develop a constellation of clinical symptoms (dyspnea and fatigue) and signs (edema and rales[web.archive.org]

  • Congestive Heart Failure

    Find out more Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?[eurheartj.oxfordjournals.org] alternans (alternating large and small pulse pressures) and a raised JVP.[patient.info] No rales were detected because of its paucity of fibrous components in the lung.[ncbi.nlm.nih.gov]

  • Myocardial Infarction

    Find out more Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?[eurheartj.oxfordjournals.org] This patient had a clear history of carbon monoxide poisoning, acute respiratory distress, bilateral lung dry and moist rale, chest X-ray showed bilateral pulmonary edema,[ncbi.nlm.nih.gov] (RALES and EMPHASIS-HF) and of renal function degradation (EMPHASIS-HF).[doi.org]

  • Acute Myocarditis

    Drug-induced hypersensitivity syndrome due to mexiletine associated with human herpes virus 6 and cytomegalovirus reactivation.[scielo.br] Physical exam will look like congestive heart failure, with jugular venous distention, pulmonary rales, peripheral edema, pulsatile liver, and perhaps a laterally displaced[clinicaladvisor.com] The arterial pressure was 89x56 and MAP of 67 mmHg, there was a gallop rhythm with rales in both lung fields.[scielo.br]

  • Hypersensitivity Myocarditis

    A prompt diagnosis, immediate withdrawal of the offending drug and immunosuppressant therapy may decrease mortality in drug-induced acute EM [ 1 ].[karger.com] The lung fields had rales at both bases without audible wheezes. Internal jugular venous pulsations were 5 cm above the sternal notch.[ncbi.nlm.nih.gov] There was enlargement and tenderness of the liver, a positive hepatojugular reflux, bilateral rales, and an S 3 gallop with no murmurs.[nejm.org]

  • High Output Heart Failure

    […] an alcoholic cardiomyopathy.[emedicine.medscape.com] alternans (alternating large and small pulse pressures) and a raised JVP.[patient.info] Patients with high output heart failure present with dyspnea, tachypnea, non-productive cough, fatigability, pulmonary rales, pleural effusion and peripheral edema, as a result[symptoma.com]

  • Dilated Cardiomyopathy

    Toxins-induced cardiomyopathy – the most common toxin is ethanol following by illegal drug abuse of cocaine and amphetamines.[escardio.org] Pulsus alternans is an infrequent, complex pathophysiologic sign often associated with severe heart failure.[ncbi.nlm.nih.gov] There were moist rales in the lung fields and chest wall retraction. The abdominal exam revealed hepatomegaly.[revportcardiol.org]

  • Alcoholic Cardiomyopathy

    Models, Animal Ethanol/toxicity Gene Expression Regulation/drug effects Heart Failure/chemically induced Heart Failure/genetics* Heart Failure/pathology Humans Mice Mitochondria[ncbi.nlm.nih.gov] Leg elevation promptly reversed the pulsus alternans, and the echocardiographic abnormality.[ncbi.nlm.nih.gov] Respiratory sound was bilateral rough and moist rales were heard in bilateral lower lung.[jtd.amegroups.com]

  • Toxic Myocarditis

    Viruses account for most cases of myocarditis or inflammatory cardiomyopathy, which could induce an immune response causing inflammation even when the pathogen has been cleared[revespcardiol.org] All patients presented with tachypnoea, tachycardia, sweating, gallop rhythm, pulmonary wheezing, rales and hepatomegaly.[bestbets.org] Physical findings: Pulmonary congestion: tachypnea, grunting, nasal flaring, rales Low cardiac output: tachycardia, poor perfusion, hypotension Muffled heart sounds Hepatomegaly[clinicaladvisor.com]

  • Hemochromatosis-related Cardiomyopathy

    Toxins-induced cardiomyopathy – the most common toxin is ethanol following by illegal drug abuse of cocaine and amphetamines.[escardio.org] There were bibasilar rales on auscultation of the lungs and no wheezing.[karger.com] Medications-induced cardiomyopathy – the most pathogenic are chemotherapeutic agents such as anthracyclines, cyclophosphamide, and trastuzumab.[escardio.org]

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