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12 Possible Causes for Drug-induced Cardiomyopathy, Pulsus Alternans, T Wave Inversion

  • Myocardial Infarction

    Electrocardiography showed a sinus rhythm with Q-wave formation in the inferior wall leads (II, III, aVF), T-wave inversion in the same leads, and borderline QT prolongation[ncbi.nlm.nih.gov] Find out more Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?[eurheartj.oxfordjournals.org] ST segment depression and T wave inversion are associated with subendocardial infarction.[histopathology-india.net]

  • Dilated Cardiomyopathy

    Takotsubo cardiomyopathy is characterized by the basal hypercontractility and apical ballooning of the left ventriculum and T-wave inversion in the electrocardiogram.[ncbi.nlm.nih.gov] Toxins-induced cardiomyopathy – the most common toxin is ethanol following by illegal drug abuse of cocaine and amphetamines.[escardio.org] Pulsus alternans is an infrequent, complex pathophysiologic sign often associated with severe heart failure.[ncbi.nlm.nih.gov]

  • Acute Myocarditis

    Drug-induced hypersensitivity syndrome due to mexiletine associated with human herpes virus 6 and cytomegalovirus reactivation.[scielo.br] Abstract BACKGROUND: The pathophysiologic mechanisms and the prognostic meaning of electrocardiographic (ECG) T-wave inversion (TWI) occurring in a subgroup of patients with[ncbi.nlm.nih.gov] Thereafter, T-wave inversion typically ensues. The T-wave inversion may be discrete and lasts for one month.[ecgwaves.com]

  • Hypersensitivity Myocarditis

    A prompt diagnosis, immediate withdrawal of the offending drug and immunosuppressant therapy may decrease mortality in drug-induced acute EM [ 1 ].[karger.com] Physical agents Electric shock Hyperpyrexia Radiation/radiotherapy Investigations ECG: changes may include ST-segment elevation/depression, T-wave inversion, atrial arrhythmias[patient.info] Electrocardiography showed diffuse depression of the ST segment, inversion of the T wave, Q waves in leads V 1 and V 2 , and frequent premature ventricular contractions.[nejm.org]

  • Lymphocytic Myocarditis

    Viruses account for most cases of myocarditis or inflammatory cardiomyopathy, which could induce an immune response causing inflammation even when the pathogen has been cleared[revespcardiol.org] Markers of myocardial damage ( troponin or creatine kinase cardiac isoenzymes) are elevated. [10] The ECG findings most commonly seen in myocarditis are diffuse T wave inversions[en.wikipedia.org] Other etiologic agents responsible for myocarditis include drugs, toxic substances, or autoimmune conditions.[revespcardiol.org]

  • Alcoholic Cardiomyopathy

    Leg elevation promptly reversed the pulsus alternans, and the echocardiographic abnormality.[ncbi.nlm.nih.gov] Models, Animal Ethanol/toxicity Gene Expression Regulation/drug effects Heart Failure/chemically induced Heart Failure/genetics* Heart Failure/pathology Humans Mice Mitochondria[ncbi.nlm.nih.gov] Application of a small dose of glyceryl trinitrate paste (0.25 in) resulted in severe left ventricular dysfunction with the appearance of pulsus alternans in a patient with[ncbi.nlm.nih.gov]

  • Hemochromatosis-related Cardiomyopathy

    Toxins-induced cardiomyopathy – the most common toxin is ethanol following by illegal drug abuse of cocaine and amphetamines.[escardio.org] inversion in leads I and aVL ( 3mm) (with QRS–T wave axis difference 30 ), V3–V6 ( 3mm) or II and III and aVF ( 5mm) Abnormal Q ( 40 ms or 25% R wave) in at least two leads[textbookofcardiology.org] Medications-induced cardiomyopathy – the most pathogenic are chemotherapeutic agents such as anthracyclines, cyclophosphamide, and trastuzumab.[escardio.org]

  • Toxic Myocarditis

    Viruses account for most cases of myocarditis or inflammatory cardiomyopathy, which could induce an immune response causing inflammation even when the pathogen has been cleared[revespcardiol.org] Thereafter, T-wave inversion typically ensues. The T-wave inversion may be discrete and lasts for one month.[ecgwaves.com] Diffuse T wave inversion. Ventricular arrhythmias. AV conduction defects.[lifeinthefastlane.com]

  • Heart Failure

    inversion (the "cerebral T-wave").[ncbi.nlm.nih.gov] Find out more Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?[eurheartj.oxfordjournals.org] alternans (alternating large and small pulse pressures) and a raised JVP.[patient.info]

  • Ventricular Bigeminy

    Although this 15-lead EKG shows only non-specific T-wave inversion in V4R, the posterior leads V7 and V8 demonstrate subtle ST elevation, thus confirming what can be suspected[thejarvik7.wordpress.com] Premature ventricular contraction-induced concealed mechanical bradycardia and dilated cardiomyopathy . J Cardiovasc Electrophysiol. 2005 ; 16: 88 – 91 .[tandfonline.com] alternans or trigeminus R00.8 Trigeminy R00.8 ICD-10-CM Codes Adjacent To R00.8 Q99 Other chromosome abnormalities, not elsewhere classified Q99.0 Chimera 46, XX/46, XY Q99.1[icd10data.com]

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