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21 Possible Causes for Drug-induced Hypercalcemia, Pruritus

  • Vitamin D Toxicity

    Anorexia, nausea, and vomiting can develop, often followed by polyuria, polydipsia, weakness, nervousness, pruritus, and eventually renal failure.[] Vomiting Malaise Hepatosplenomegaly Liver failure Raised intracranial pressure Children can present with craniotabes, irritability, failure to thrive, decreased appetite and pruritus[]

  • Milk-Alkali Syndrome

    Patients with a prolonged course of disease may experience muscle aches, tremor, polyuria, polydipsia, and pruritus.[] Patients often complained of pruritus and diffuse musculoskeletal symptoms.[] Patients with more severe hypercalcemia may present with polydipsia, polyuria, conjunctivitis, muscle aches and pruritus.[]

  • Hypervitaminosis A

    The clinical features included irritability, xerosis of the skin and mucous membranes, pruritus, bone pain, and loss of ambulation.[] Acute pseudotumour cerebri Chronic pruritus, dry skin, dry lips soft tissue nodules diffuse symmetric periostitis (scintigraphy may allow earlier detection 2 ) may cause premature[] Pruritus (itching). Bulging fontanelles. Acute hypervitaminosis A (such as consumption of a single large dose of 30- 60 mg of vitamin A) may lead to Nausea. Vomiting.[]

  • Calcitriol

    Drug: thiazide diuretics may cause hypercalcemia; calcifediol-induced hypercalcemia may precipitate digitalis arrhythmias in patients receiving digitalis glycosides.[] Excessive vitamin D intake (late manifestations): Polyuria, polydipsia, anorexia, weight loss, nocturia, calcific conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritus[] Interactions Drug-drug. Antacids containing magnesium: May induce hypermagnesemia, especially in patients with chronic renal failure. Avoid use together.[]

  • Calcium Gluconate

    […] also been employed to decrease capillary permeability in allergic conditions, nonthrombocytopenic purpura and exudative dermatoses such as dermatitis herpetiformis and for pruritus[] Late : Polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated[]

  • Vitamin D

    Less frequent causes are granulomatous diseases, drug-induced diseases, and intoxications. Case report.[] […] in patients undergoing hemodialysis, administration of ergocalciferol (vitamin D 2 ) was explored in 50 patients with uremic pruritus.[] Anorexia, nausea, and vomiting can develop, often followed by polyuria, polydipsia, weakness, nervousness, pruritus, and eventually renal failure.[]

  • Anabolic Steroid

    The main cause of renal dysfunction in these cases seems to be the vitamin D intoxication and drug-induced interstitial nephritis.[] We report four cases of patients with pruritus, abnormal liver function tests and biopsy-proven anabolic steroid-induced cholestasis who were unresponsive to SMT.[] It is mandatory to start early treatment for serious hypercalcemia, with vigorous venous hydration, diuretics and corticosteroids.[]

  • Calcifediol

    Skin: pruritus, photosensitivity. Other: hyperthermia, decreased libido. Effects on lab test results None reported.[]

  • Calcium Glubionate

    […] ipsilateral drug-related micronutrients occurred with an of stiffer than 1%, and frequently were foraging dermatitis, ipecac of administrative dermatitis, paople of legs, pruritus[]

  • Hypercalcemia

    Coccidioidomycosis Histoplasmosis Leprosy Silicosis TB Other disorders Milk-alkali syndrome Vitamin D toxicity Elevated plasma protein concentration: Uncertain mechanism Drugs[] She had been taking cinacalcet for 1 month but was experiencing pruritus, so the medication was discontinued.[] Indeed, dosedependent effects have been reported in fluconazole-associated drug interactions and toxicities [ 19 - 23 ].[]

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