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21 Possible Causes for Dry Cough, Peripheral T Cells Decreased, Pertussis

  • Influenza

    OBJECTIVES: Influenza and pertussis vaccination programmes have been in place for pregnant women in the UK since 2009 and 2012, respectively.[ncbi.nlm.nih.gov] The dry cough and fatigue of influenza can last two to three weeks. Signs that influenza is getting worse include fever, shaking chills, and shortness of breath.[my.clevelandclinic.org] In contrast, IL-1R1 / mice showed a dramatic decrease in CD4 T-cell proliferation, suggesting that efficient T-helper cell priming in peripheral organs is dependent on a functional[dx.doi.org]

  • Asthma

    Bordetella pertussis positive individuals had lower FEV 1 /FVC (77.1% v 80.7%, p   0.012) and more asthma symptoms than B pertussis negative cases.[dx.doi.org] Despite the patient presenting asthma characteristics (expiratory wheezing, dry cough, partial reversibility at post bronchodilator test) and asthma medication alleviating[ncbi.nlm.nih.gov] RT‑qPCR demonstrated that VDR expression in the peripheral blood of asthmatic children was decreased.[ncbi.nlm.nih.gov]

  • Adenovirus Infection

    "Guard Against Pertussis." Contemporary Pediatrics (February 2003): 87. Kolavic-Gray, Shellie A., et al.[medical-dictionary.thefreedictionary.com] cough Fever lasting 2 to 4 days Illness subsiding in 10 to 14 days DDx: rhinovirus, influenza, parainfluenza, RSV Viral pneumonia Sudden onset of high fever, rapid infection[unboundmedicine.com] Appearance of virus-specific CD4 T cells in peripheral blood and a rise of neutralizing antibody titres specific for the HAdV serotype infecting the patient could be demonstrated[nature.com]

  • Food Allergy

    Compared with infants who receive aP as their first pertussis vaccine, those who receive wP appear less likely to mount Th2 immune responses to either vaccine or extraneous[ncbi.nlm.nih.gov] cough Odd taste in mouth Severe symptoms may include one or more of the following Swelling of the lips, tongue, and/or throat that blocks breathing Trouble swallowing Shortness[foodallergy.org] This causes low FOXP3 mRNA levels and markedly decreased protein expression in peripheral blood lymphocytes of affected patients.[ncbi.nlm.nih.gov]

  • Graft-versus-Host-Disease

    Specific pathogens of interest include pneumococci, Haemophilus influenzae B, Chlamydia pneumoniae , Mycoplasma pneumoniae , Toxoplasma gondii , Bordetella pertussis , Mycobaterium[nature.com] cough pulmonary cGvHD — of the lungs) Difficulty swallowing, pain with swallowing, or weight loss (signs of cGvHD of the gastrointestinal tract or “gut”) Fatigue, muscle[my.clevelandclinic.org] These cells induce allogeneic T cell death in response to interferon-γ, resulting in regulatory T cell expansion and immunosuppression.[stm.sciencemag.org]

  • Good's Syndrome

    Bordetella pertussis may rarely play an important role in respiratory infections. IgG2 is the predominant isotype of antibodies produced in response to polysaccharides.[emedicine.medscape.com] A complex medical history became even more tangled when a 52-year-old man presented with a 4-week history of dry cough, dyspnea, weight loss, chills, subcutaneous nodules[amjmed.org] Flow cytometry of peripheral blood lym-phocyte revealed markedly reduced peripheral B cells, CD4 T-cell lymphopenia, inverted CD4/CD8 T-cell-ratio 0.37 (CD4--20.82%, CD8--[ncbi.nlm.nih.gov]

  • Multiple Sclerosis

    Philpott, The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1β Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis, PLoS Pathogens[dx.doi.org] If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment: hives rash itching difficulty breathing or swallowing dry cough nausea[nlm.nih.gov] Immunologic changes included a marked decrease in proliferation of interferon γ–producing myelin-reactive CD4 T cells in peripheral blood and decreased titers of myelin-specific[oadoi.org]

  • Acquired Immunodeficiency Syndrome

    Pertussis, also known as whooping cough, is a highly contagious respiratory disease. It is caused by the bacterium Bordetella pertussis.[niaid.nih.gov] cough and shortness of breath  Shaking chills or fever higher than 100 F (38 C) for several weeks 14.  Persistent white spots or unusual lesions on tongue or in face [slideshare.net] Monoclonal antibody analysis of peripheral-blood T-cell subsets revealed a marked decrease of the T-helper cell subset with inversion of the normal ratio of T-helper to T-suppressor[cdc.gov]

  • Leishmaniasis

    During the 2008–2012 pertussis epidemic in Australia, pertactin (Prn)–negative Bordetella pertussis emerged.[cdc.gov] He had dry cough of one month duration associated with small amount of haemoptysis and oral ulceration more marked on the tongue.[casesjournal.biomedcentral.com] By contrast, peripheral immunity is controlled mostly by CD8 T cells that are the major sources of IL-10 and are anergic in nature [ 68 ].[doi.org]

  • Hematopoietic Stem Cell Transplantation

    6 mo Influenza vaccination each autumn ... 12 mo Commence if no evidence of active or chronic GVHD observed 3 doses at intervals of 1-2 mo: diphtheria/tetanus/acellular pertussis[emedicine.medscape.com] cough at six months post-transplantation based on the findings of laryngoscopy and fiberoptic bronchoscopy.[ncbi.nlm.nih.gov] Ten patients with symptomatic SCD underwent CD34 cell-selected, T-cell–depleted peripheral blood stem cell transplantation from a mismatched family member or unrelated donor[bloodadvances.org]

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