Dry Tap Bone Marrow: Causes & Reasons

Possible Causes for Dry Tap Bone Marrow

She was subjected to bone marrow examination. Bone marrow aspiration revealed a dry tap. [ijcasereportsandimages.com]

marrow aspiration gives a ‘dry tap’ – no cells are obtained Bone marrow biopsy reveals fibrosis of bone marrow Peripheral smear anemia – normocytic, normochromic leukoerythroblastosis [pgblazer.com]

This is known as a ‘dry tap’. The bone marrow trephine biopsy typically shows abnormal fibrosis of the marrow cavity. [leukaemia.org.au]

Primary Myelofibrosis

This is known as a ‘dry tap’. The bone marrow trephine biopsy typically shows abnormal fibrosis of the marrow cavity. [leukaemia.org.au]

However, as mentioned, these studies may be difficult to obtain due to “dry tap” on bone marrow aspirates in over 50% of patients with primary myelofibrosis. [askhematologist.com]

Bone marrow examination It is frequently impossible to obtain any samples of bone marrow fluid using a needle and syringe (bone marrow aspiration) due to marrow fibrosis. [leukaemia.org.au]

Hairy Cell Leukemia

The diagnosis is best made on a bone marrow biopsy as an increase in reticulin fibers is present with hairy cell infiltrates in the bone marrow and often results in a "dry [path.upmc.edu]

marrow aspirate dry tap due to marrow fibrosis increased reticulin CBC anemia thrombocytopenia leukopenia Differential Diagnosis Non-Hodgkin lymphoma Mantle cell lymphoma [step2.medbullets.com]

The extent of bone marrow effacement in hairy cell leukemia is variable. [path.upmc.edu]

Philadelphia Chromosome-Positive Chronic Myeloid Leukemia

Immunophenotypic analysis of cells isolated from bone marrow biopsies in patients with failed bone marrow aspiration (“dry tap”). Am J Clin Pathol. 1990;93(4):545–548. [archivesofpathology.org]

A bone marrow biopsy was performed; the aspirate was unsuccessful (“dry tap”) but the biopsy material showed a fibrotic bone marrow with atypical megakaryocytes and megakaryoblasts [archivesofpathology.org]

This method yields cell suspensions from a dry-tap bone marrow core biopsy that may be used for Giemsa staining, flow cytometry, and cytogenetics. [archivesofpathology.org]

Acute Leukemia

Bone marrow dry tap is common. Bone marrow biopsy show increased fibroblasts and/or increased reticulin and presence of greater than 30% blast cells. [intechopen.com]

[…] although on occasion a “dry tap” can also be due to the patient’s marrow pathology. [bcmj.org]

Two common problems are a marrow biopsy sample consisting mainly of cortical bone and a hemodilute marrow aspirate lacking marrow particles and consisting mainly of blood, [bcmj.org]

Acute Panmyelosis with Myelofibrosis

As a consequence of myelofibrosis and dry tap, bone marrow cytology and cytogenetic analyses are only available in a minority of cases. [bloodjournal.org]

Bone marrow aspirate resulted in a dry tap. [ncbi.nlm.nih.gov]

Bone marrow aspirate was a dry tap. Bone marrow biopsy showed increased cellularity with panmyelosis [Figure 2]. [ajmhs.org]

Bone Marrow Aspiration

Abstract Naturally trephine biopsies have definitive advantages over aspirates in case of dry tap bone marrow aspirates as a result of fibrosis or densely packed bone marrow [ncbi.nlm.nih.gov]

What is dry tap? The bone marrow is not obtained on aspiration. Seen in aplastic anemia and myelofibrosis. Faulty technique also results in dry tap. [ilovepathology.com]

Bone marrow aspiration was not diagnostic due to dry tap or inadequate material in 6 cases. [bmccancer.biomedcentral.com]

Leukoerythroblastic Anemia

However, as mentioned, these studies may be difficult to obtain due to “ dry tap ” on bone marrow aspirates in over 50% of patients with primary myelofibrosis. [askhematologist.com]

[…] osteosclerosis with irregular, broad bony trabeculae; markedly dilated sinuses; associated with dry bone marrow taps Spleen : red pulp sinuses contain megakaryocytes, granulocyte [pathologyoutlines.com]

Bone marrow aspiration was a dry tap with poorly cellular touch smears. [ijpmonline.org]

Autosomal Recessive Osteopetrosis Type 1

The initial bone marrow evaluation resulted in a dry tap. On marrow blood, no blasts, Gaucher cells, or Niemann-Pick cells were identified. [scielo.org.mx]

Acute Megakaryocytic Leukemia

Bone marrow aspiration returned dry tap. Bone marrow biopsy done showed normal bony trabeculae with fibrotic marrow spaces with normal hematopoisis suppressed. [ijpmonline.org]

Bone marrow aspirate was a dry tap. Bone marrow biopsy showed increased cellularity with panmyelosis [Figure 2]. [ajmhs.org]

The first bone marrow aspirate was a dry tap. [dovepress.com]

Myelofibrosis

This is known as a ‘dry tap’. The bone marrow trephine biopsy typically shows abnormal fibrosis of the marrow cavity. [leukaemia.org.au]

However, these studies may be difficult to obtain due to "dry tap" on bone marrow aspirates in over 50% of patients with primary myelofibrosis. [emedicine.medscape.com]

Myopia Type 22

Repeated attempts at bone marrow aspiration yielded dry tap on each occasion. [wajradiology.org]

Sclerotic bony changes and marrow fibrosis leads to a dry bone marrow tap as was encountered in our case. [wajradiology.org]

The infantogram revealed a generalized increase in bone density with loss of corticomedullary differentiation [Figure 1]. [wajradiology.org]

Osteopetrosis

Bone marrow aspiration was dry tap. [alliedacademies.org]

The results of bone marrow studies are shown in [Table 4]. Bone marrow aspirate was dry tap in all seven cases. [ijpmonline.org]

Bone marrow aspiration in such cases is difficult and usually leads to dry tap. Trephine biopsy is essential in these cases to obtain bone marrow picture. [alliedacademies.org]

Autosomal Recessive Osteopetrosis Type 6

Repeated attempts at bone marrow aspiration yielded dry tap on each occasion. [wajradiology.org]

The initial bone marrow evaluation resulted in a dry tap. On marrow blood, no blasts, Gaucher cells, or Niemann-Pick cells were identified. [scielo.org.mx]

Sclerotic bony changes and marrow fibrosis leads to a dry bone marrow tap as was encountered in our case. [wajradiology.org]

Pathological Retraction Ring of the Uterus

Massive Splenomegaly : Due to infiltration of hairy cells into spleen Pancytopenia Dry Tap: Bone-marrow tap is dry, due to reactive fibrosis in the bone marrow. [kumc.edu]

Dry Tap: Bone-marrow tap is difficult to do and is almost always dry, due to fibrosis in marrow. TREATMENT: No specific treatment. [kumc.edu]

This distinguishes Myelofibrosis from Hair Cell Leukemia, which shows splenomegaly, dry tap, and leukopenia. Massive Splenomegaly: The biggest spleens you'll ever see. [kumc.edu]

Unclassified Chronic Myeloproliferative Disease

Disorders: It All Makes Sense.ASH Education Book 2005,p 49 IMF: Diagnosis Typical blood findings Splenomegaly Bone marrow Dry tap aspirate Bone marrow fibrosis and megakaryocytic [slideplayer.com]

marrow : Aspiration : Dry tap Biopsy: Increased fibrosis and megakaryopoesis JAK2 mutation:50%** ** Kenneth Kaushansky, On the Molecular Origins of the Chronic Myeloproliferative [slideplayer.com]

[…] teardrop shapes Leuko-erythroblastic : erythroblasts + young myeloid cells* *(promyelocytes, myelocytes, meta, band and polys.) 47 48 IMF: LAB LDH, uric acid: increased Bone [slideplayer.com]

Hairy Cell Leukemia Variant

Monocytopenia is constant, lymphadenopathy is rare and the bone marrow is "dry tap" in most cases. [atlasgeneticsoncology.org]

• definitive diagnosis usually requires a bone marrow trephine biopsy due to the high frequency of a dry tap on aspiration • IHC on paraffin section: TRAP stain, CD20, CD72 [slideshare.net]

Bone marrow is often unable to be aspirated, resulting in a “dry tap.” [clinicalgate.com]

Autosomal Recessive Osteopetrosis Type 8

The initial bone marrow evaluation resulted in a dry tap. On marrow blood, no blasts, Gaucher cells, or Niemann-Pick cells were identified. [scielo.org.mx]

Myeloid Metaplasia

bone marrow tap in 10 patients and cellular marrow aspirate with prominence of megakaryocytes dispersed in a maturing cell population of myeloid and erythroid series in 4 [ncbi.nlm.nih.gov]

The bone marrow aspirate in almost every patient yields a "dry tap," even when the marrow biopsy is highly cellular. [clicktocurecancer.info]

Successful bone marrow aspiration is unusual, with a dry tap occurring in 80% of cases. [cancertherapyadvisor.com]

Familial Myelofibrosis

Usually, only a few cells can be obtained by bone marrow aspiration as it results in a dry tap. [symptoma.com]

The bone marrow aspirate sampled was a “dry tap,” but the biopsy was markedly hypercellular (cellularity 95%) with megakaryocytic hyperplasia (>10 megakaryocytes/hpf) and [hindawi.com]

Pancytopenia and leukoerythroblastosis require further clarification and should prompt a bone marrow biopsy. [symptoma.com]

Autosomal Recessive Osteopetrosis Type 7

Repeated attempts at bone marrow aspiration yielded dry tap on each occasion. [wajradiology.org]

However, Horton et al reported that the histologic features in the malignant and mild recessive forms are distinct, suggesting a different pathogenesis.12 A dry tap on bone [annsaudimed.net]

Sclerotic bony changes and marrow fibrosis leads to a dry bone marrow tap as was encountered in our case. [wajradiology.org]

Autosomal Dominant Osteopetrosis Type 2

Bone marrow aspiration was dry tap. [alliedacademies.org]

Bone marrow aspiration in such cases is difficult and usually leads to dry tap. Trephine biopsy is essential in these cases to obtain bone marrow picture. [alliedacademies.org]

Based on peripheral smear finding, bone marrow aspiration and biopsy was advised and was obtained from posterior superior iliac spine. [alliedacademies.org]

Myelodysplasia

Bone marrow aspirates resulted in a dry tap. Bone marrow biopsy showed a hypercellular marrow with reduced erythroid elements. [scielo.br]

Screening FISH (5q−, −7, +8) from peripheral blood may be performed in patients of dry tap bone marrow and this may influence management of the patient [19]. [intechopen.com]

However, this is often associated with a ‘dry tap’ secondary to marked bone marrow fibrosis and a bone marrow trephine may be necessary to confirm ML-DS—it is not clear that [doi.org]

Ghosal Syndrome

Multiple bone marrow aspirations were dry tap. However, bone marrow biopsy revealed myelofibrosis. [learningcenter.ehaweb.org]

Hypovolemic Shock

Bone marrow aspiration was attempted to evaluate the disease state but the tap was dry. Therefore, bone marrow biopsy was conducted from the ilium (Figure 2 ). [oadoi.org]

Myelophthisis

[…] biopsy or aspiration is best performed in areas with tender bone, and inability to aspirate marrow from such a tender bone (dry tap) leads to a high degree of suspicion of [medtextfree.wordpress.com]

marrow replacement. [medtextfree.wordpress.com]

[…] aspirations are also of value14 but may not provide the same yield of tumor cells and can be difficult to interpret in patients with agnogenic or secondary myelofibrosis.15 Marrow [medtextfree.wordpress.com]

Lymphoproliferative Disorder

HAIRY CELL LEUKEMIA Pancytopenia Circulating hairy cells Bone marrow dry tap TRAP+ CD19+,CD5-,CD20+ strong 27. 5. [slideshare.net]

 Bone marrow aspiration- DRY TAP  Bone marrow biopsy- monotonous infiltrate of abnormal lymphocytes with small nuclei and abundant pale-staining cytoplasm- FRIED EGG APPEARANCE [slideshare.net]

Myopia Type 17

Repeated attempts at bone marrow aspiration yielded dry tap on each occasion. [wajradiology.org]

Sclerotic bony changes and marrow fibrosis leads to a dry bone marrow tap as was encountered in our case. [wajradiology.org]

The infantogram revealed a generalized increase in bone density with loss of corticomedullary differentiation [Figure 1]. [wajradiology.org]

B-Cell Acute Lymphoblastic Leukemia

Performing bone marrow aspiration in this patient was difficult (a "dry tap"), and the diagnosis was established by means of a bone marrow biopsy and immunohistopathologic [ncbi.nlm.nih.gov]

Benign Papilloma of the Ureter

Massive Splenomegaly : Due to infiltration of hairy cells into spleen Pancytopenia Dry Tap: Bone-marrow tap is dry, due to reactive fibrosis in the bone marrow. [kumc.edu]

Dry Tap: Bone-marrow tap is difficult to do and is almost always dry, due to fibrosis in marrow. TREATMENT: No specific treatment. [kumc.edu]

This distinguishes Myelofibrosis from Hair Cell Leukemia, which shows splenomegaly, dry tap, and leukopenia. Massive Splenomegaly: The biggest spleens you'll ever see. [kumc.edu]