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1,501 Possible Causes for Dull Facial Expression, Macroglossia, Wide Space Between the First and Second Toe

  • Down Syndrome

    Dental malocclusion and macroglossia are associated. Technical modifications to increase macroglossia surgery safety and efficacy have been described.[doi.org] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] spacing, often with a deep plantar groove between the first and second toes.[dx.doi.org]

  • Myxedema

    Macroglossia is classified as true macroglossia, which exhibits abnormal histology with clinical findings, and relative macroglossia, in which normal histology does not correlate[ncbi.nlm.nih.gov] The patient loses facial expression, and an appearance of imbecility is quickly observed.[henriettes-herb.com] […] care -If thyroid labs don’t come back in timely fashion, proceed with thyroid replacement -CK is often elevated -Potentially challenging intubation: oropharyngeal edema, macroglossia[emdocs.net]

    Missing: Wide Space Between the First and Second Toe
  • Juvenile Myxedema

    There is dwarfism, macroglossia and mental dullness. iatrogenic hypothyroidism may follow treatment for hyperparathyroidism in cats. juvenile hypothyroidism congenital hypothyroidism[medical-dictionary.thefreedictionary.com] […] frequency of crying Constipation Signs Large fontanelles Myxoedema - with coarse features and a large head and oedema of the genitalia and extremities Nasal obstruction Macroglossia[patient.info] ORAL MANIFESTATIONS Symptoms  Teeth  Jaw bone  Palate  Macroglossia  Lips Radiological features  Skull changes  Air sinuses  Teeth  Jaw bone 11.    Surgery- trans[slideshare.net]

    Missing: Wide Space Between the First and Second Toe
  • Congenital Hypothyroidism

    Coarse facies, macroglossia, constipation, and short trunk may become evident either during or beyond the neonatal period.[currentpediatrics.com] […] features include decreased activity and increased sleep, feeding difficulty and constipation, prolonged jaundice, myxedematous facies, large fontanels (especially posterior), macroglossia[orpha.net] The most common presentation includes cold or mottled skin, macroglossia or umbilical hernia seen at the initial examination.[symptoma.com]

    Missing: Wide Space Between the First and Second Toe
  • Sporadic Goitrous Cretinism

    Cretinism  Fetal or infantile hypothyroidism  Endemic and sporadic  Sporadic –agenesis ,dyshormonogenesis  Hoarse cry, macroglossia, umbilical hernia  Immediate diagnosis[slideshare.net] Macroglossia may be due to tumor; eg, lymphangioma. The dry skin of ichthyosis may be misleading.[generalhealthtopics.com] The physical examination may reveal failure to thrive, large anterior and post fontanelles, dry skin, jaundice (usually prolonged), mottling, umbilical hernia, macroglossia[omicsonline.org]

    Missing: Wide Space Between the First and Second Toe
  • Multiple Endocrine Neoplasia Type 2B

    Between ages 2 and 4, they develop full lips, large rounded cheeks , a broad nose , and an enlarged tongue ( macroglossia ).[ghr.nlm.nih.gov] Figure 3 The first toe is longer than the others and there is a wide space between the first and second toe.[ijponline.biomedcentral.com] The first toe is longer than the others and there is a wide space between the first and second toe (Figure 3 ).[ijponline.biomedcentral.com]

    Missing: Dull Facial Expression
  • Hypothyroidism

    Secondary hypothyroidism is characterized by skin and hair that are dry but not very coarse, skin depigmentation, only minimal macroglossia, atrophic breasts, and low BP.[merckmanuals.com] Symptoms include dull facial expressions, tiredness, and weight gain. Blood tests can help diagnose this condition.[cedars-sinai.edu] Individuals can also present with obstructive sleep apnea (secondary to macroglossia) or carpal tunnel syndrome.[emedicine.medscape.com]

    Missing: Wide Space Between the First and Second Toe
  • Myxedema Coma

    She had periorbital edema and macroglossia, and her thyroid was not palpable; she also had pitting edema in her lower legs.[nejm.org] dull.[merckmanuals.com] Note the facial and periorbital puffiness and the dull, lethargic expression.[aneskey.com]

    Missing: Wide Space Between the First and Second Toe
  • Allergic Rhinitis

    Local allergic rhinitis is a newly described type of rhinitis involving nasal production of specific immunoglobulin (slg) E antibodies in the absence of atopy. It can affect patients previously diagnosed with non-allergic rhinitis. Evidence for this entity is supported by clinical symptoms, local production of slgE, a type 2[…][ncbi.nlm.nih.gov]

    Missing: Macroglossia Wide Space Between the First and Second Toe
  • Genee-Wiedemann Syndrome

    […] repair in neonates, endotracheal intubation for insufficient airway, and use of specialized nipples or nasogastric tube feedings to manage feeding difficulties resulting from macroglossia[checkorphan.org] He had a wide space between the first and second toe of his feet and subungual fibroma on the second and third toe of the right foot and on the third toe of the left foot.[jmg.bmj.com] On examination, there was enlarged tongue (macroglossia) with left side hemihypertrophy.[jcnonweb.com]

    Missing: Dull Facial Expression

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