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1,058 Possible Causes for Duplication or Triplication of Phalanges, Hyperextensible Joints, Wide Space Between the First and Second Toe

  • Down Syndrome

    hyperextensibility or hyperflexibility Neuromuscular hypotonia Diastasis recti Dry skin Premature aging Congenital heart defects Complications of Down syndrome can involve[emedicine.medscape.com] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] spacing, often with a deep plantar groove between the first and second toes.[dx.doi.org]

    Missing: Duplication or Triplication of Phalanges
  • Kleiner Holmes Syndrome

    […] gap between first and second toes Wide space between 1st, 2nd toes Wide space between first and second toes Widely spaced 1st-2nd toes Widely spaced first and second toes[rarediseases.info.nih.gov] Radiographs show broad, shortened, misshapen first metatarsals and may associate incomplete or complete duplication of proximal phalanges and duplication or triplication of[malacards.org] […] gap between first and second toes Wide space between 1st, 2nd toes Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first[rarediseases.info.nih.gov]

    Missing: Hyperextensible Joints
  • Dubowitz Syndrome

    Microcephaly, short stature, leg length discrepancy, hyperextensible joints, spina bifida occulta, and absence of anterior cruciate ligaments were present.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Major clinical findings are intrauterine and postnatal growth retardation, considerable microcephaly, mild mental retardation, hyperactivity, hyperextensibility of joints,[ncbi.nlm.nih.gov]

    Missing: Duplication or Triplication of Phalanges
  • Marfan Syndrome

    Potentially important abnormalities include hyperextensible joints (possible positioning implications), high arched palate (airway implications), pectus excavatum , and kyphoscoliosis[openanesthesia.org] Joint hyperextensibility is present in some, but not all, patients with Marfan syndrome.[dermaamin.com] Sternum deformity—pectus carinatum (outward displacement) or pectus excavatum (inward displacement)—is common, as are joint hyperextensibility (but usually small flexion contractures[merckmanuals.com]

    Missing: Duplication or Triplication of Phalanges Wide Space Between the First and Second Toe
  • Cutis Laxa

    Individuals with these conditions often present with cutis laxa, progeroid features, and hyperextensible joints.[ncbi.nlm.nih.gov] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br] Other clinical features include hyperelastic skin with easy bruising, varicosities, bladder diverticuli, hernias, hyperextensible joints and multiple skeletal anomalies.[cancertherapyadvisor.com]

    Missing: Duplication or Triplication of Phalanges
  • Mucopolysaccharidosis

    It is marked by shortness and hyperextension of the neck causing the head to appear as if it were resting directly on the shoulders, short trunk, long extremities with excessive[icd9data.com] Careful positioning and avoidance of hyperextension of the neck are necessary.[medicalhomeportal.org] joint mobility, kyphosis or kyphoscoliosis, pectus carinatum, the sternum extending from clavicular junction and angling downward in midsection, spinal cord compression associated[icd9data.com]

    Missing: Duplication or Triplication of Phalanges Wide Space Between the First and Second Toe
  • Atelosteogenesis Type 2

    Malformations in the skeleton like joint hyperextensions and bifid humerus (bone of the arm), clubbed feet, facial features including depressed nasal bridge, widely separated[rarediseases.org] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov]

    Missing: Duplication or Triplication of Phalanges
  • SHORT Syndrome

    The facial appearance and some of the features resemble the SHORT syndrome, the name being an acronym for Short stature, Hyperextensible joints, Ocular depression, Rieger[ncbi.nlm.nih.gov] ) joints, and a soft out-pouching in the lower abdomen called an inguinal hernia.[ghr.nlm.nih.gov] This 9-year-old Italian boy was short of stature and had partial lipodystrophy, minor facial anomalies, mild hyperextensibility of joints, ocular depression, Rieger anomaly[ncbi.nlm.nih.gov]

    Missing: Duplication or Triplication of Phalanges Wide Space Between the First and Second Toe
  • Mucopolysaccharidosis 4A

    […] atlantoaxial joint, requiring limited hyperextension of the neck all of which may complicate laryngoscopy and intubation [ 3 ].[omicsonline.org] It is marked by shortness and hyperextension of the neck causing the head to appear as if it were resting directly on the shoulders, short trunk, long extremities with excessive[icd10data.com] Patients present with severe airway obstructions, cranio-facial abnormalities, short neck, stiffening of the temporomandibular joints, anteriorly positioned larynx, unstable[omicsonline.org]

    Missing: Duplication or Triplication of Phalanges Wide Space Between the First and Second Toe
  • Autosomal Dominant Hyper-IgE Syndrome

    Nonimmunologic manifestations of HIES include a characteristic face, pathologic dentition, scoliosis, bone alterations, hyperextensible joints, and vascular abnormalities.[ncbi.nlm.nih.gov] Common findings among patients were recurrent fractures (in 57 percent of patients), hyperextensible joints (in 68 percent), and scoliosis (in 76 percent of patients 16 years[scienceopen.com] Eczema, mucocutaneous candidiasis, retention of the primary teeth, coarse facial features, osteopenia, hyperextensible joints and increased risk of malignancy are also common[medcraveonline.com]

    Missing: Duplication or Triplication of Phalanges Wide Space Between the First and Second Toe

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