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55 Possible Causes for Duplication or Triplication of Phalanges, Thick Wiry Hair, Wide Space Between the First and Second Toe

  • Craniofrontonasal Dysplasia

    wiry hair, and occasionally cleft lip and/or palate.[genedx.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] wiry hair with orbital asymmetry and strabismus. 5 The extracranial features include multiple skeletal malformations, such as sloping shoulders, dysplastic clavicles, thoracic[ncbi.nlm.nih.gov]

    Missing: Duplication or Triplication of Phalanges
  • Kleiner Holmes Syndrome

    Radiographs show broad, shortened, misshapen first metatarsals and may associate incomplete or complete duplication of proximal phalanges and duplication or triplication of[malacards.org] […] gap between first and second toes Wide space between 1st, 2nd toes Wide space between first and second toes Widely spaced 1st-2nd toes Widely spaced first and second toes[rarediseases.info.nih.gov] Radiographs showed broad, short, and misshapen first metatarsals, duplication of the proximal phalanges, and triplication of the distal phalanges on the right foot and duplication[omim.org]

    Missing: Thick Wiry Hair
  • Down Syndrome

    A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] spacing, often with a deep plantar groove between the first and second toes.[doi.org] […] fissures, Brushfield spots, small mouth, small ears, excessive skin at the nape of the neck, single transverse palmar crease, and short fifth finger with clinodactyly and wide[doi.org]

    Missing: Duplication or Triplication of Phalanges Thick Wiry Hair
  • Dubowitz Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov] […] infection infections, recurrent Predisposition to infections Susceptibility to infection [ more ] 0002719 Respiratory insufficiency Respiratory impairment 0002093 Sandal gap Gap between[rarediseases.info.nih.gov]

    Missing: Duplication or Triplication of Phalanges Thick Wiry Hair
  • Ring Chromosome 10

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov] […] weak muscle tone 0001252 Pectus excavatum Funnel chest 0000767 Renal hypoplasia/aplasia Absent/small kidney Absent/underdeveloped kidney [ more ] 0008678 Sandal gap Gap between[rarediseases.info.nih.gov]

    Missing: Duplication or Triplication of Phalanges Thick Wiry Hair
  • Atelosteogenesis Type 2

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov] Flattened vertebrae 0000926 Pulmonary hypoplasia Small lung Underdeveloped lung [ more ] 0002089 Respiratory insufficiency Respiratory impairment 0002093 Sandal gap Gap between[rarediseases.info.nih.gov]

    Missing: Duplication or Triplication of Phalanges Thick Wiry Hair
  • Polysyndactyly

    […] or triplication of phalanges Clinical features from OMIM: 234280 MalaCards organs/tissues related to Hallux Varus and Preaxial Polysyndactyly: 42 Bone Search GEO for disease[malacards.org] […] hallux varus 33 HP:0008080 6 broad hallux 33 HP:0010055 Symptoms via clinical synopsis from OMIM: 58 Skeletal Feet: hallux varus broad great toes preaxial polysyndactyly duplication[malacards.org]

    Missing: Thick Wiry Hair Wide Space Between the First and Second Toe
  • Short Stature due to Endocrine Disorder

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov] […] tissue Reduced fat tissue below the skin 0003758 Retrognathia Receding chin Receding lower jaw Weak chin Weak jaw [ more ] 0000278 Rieger anomaly 0000558 Sandal gap Gap between[rarediseases.info.nih.gov]

    Missing: Duplication or Triplication of Phalanges Thick Wiry Hair
  • Hidrotic Ectodermal Dysplasia

    What to be alert for in the history --Abnormally thick and wiry hair in infancy --Progressive alopecia with age --Progressively dystrophic nails --Palmoplantar changes --Painful[dermatologyadvisor.com] Early signs and symptoms generally begin in infancy and may include nail abnormalities and sparse scalp hair that is wiry, brittle, patchy and pale.[rarediseases.info.nih.gov] In infancy, scalp hair is wiry, brittle, patchy, and pale; progressive hair loss may lead to total alopecia by puberty.[en.wikipedia.org]

    Missing: Duplication or Triplication of Phalanges Wide Space Between the First and Second Toe
  • Seckel Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov] Wide space between first and second toes Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and second toe [ more ][rarediseases.info.nih.gov]

    Missing: Duplication or Triplication of Phalanges Thick Wiry Hair