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2,714 Possible Causes for Dysarthria, 'Eye of the Tiger' Sign on MRI, Jerk-Locked Premyoclonus Spikes

  • Hallervorden-Spatz Syndrome

    He developed dysarthria, difficulty with his gait and dystonia in his arms at the age of 28 years.[ncbi.nlm.nih.gov] Iron deposition in conjunction with destruction of the globus pallidus gives rise to the characteristic eye-of-the-tiger sign in MRI.[ncbi.nlm.nih.gov] […] of the tiger" sign.[ncbi.nlm.nih.gov]

    Missing: Jerk-Locked Premyoclonus Spikes
  • Benign Adult Familial Myoclonic Epilepsy

    88%), eye movement abnormalities (particularly in later stages supranuclear horizontal or vertical gaze saccadic palsy) (78%), limb dystonia (77%), pyramidal signs (73%), dysarthria[neuroweb.us] […] cortical spikes detected by the jerk-locked back-averaging) ( Ikeda et al., 1990 ).[academic.oup.com] spikes detected by the jerk-locked back averaging (JLA) method), and a good response to antiepileptic drugs. 2 BAFME was first reported in 1990 in the Japanese population[nature.com]

  • Neurodegeneration with Brain Iron Accumulation

    Abstract Hallervorden and Spatz first described, in a sibship of 12, five sisters with clinically increasing dysarthria and progressive dementia, whose brains showed a brown[ncbi.nlm.nih.gov] Individuals with PKAN and HARP syndrome, which is considered part of the PKAN disease spectrum, show a characteristic "eye of the tiger''sign on MRI, a central region of hyperintensity[orpha.net] A male patient presented at age 66 with change of personality: disinhibition, emotional blunting, and socially inappropriate behavior, coupled with dysarthria, dystonia, and[ncbi.nlm.nih.gov]

    Missing: Jerk-Locked Premyoclonus Spikes
  • Juvenile Paralysis Agitans of Hunt

    List of possible causes of Dysarthria or similar symptoms may include: 8 Acanthocytosis (Dysarthria) Aceruloplasminemia (Dysarthria) Achondroplasia (Dysarthria) Adrenomyeloneuropathy[familydiagnosis.com] Parkinsonismo precoce associado a lesões palidais de tipo "eye-of-the-tiger" "Eye-of-the-tiger" sign at MRI in a patient with early-onset parkinsonism Egberto Reis Barbosa[scielo.br] It is characterised by tremor, bradykinesia, dysarthria, rigidity, fixed facies and a tendency to faint. Mental functions are intact and there are no reflex changes.[whonamedit.com]

    Missing: Jerk-Locked Premyoclonus Spikes
  • Alcoholic Cerebellar Degeneration

    Dysarthria and upper limb ataxia are rare. 4 Pathophysiology Ataxia may develop during periods of abstinence.[slideplayer.com] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[neuroweb.us] Inherited periodic ataxia, dysarthria, nystagmus and vertigo.[patient.info]

    Missing: Jerk-Locked Premyoclonus Spikes
  • Senile Chorea

    Violent movements interfere with articulation muscles, as a result of developing dysarthria - speech disorder caused by disorders of articulation.[medicalformat.com] Her MRI did not show the typical “eye of the tigersign or pronounced low signal in the globus pallidus without the additional inserted bright signal that has now been well[jnnp.bmj.com] Motor symptoms: impairment related to involuntary (chorea) and voluntary movements, reduced manual dexterity, dysarthria, dysphagia, gait instability, and falls are common[neupsykey.com]

    Missing: Jerk-Locked Premyoclonus Spikes
  • Acute Alcohol Intoxication

    The first patient (female, 50 years old) had dysarthria, nystagmus and trunk ataxia on admission. Her blood alcohol level was 2.3‰.[ncbi.nlm.nih.gov] […] tend to have less tolerance than males typical 50-100 mg/dL: relaxation, sedation, prolonged reaction time,euphoria 100-200 mg/dL: impaired motor function and coordination, dysarthria[lifeinthefastlane.com] […] detected at PACU, especially neurological ones associated to alcohol intoxication, similar to inebriation, tachycardia, facial flushing, cold sweating, agitation and confusion, dysarthria[scielo.br]

    Missing: 'Eye of the Tiger' Sign on MRI Jerk-Locked Premyoclonus Spikes
  • Epilepsia Partialis Continua

    The patient improved with antiviral treatment except for very mild residual dysarthria.[ncbi.nlm.nih.gov] Jerk-locked back averaging (JLA) of magnetoencephalogram disclosed a spike preceding the jerk localized at the hand motor area, whereas JLA of electroencephalogram revealed[ncbi.nlm.nih.gov] We report an adult male who presented with disabling dysarthria due to epilepsia partialis continua (EPC) of the left half of the tongue.[ncbi.nlm.nih.gov]

    Missing: 'Eye of the Tiger' Sign on MRI
  • Mitochondrial Membrane Protein-Associated Neurodegeneration

    Lower limb spacity, dysarthria, dysphagia, dystonia, neuropsychiatric symptoms, optic atrophy, Parkinsonism and cognitive decline 1 .[radiopaedia.org] None of our pa-tients exhibited the eye of the tiger sign on T2-weighted MRI.[docslide.net] 30% of cases NBIA cases, with less than 80 cases reported to date.Clinical descriptionMPAN usually manifests during childhood (mean age: 10 years) with, gait difficulty, dysarthria[malacards.org]

    Missing: Jerk-Locked Premyoclonus Spikes
  • Subacute Cerebellar Degeneration

    Inherited periodic ataxia, dysarthria, nystagmus and vertigo.[patient.info] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[neuroweb.us] Prominent ataxic dysarthria, dysmetria of upper limbs more than lower limb, dysdiadochokinesia and intentional tremors were observed.[annalsofian.org]

    Missing: Jerk-Locked Premyoclonus Spikes

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