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12 Possible Causes for Dysarthria, Myoclonic Jerking, Onset of Disease between 25 and 40 Years of Age

  • Wilson Disease

    jerking similar to that seen in progressive myoclonic syndrome.[web.archive.org] Clinical manifestations of neurologic Wilson's disease include variable combinations of dysarthria, dystonia, tremor, and choreoathetosis.[ncbi.nlm.nih.gov] Onset is slow and begins between 11 and 25 years of age. Signs and Symptoms In about 40 to 50% of patients, the disease first affects the central nervous system (CNS).[diagnose-me.com]

  • Adult-Onset Autosomal Recessive Cerebellar Ataxia

    […] to manage her frequent myoclonic jerking.[jnnp.bmj.com] A slowly progressive cerebellar syndrome with various combinations of oculomotor disorders, dysarthria, dysmetria/kinetic tremor, and ataxic gait are key presenting features[emedicine.medscape.com] The age of onset may vary between 40 - 80 years and the mean duration of ataxia between 3 - 25 years.[neuroweb.us]

  • Benign Adult Familial Myoclonic Epilepsy

    By the jerk-locked averaging method, a positive spike time-locked to the myoclonic jerk was demonstrated in four patients before 15-20 msec of myoclonic jerk.[ci.nii.ac.jp] 88%), eye movement abnormalities (particularly in later stages supranuclear horizontal or vertical gaze saccadic palsy) (78%), limb dystonia (77%), pyramidal signs (73%), dysarthria[neuroweb.us] ., adj myoclon ic. A single myoclonic arm or leg jerk is normal when the person is falling asleep. Myoclonic jerks are severe with grand mal seizures.[medical-dictionary.thefreedictionary.com]

  • Acute Cerebellar Ataxia

    Four weeks later he developed myoclonic jerks. Electroencephalogram showed characteristic periodic complexes time-locked with myoclonus.[ncbi.nlm.nih.gov] A 2-year-old boy, with the primary difficulties of nausea and vomiting, developed a staggering gait and dysarthria 10 days after varicella vaccination.[ncbi.nlm.nih.gov] The age of onset may vary between 40 - 80 years and the mean duration of ataxia between 3 - 25 years.[neuroweb.us]

  • Alcoholic Cerebellar Degeneration

    Other clinical signs include early falling and fine myoclonic jerks of the fingers /limb and can be elicited by tapping the limb.[neuroweb.us] Dysarthria and upper limb ataxia are rare. 4 Pathophysiology Ataxia may develop during periods of abstinence.[slideplayer.com] Inherited periodic ataxia, dysarthria, nystagmus and vertigo.[patient.info]

  • Subacute Cerebellar Degeneration

    Other clinical signs include early falling and fine myoclonic jerks of the fingers /limb and can be elicited by tapping the limb.[neuroweb.us] Inherited periodic ataxia, dysarthria, nystagmus and vertigo.[patient.info] Prominent ataxic dysarthria, dysmetria of upper limbs more than lower limb, dysdiadochokinesia and intentional tremors were observed.[annalsofian.org]

  • Early-Onset Cerebellar Ataxia

    Other clinical signs include early falling and fine myoclonic jerks of the fingers /limb and can be elicited by tapping the limb.[neuroweb.us] Dysarthria and cerebellar atrophy were the most common features in our sample.[ncbi.nlm.nih.gov] This is associated with dysarthria, pyramidal signs in the limbs, normal or increased knee jerks and upper limb reflexes and in some instances sensory loss.[ncbi.nlm.nih.gov]

  • Cerebellar Ataxia with Peripheral Neuropathy Type 2

    Other clinical signs include early falling and fine myoclonic jerks of the fingers /limb and can be elicited by tapping the limb.[neuroweb.us] A slowly progressive cerebellar syndrome with various combinations of oculomotor disorders, dysarthria, dysmetria/kinetic tremor, and ataxic gait are key presenting features[emedicine.medscape.com] Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria[nhs.uk]

  • Spinocerebellar Ataxia with Rigidity and Peripheral Neuropathy

    Other clinical signs include early falling and fine myoclonic jerks of the fingers /limb and can be elicited by tapping the limb.[neuroweb.us] A slowly progressive cerebellar syndrome with various combinations of oculomotor disorders, dysarthria, dysmetria/kinetic tremor, and ataxic gait are key presenting features[emedicine.medscape.com] Subacute necrotizing encephalopathy, also called Leigh disease, is a lethal disorder of infancy marked by psychomotor delay, myoclonic jerks, paralyses of eye movements, and[britannica.com]

  • Early-Onset Spastic Ataxia - Neuropathy Syndrome

    Other clinical signs include early falling and fine myoclonic jerks of the fingers /limb and can be elicited by tapping the limb.[neuroweb.us] A slowly progressive cerebellar syndrome with various combinations of oculomotor disorders, dysarthria, dysmetria/kinetic tremor, and ataxic gait are key presenting features[emedicine.medscape.com] Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria[nhs.uk]

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