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102 Possible Causes for Dysarthria, Rapid Progression to Disability

  • Alzheimer Disease

    Our findings may reflect the presence of greater comorbidity leading to earlier death among men than among women with AD, 57 or a more rapid progression of AD in women. 58[doi.org] The clinical phenotype was remarkable for spastic dysarthria, limb spasticity, and seizures, in addition to more typical features of EOFAD.[ncbi.nlm.nih.gov] A four-generation pedigree exhibiting early-onset autosomal dominant Alzheimer disease (AD) with spastic paraplegia, dystonia, and dysarthria due to a novel 6-nucleotide insertional[ncbi.nlm.nih.gov]

  • Primary Progressive Multiple Sclerosis

    Although progression is more rapid, age-related disability milestones are identical to relapsing-onset disease.[ncbi.nlm.nih.gov] A 28-year-old woman developed progressive spastic gait and dysarthria.[ncbi.nlm.nih.gov] ., adj sclerot ic. familial centrolobar sclerosis a progressive familial form of leukoencephalopathy marked by nystagmus, ataxia, tremor, parkinsonian facies, dysarthria,[medical-dictionary.thefreedictionary.com]

  • Transient Ischemic Attack

    Rapid recognition and response is essential to reduce the risk of disability and death. 4,8,10 As the American Heart Association/American Stroke Association (AHA/ASA) points[journals.lww.com] A 69-year-old gentleman presented with a TIA episode (dysarthria, right-arm weakness, and numbness).[ncbi.nlm.nih.gov] […] associated with an estimated 9% risk of stroke within 90 days. 1 We report the case of a 72-year-old female who presented with orthostatic symptoms of facial weakness and dysarthria[ncbi.nlm.nih.gov]

  • Hallervorden-Spatz Syndrome

    Rapid progression of the disease may lead to severe disability, life-threatening state, the status dystonicus, and several critical events such as hyperpyrexia, dehydration[file.scirp.org] He developed dysarthria, difficulty with his gait and dystonia in his arms at the age of 28 years.[ncbi.nlm.nih.gov] Dysarthria, dysphagia, and dystonic-athetoid movements of the face and right fingers were marked. Magnetic resonance showed the typical "eye-of-the-tiger" sign.[ncbi.nlm.nih.gov]

  • Amyotrophic Lateral Sclerosis

    One woman with ALS received intracranial injection of adult olfactory ensheathing glia (OEG) transplantation and her disease progressed at a more rapid rate after the procedure[doi.org] […] progression are available for ALS, but patient management is largely mediated by symptomatic therapies, such as the use of muscle relaxants for spasticity and speech therapy for dysarthria[ncbi.nlm.nih.gov] An 82-year-old woman developed neck weakness and dysarthria with antibodies against acetylcholine receptor (AChR) and low-density lipoprotein receptor-related protein 4 (LRP4[ncbi.nlm.nih.gov]

  • Multiple Sclerosis

    progression of disability, more frequent relapses, and worse postrelapse recoveries.[dx.doi.org] Articulation abilities were evaluated using the articulation subtest from the Fussi assessment (dysarthria scores).[ncbi.nlm.nih.gov] Multiple Sclerosis have a higher incidence of spinal cord lesion and exhibit much more rapid development of disability than those with other forms of the disease 1 in every[themcfox.com]

  • Niemann-Pick Disease Type C

    In conclusion, our findings showed a progression in all four parameters of the disability scale, representing a continuous, unbroken progression of neurological manifestations[ncbi.nlm.nih.gov] Major clinical features included cerebellar ataxia (76%), vertical supranuclear ophthalmoplegia (VSO, 75%), dysarthria, (63%), cognitive troubles (61%), movement disorders[ncbi.nlm.nih.gov] He was subsequently diagnosed with NPC as the emerging features of dementia, ataxia, dysarthria, and vertical supranuclear ophthalmoplegia were recognized.[ncbi.nlm.nih.gov]

  • CADASIL Syndrome

    Most patients with worsening disability in this cohort had experienced a new stroke, indicating that recurrent stroke is a major determinant of disability progression in CADASIL[functionalneurology.com] She had spastic dysarthria. External ocular movements were full without nystagmus. Other cranial nerves and fundi were normal.[neurologyindia.com] […] diabetes mellitus are not common.(1) The age of onset is usually in the 40’s, with most patients presenting with a typical lacunar syndrome (pure motor and/or sensory stroke, dysarthria[eso-stroke.org]

  • Guillain-Barré Syndrome

    A number of factors, including preceding diarrhoea, older age, rapid progression, disability at nadir and specific neurophysiological parameters have been associated with[doi.org] Facial weakness, dysphasia or dysarthria may develop. In severe cases, muscle weakness may lead to respiratory failure.[patient.info] She did not have hoarseness butshe had mild dysarthria and experienced mild difficulty inswallowing.[docslide.us]

  • Chorea Gravidarum

    ; • Disability out of proportion to the movement disorder.[ahcmedia.com] As you speak to them note if there is any dysarthria.[ptpaces.wordpress.com] In addition to choreic movements, individuals with Sydenham chorea may develop muscle weakness, slurred speech (dysarthria), diminished muscle tone (hypotonia), tics, obsessions[rarediseases.org]

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