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581 Possible Causes for Dysdiadochokinesis, Motor Incoordination, Mutation in the WWOX Gene

  • Spinocerebellar Ataxia Type 12

    Mutation in the WWOX gene, D. schematic of the WWOX gene). Figure adapted from WWOX.[epilepsygenetics.net] MalaCards based summary : Spinocerebellar Ataxia 12, also known as sca12, is related to spinocerebellar ataxia 36 and aceruloplasminemia, and has symptoms including dysdiadochokinesis[malacards.org] Ataxia may cause involuntary eye movements (nystagmus), incoordination of hands, difficulty with fine motor tasks (such as eating or writing), slurring of speech and an unsteady[bcm.edu]

  • Cerebellar Disease

    WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.[genome.jp] Limb ataxia is shown by limbs that are clumsy, discoordinated, and that have difficulty with rapidly alternating movements (a phenomenon unhelpfully known as dysdiadochokinesis[medicguide.blogspot.com] Fine motor incoordination - Difficulty with handwriting, cutting food, opening jars, buttoning clothes, sewing, typing, playing an instrument or a sport.[hopkinsmedicine.org]

  • Spinocerebellar Ataxia Type 1

    Slow eye movements 0000514 Slurred speech 0001350 Staring gaze 0025401 Upgaze palsy 0025331 5%-29% of people have these symptoms Abnormality of masticatory muscle 0410011 Dysdiadochokinesis[rarediseases.info.nih.gov] Sca1(154Q/2Q) mice developed a progressive neurological disorder that resembles human SCA1, featuring motor incoordination, cognitive deficits, wasting, and premature death[ncbi.nlm.nih.gov] 29 See the list below: Clinical features Nonprogressive ataxia Nystagmus Dysarthria Psychomotor display Clumsiness Cognitive impairment Frequent falling early in disease Dysdiadochokinesis[emedicine.com]

    Missing: Mutation in the WWOX Gene
  • Autosomal Recessive Spinocerebellar Ataxia 8

    Mutation in the WWOX gene, D. schematic of the WWOX gene). Figure adapted from WWOX.[epilepsygenetics.net] […] hemisphere) Neocerebellum Connected with Pons and cortex through thalalmus Planning and initiation of movements Regulation of fine limb movements Limb ataxia: Dysmetria, Dysdiadochokinesis[slideshare.net] Ataxia may cause involuntary eye movements (nystagmus), incoordination of hands, difficulty with fine motor tasks (such as eating or writing), slurring of speech and an unsteady[bcm.edu]

  • Opsoclonus-Myoclonus Syndrome

    On examination, she had a coarse jerking tremor, ataxia, dysdiadochokinesis and a marked inability to follow movement with her eyes. Abdominal examination was normal.[nature.com] The cardinal motor features include ataxia (imbalance, incoordination), myoclonus (body jerks originating from the CNS), or opsoclonus (random, multi-directional darting eyes[frontiersin.org]

    Missing: Mutation in the WWOX Gene
  • Multiple Sclerosis

    Subsequent symptoms also include more prominent upper motor neuron signs, i.e.,. increased spasticity, increasing para- or quardriparesis.[library.med.utah.edu] Vertigo, incoordination and other cerebellar problems, depression, emotional lability, abnormalities in gait, dysarthria, fatigue and pain are also commonly seen.[library.med.utah.edu]

    Missing: Mutation in the WWOX Gene
  • Cerebellopontine Angle Syndrome
    Missing: Mutation in the WWOX Gene
  • Ataxia

    The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.[ncbi.nlm.nih.gov] Nystagmus; Vestibulo-ocular reflex (VOR) Postural and gait dysfunction Midline (Vermis; paleocerebellum)Truncal & gait ataxia Hemisphere (Neocerebellum)Limb ataxia: Dysmetria, Dysdiadochokinesis[neuromuscular.wustl.edu] Ataxia may cause involuntary eye movements (nystagmus), incoordination of hands, difficulty with fine motor tasks (such as eating or writing), slurring of speech and an unsteady[bcm.edu]

  • Spinocerebellar Ataxia Type 13

    WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.[genome.jp] The neurologic examination showed markedly slow ocular saccades, dysarthria, upper and lower limb dysmetria, dysdiadochokinesis, and wide-based ataxic gait.[jamanetwork.com] AB - The autosomal dominant spinocerebellar ataxias (SCAs) are a diverse group of neurological disorders anchored by the phenotypes of motor incoordination and cerebellar[experts.umn.edu]

  • Huntington's Disease

    Pathways to motor incoordination: the inherited ataxias. Nat. Rev. Neurosci. 5, 641–655 (2004). 35. Bellamy, T.C.[doi.org] Pathways to motor incoordination: the inherited ataxias. Nat. Rev. Neurosci. 2004; 5 :641–55. [ PubMed ] [ Google Scholar ] 39. Bellamy TC.[ncbi.nlm.nih.gov] incoordination (reviewed in ref. 38 ).[ncbi.nlm.nih.gov]

    Missing: Mutation in the WWOX Gene