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589 Possible Causes for Dysdiadochokinesis, Mutation in the WWOX Gene, Pendular Nystagmus

  • Spinocerebellar Ataxia Type 1

    Slow eye movements 0000514 Slurred speech 0001350 Staring gaze 0025401 Upgaze palsy 0025331 5%-29% of people have these symptoms Abnormality of masticatory muscle 0410011 Dysdiadochokinesis[rarediseases.info.nih.gov] 29 See the list below: Clinical features Nonprogressive ataxia Nystagmus Dysarthria Psychomotor display Clumsiness Cognitive impairment Frequent falling early in disease Dysdiadochokinesis[emedicine.com] […] dysmetria Position sense defects Spinocerebellar ataxia 36 [40] Clinical features Mean age of onset - Approximately 53 years Truncal ataxia Ataxic dysarthria Limb ataxia Dysdiadochokinesis[emedicine.com]

    Missing: Mutation in the WWOX Gene
  • Cerebellar Disease

    WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.[genome.jp] Intention Tremor Scanning speech Eyes rebound for nystagmus Rebound for the rebound phenomenon Pendulum for pendular knee jerk and hypotonia Also remember the "4 Dys" of Cerebellar[medicowesome.blogspot.com] Limb ataxia is shown by limbs that are clumsy, discoordinated, and that have difficulty with rapidly alternating movements (a phenomenon unhelpfully known as dysdiadochokinesis[medicguide.blogspot.com]

  • Friedreich Ataxia

    Friedreich ataxia is an autosomal recessive disorder resulting in progressive neurologic and cardiac sequelae. It leads to significant morbidity as well as death. While the age of onset varies from one individual to another, it usually occurs around puberty. However, there are individuals in which FA presents much[…][symptoma.com]

    Missing: Mutation in the WWOX Gene
  • Cerebellar Mass Lesion

    Nystagmus, pendular Short term memory loss Slow speech Staggering Gait Tic syndrome in a child Habit spasm Tremor Tremor,coarse Unable to tandem walk/straight line Vertigo[howmed.net] Dysdiadochokinesis is tested by asking the patient to hold up their hands and rapidly pronate and supinate repetitively.[patient.info] Clinical signs of these deficits are detected by the presence of dysmetria in finger-to-nose or heel-to-shin testing, and dysdiadochokinesis demonstrated by testing of rapid[clinicalgate.com]

    Missing: Mutation in the WWOX Gene
  • Alcoholic Cerebellar Degeneration

    Examine arms for limb ataxia (see above): rebound of outstretched arms, finger-nose test for past pointing, check for dysdiadochokinesis.[patient.info] Symptoms of cerebellar hemisphere injury include: Dysdiadochokinesis (difficulty with rapid alternating movements) Dysmetria of the hands and arm (lack of coordination or[clinicaladvisor.com] Dysdiadochokinesis is the irregular performance of rapid alternating movements. Intention tremors may be present on an attempt to touch an object.[dizziness-and-balance.com]

    Missing: Mutation in the WWOX Gene
  • Spinocerebellar Ataxia Type 12

    Mutation in the WWOX gene, D. schematic of the WWOX gene). Figure adapted from WWOX.[epilepsygenetics.net] MalaCards based summary : Spinocerebellar Ataxia 12, also known as sca12, is related to spinocerebellar ataxia 36 and aceruloplasminemia, and has symptoms including dysdiadochokinesis[malacards.org] […] size of the outer layer of the brain due to loss of brain cells 0002120 Delusions 0000746 Depressivity Depression 0000716 Dysarthria Difficulty articulating speech 0001260 Dysdiadochokinesis[rarediseases.info.nih.gov]

    Missing: Pendular Nystagmus
  • Cerebellar Neoplasm

    Clinical signs of these deficits are detected by the presence of dysmetria in finger-to-nose or heel-to-shin testing, and dysdiadochokinesis demonstrated by testing of rapid[clinicalgate.com] Dysdiadochokinesis is the irregular performance of rapid alternating movements. Intention tremors may be present on an attempt to touch an object.[dizziness-and-balance.com]

    Missing: Mutation in the WWOX Gene
  • Cerebellar Infarction

    Midbrain/Thalamic hemorrahages Movie of mixed jerk torsion and shimmering pendular (9 meg) Midbrain hemorrhages can cause very devastating nystagmus, often with twisting eye[dizziness-and-balance.com] Examine arms for limb ataxia (see above): rebound of outstretched arms, finger-nose test for past pointing, check for dysdiadochokinesis.[patient.info] In the patient whose images are shown above, there is a very rapid but small amplitude horizontal nystagmus, apparently pendular, not always present, superimposed on a constantly[dizziness-and-balance.com]

    Missing: Mutation in the WWOX Gene
  • Acute Cerebellar Ataxia

    Nystagmus, skew deviation, disconjugate saccades, and altered ocular pursuit can be present.[ajnr.org] Examine arms for limb ataxia (see above): rebound of outstretched arms, finger-nose test for past pointing, check for dysdiadochokinesis.[patient.info] […] unsteady gait, errors of extremity trajectory or placement, errors in motor sequence or rhythm and/or by dysarthria. 1 Tone is usually decreased and stretch reflexes may be “pendular[ajnr.org]

    Missing: Mutation in the WWOX Gene
  • Cerebellar Hemangioblastoma

    Clinical signs of these deficits are detected by the presence of dysmetria in finger-to-nose or heel-to-shin testing, and dysdiadochokinesis demonstrated by testing of rapid[clinicalgate.com] Dysdiadochokinesis is the irregular performance of rapid alternating movements. Intention tremors may be present on an attempt to touch an object.[dizziness-and-balance.com]

    Missing: Mutation in the WWOX Gene

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