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308 Possible Causes for Dysdiadochokinesis, Mutation in the WWOX Gene, Poor Coordination of the Lower Extremity

  • Spinocerebellar Ataxia Type 12

    Mutation in the WWOX gene, D. schematic of the WWOX gene). Figure adapted from WWOX.[epilepsygenetics.net] SCA8 SCA-8 is a slowly progressive ataxia resulting in poor coordination of limbs, especially lower extremities, and poor coordination of gait and speech.[ataxiacenter.umn.edu] MalaCards based summary : Spinocerebellar Ataxia 12, also known as sca12, is related to spinocerebellar ataxia 36 and aceruloplasminemia, and has symptoms including dysdiadochokinesis[malacards.org]

  • Friedreich Ataxia

    Friedreich ataxia (FRDA) is an autosomal recessive ataxia resulting from mutations in the frataxin gene (FXN). Such mutations, usually expanded guanine-adenine-adenine (GAA) repeats, give rise to decreased levels of frataxin protein in both affected and unaffected tissues. The goal was to understand the[…][ncbi.nlm.nih.gov]

    Missing: Mutation in the WWOX Gene
  • Cerebellar Disease

    WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.[genome.jp] Limb ataxia is shown by limbs that are clumsy, discoordinated, and that have difficulty with rapidly alternating movements (a phenomenon unhelpfully known as dysdiadochokinesis[medicguide.blogspot.com] Dysdiadochokinesis The patient will be unable to perform rapid alternating movements. Arrhythmokinesis The patient will be unable to tap out a simple tune on your desk.[derangedphysiology.com]

  • Autosomal Recessive Spinocerebellar Ataxia 8

    Mutation in the WWOX gene, D. schematic of the WWOX gene). Figure adapted from WWOX.[epilepsygenetics.net] […] hemisphere) Neocerebellum Connected with Pons and cortex through thalalmus Planning and initiation of movements Regulation of fine limb movements Limb ataxia: Dysmetria, Dysdiadochokinesis[slideshare.net] SCA8 SCA-8 is a slowly progressive ataxia resulting in poor coordination of limbs, especially lower extremities, and poor coordination of gait and speech.[ataxiacenter.umn.edu]

  • Spinocerebellar Ataxia Type 1

    SCA8 SCA-8 is a slowly progressive ataxia resulting in poor coordination of limbs, especially lower extremities, and poor coordination of gait and speech.[ataxiacenter.umn.edu] Slow eye movements 0000514 Slurred speech 0001350 Staring gaze 0025401 Upgaze palsy 0025331 5%-29% of people have these symptoms Abnormality of masticatory muscle 0410011 Dysdiadochokinesis[rarediseases.info.nih.gov] 29 See the list below: Clinical features Nonprogressive ataxia Nystagmus Dysarthria Psychomotor display Clumsiness Cognitive impairment Frequent falling early in disease Dysdiadochokinesis[emedicine.com]

    Missing: Mutation in the WWOX Gene
  • Spinocerebellar Ataxia Type 13

    WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.[genome.jp] SCA8 SCA-8 is a slowly progressive ataxia resulting in poor coordination of limbs, especially lower extremities, and poor coordination of gait and speech.[ataxiacenter.umn.edu] The neurologic examination showed markedly slow ocular saccades, dysarthria, upper and lower limb dysmetria, dysdiadochokinesis, and wide-based ataxic gait.[jamanetwork.com]

  • Autosomal Recessive Spinocerebellar Ataxia

    WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.[genome.jp] People with this type of ataxia share many characteristic symptoms including: frequent falls due to poor balance imprecise hand coordination postural or kinetic tremor of[en.wikipedia.org] 29 See the list below: Clinical features Nonprogressive ataxia Nystagmus Dysarthria Psychomotor display Clumsiness Cognitive impairment Frequent falling early in disease Dysdiadochokinesis[emedicine.medscape.com]

  • Autosomal Recessive Spinocerebellar Ataxia 18

    MalaCards based summary : Spinocerebellar Ataxia, Autosomal Recessive 18, is also known as scar18, and has symptoms including cerebellar ataxia, dysdiadochokinesis and ataxia[malacards.org] SCA8 SCA-8 is a slowly progressive ataxia resulting in poor coordination of limbs, especially lower extremities, and poor coordination of gait and speech.[ataxiacenter.umn.edu] […] spinocerebellar ataxia type 18, is related to autosomal dominant cerebellar ataxia and spinocerebellar ataxia, autosomal recessive 18, and has symptoms including tremor and dysdiadochokinesis[malacards.org]

    Missing: Mutation in the WWOX Gene
  • Hereditary Cerebellar Degeneration

    Coordination: Marked ataxia finger-nose-finger test Bilateral dysdiadochokinesis Lower extremity ataxia heel-knee-shin test and foot tapping Trunkal ataxia and wide-based[collections.lib.utah.edu] Symptoms of cerebellar hemisphere injury include: Dysdiadochokinesis (difficulty with rapid alternating movements) Dysmetria of the hands and arm (lack of coordination or[clinicaladvisor.com] Dysdiadochokinesis is the irregular performance of rapid alternating movements. Intention tremors may be present on an attempt to touch an object.[dizziness-and-balance.com]

    Missing: Mutation in the WWOX Gene
  • Alcoholic Cerebellar Degeneration

    Examine arms for limb ataxia (see above): rebound of outstretched arms, finger-nose test for past pointing, check for dysdiadochokinesis.[patient.info] Symptoms of cerebellar hemisphere injury include: Dysdiadochokinesis (difficulty with rapid alternating movements) Dysmetria of the hands and arm (lack of coordination or[clinicaladvisor.com] Dysdiadochokinesis is the irregular performance of rapid alternating movements. Intention tremors may be present on an attempt to touch an object.[dizziness-and-balance.com]

    Missing: Mutation in the WWOX Gene