Create issue ticket

498 Possible Causes for Dysdiadochokinesis, Mutation in the WWOX Gene, Unstable Gait

  • Spinocerebellar Ataxia Type 12

    Mutation in the WWOX gene, D. schematic of the WWOX gene). Figure adapted from WWOX.[epilepsygenetics.net] MalaCards based summary : Spinocerebellar Ataxia 12, also known as sca12, is related to spinocerebellar ataxia 36 and aceruloplasminemia, and has symptoms including dysdiadochokinesis[malacards.org] During the early onset of symptoms patients describe a loss of limb coordination, unstable gait, slurred speech and loss of control in handwriting.[themedicalbiochemistrypage.org]

  • Autosomal Recessive Spinocerebellar Ataxia

    WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.[genome.jp] 29 See the list below: Clinical features Nonprogressive ataxia Nystagmus Dysarthria Psychomotor display Clumsiness Cognitive impairment Frequent falling early in disease Dysdiadochokinesis[emedicine.medscape.com] His gait became progressively unstable from childhood, and started to interfere with his daily activities after the age of 45.[jmg.bmj.com]

  • Autosomal Recessive Spinocerebellar Ataxia Type 17

    29 See the list below: Clinical features Nonprogressive ataxia Nystagmus Dysarthria Psychomotor display Clumsiness Cognitive impairment Frequent falling early in disease Dysdiadochokinesis[emedicine.medscape.com] Gait ataxia is characterized by unstable walk and standing, which slowly progresses with the appearance of some of the other symptoms, such as abnormal hand movements, involuntary[encyclopedia.com] This deficit is most apparent in the execution of rapidly alternating movements, referred as dysdiadochokinesis by Babinski.[jpgmonline.com]

    Missing: Mutation in the WWOX Gene
  • Spinocerebellar Ataxia Type 1

    Slow eye movements 0000514 Slurred speech 0001350 Staring gaze 0025401 Upgaze palsy 0025331 5%-29% of people have these symptoms Abnormality of masticatory muscle 0410011 Dysdiadochokinesis[rarediseases.info.nih.gov] Patients with SCA1 experience progressive loss of motor coordination and function, unstable gait, and dysarthric speech [1].[neurowiki2014.wikidot.com] 29 See the list below: Clinical features Nonprogressive ataxia Nystagmus Dysarthria Psychomotor display Clumsiness Cognitive impairment Frequent falling early in disease Dysdiadochokinesis[emedicine.com]

    Missing: Mutation in the WWOX Gene
  • Autosomal Recessive Spinocerebellar Ataxia 8

    Mutation in the WWOX gene, D. schematic of the WWOX gene). Figure adapted from WWOX.[epilepsygenetics.net] […] hemisphere) Neocerebellum Connected with Pons and cortex through thalalmus Planning and initiation of movements Regulation of fine limb movements Limb ataxia: Dysmetria, Dysdiadochokinesis[slideshare.net] His gait became progressively unstable from childhood, and started to interfere with his daily activities after the age of 45.[jmg.bmj.com]

  • Autosomal Recessive Spastic Ataxia with Leukoencephalopathy

    Koenig, The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation. Brain, 2014. 137(Pt 2): p. 411-9.[hih-tuebingen.de] Leukoencephalopathy Urinary urgency Spastic dysarthria Spastic ataxia Mild hearing impairment Ranula Scoliosis Retinal degeneration Progressive visual loss Inability to walk Dysdiadochokinesis[mendelian.co] Clinical features include ataxia and unstable gait; more variable abnormalities may include visual field defects, headaches, and learning disabilities (summary by Depienne[mendelian.co]

  • Ataxia

    The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.[ncbi.nlm.nih.gov] Nystagmus; Vestibulo-ocular reflex (VOR) Postural and gait dysfunction Midline (Vermis; paleocerebellum)Truncal & gait ataxia Hemisphere (Neocerebellum)Limb ataxia: Dysmetria, Dysdiadochokinesis[neuromuscular.wustl.edu] […] and truncal ataxia was only revealed by unstable tandem gait.[ncbi.nlm.nih.gov]

  • Friedreich Ataxia

    Since his first decade of life, he showed a progressive unstable gait.[scielo.br]

    Missing: Mutation in the WWOX Gene
  • Acute Disseminated Encephalomyelitis

    This is a negative Romberg's test, or more accurately, it denotes the individual's inability to carry out the test, because the individual feels unstable even with open eyes[en.wikipedia.org] . [ citation needed ] Dysfunction of the spinocerebellum ( vermis and associated areas near the midline) presents itself with a wide-based "drunken sailor" gait (called truncal[en.wikipedia.org]

    Missing: Mutation in the WWOX Gene
  • Infantile Neuroaxonal Dystrophy

    […] development Poor language development Speech and language delay Speech and language difficulties Speech delay [ more ] 0000750 Dysarthria Difficulty articulating speech 0001260 Dysdiadochokinesis[rarediseases.info.nih.gov]

    Missing: Mutation in the WWOX Gene