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22 Possible Causes for Dysmorphic Face, Syndactyly, Wide Space Between the First and Second Toe

  • Russell-Silver Syndrome

    Syndactyly (fusion) of toes. Sprengel's neck deformity - unilateral shortening and webbing to trunk. X-ray abnormalities include: Delayed bone age.[patient.info] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] […] and further dysmorphisms.[ncbi.nlm.nih.gov]

  • Dubowitz Syndrome

    An autosomal recessive disorder characterized by intrauterine growth retardation, postnatal retardation, microcephaly, sparse hair, toe syndactyly, and characteristic facial[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Developmental Delay : behind schedule in reaching milestones of early childhood development Dysmorphic Face : this refers to minor facial anomalies that occur fairly frequently[ric.edu]

  • Craniofrontonasal Dysplasia

    Hand polydactyly Hemihypotrophy of lower limb Preaxial foot polydactyly Sandal gap Toe syndactyly Abnormality of prenatal development or birth Thickened nuchal skin fold[familydiagnosis.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Head radiographs showed macrocephaly and brachycephaly with dysmorphic face. Rest infantogram was normal.[ruralneuropractice.com]

  • Seckel Syndrome

    Patient also had spina bifida, syndactyly, undescended testis and growth retardation.[joacp.org] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] face (bird-like), and mild to severe intellectual disability.[orpha.net]

  • Kleiner Holmes Syndrome

    Syndactyly Cenani Lenz type 0 *Syndactyly.[reference.md] […] gap between first and second toes Wide space between 1st, 2nd toes Wide space between first and second toes Widely spaced 1st-2nd toes Widely spaced first and second toes[rarediseases.info.nih.gov] Mental Retardation, Microcephaly, Epilepsy, and Coarse Face Mental Retardation, Microcephaly, Growth Retardation, Joint Contractures, and Facial Dysmorphism Mental Retardation[rgd.mcw.edu]

  • Atelosteogenesis Type 2

    Syndactyly, Malik-Percin type Syndactyly of toes, telecanthus, ano- and renal malformations (STAR) syndrome Syndactyly type Lueken Oculodentodigital dysplasia Syndactyly[emedicine.medscape.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] , and mental retardation, see genitopatellar syndrome absent thumbs, dislocated joints, long face with narrow palpebral fissures, long slender nose, arched palate, see RAPADILINO[mygenomics.com]

  • Ring Chromosome 10

    The patient was referred to our Unit because of persistent thrombocytopenia and syndactyly, pes planus and a bilateral Babinski sign.[omicsonline.org] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] face, upward slanting palpebral fissures, broad nose, narrow nares, large lips, short neck, widely spaced nipples, puffy hand and feet, dark pigmented naevi, caf -au-lait[chr7.org]

  • Genee-Wiedemann Syndrome

    Postaxial limb deficiency, syndactyly and abnormal ulna/radius are noted. Intelligence is usually normal.[jomfp.in] He had a wide space between the first and second toe of his feet and subungual fibroma on the second and third toe of the right foot and on the third toe of the left foot.[jmg.bmj.com] First-trimester diagnosis of PRS has been reported after transvaginal evaluation identified the typical facial dysmorphisms [ 14, 15 ].[radiologykey.com]

  • Familial Congenital Nasolacrimal Duct Obstruction

    For example, in Apert syndrome, syndactyly of the hands and feet frequently occurs.[entokey.com] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] She had psychomotor retardation (IQ of 45), chronic constipation, and dysmorphic facial features, including square face, high forehead, hypertelorism, epicanthal folds, broad[genome.jp]

  • Kenny-Caffey Syndrome Type 1

    In the form of sclerosteosis (Truswell–Hansen disease) the patients are tall and fat with syndactyly and nail dysplasia. The hyperostosis is classically endosteal.[elsevier.es] space between the first and second toes.[medcraveonline.com] The association of severe short stature, dysmorphic face, teeth abnormalities and bone dysplasia must guide us to suggest the diagnosis especially in the Middle Eastern and[abstracts.eurospe.org]

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