Create issue ticket

405 Possible Causes for Dyspnea, Erythrocytosis, Hepatomegaly

  • Myeloproliferative Disease

    Splenomegaly, hepatomegaly as well as fatigue, malaise or weight loss may appear in advanced stages.[orpha.net] .  35 y/o previously healthy man  9 month history of tachycardia and dyspnea on exertion  Dec. 2011, dyspnea becomes more severe  Hospitalized in Miami when found to have[slideshare.net] These data suggest that erythrocytosis and granulocytosis in JAK2(V617F) mice are the net result of a complex interplay between cell intrinsic and extrinsic factors.[ncbi.nlm.nih.gov]

  • Post-Polycythemia Vera Myelofibrosis

    Presence of diabetes or another neoplasia was associated with higher ROS levels (p 0.05), splenomegaly, hepatomegaly, and peripheral blasts with lower HoloTC levels (p 0.005[ncbi.nlm.nih.gov] Grade 3 AEs included anemia (n 3), neutrophil decrease (n 2), amylase increase (n 2), lipase increase (n 2), diarrhea (n 2), colitis (n 1), dyspnea (n 1), pneumonia (n 1),[hematologytimes.com] We describe how treatment with a JAK1/2 inhibitor, ruxolitinib, led to the rapid amelioration of marrow fibrosis, erythrocytosis and thrombocytopenia in a 77-year-old man[ncbi.nlm.nih.gov]

  • Essential Thrombocythemia

    PHYSICAL EXAMINATION • Unremarkable • 40-50% present with splenomegaly • 20% present with hepatomegaly 12.[slideshare.net] A 52-year-old African American male with ET presented with chest pain, shortness of breath, and dyspnea on exertion.[ncbi.nlm.nih.gov] […] at diagnosis and for patients who subsequently develop thrombocytosis, leukocytosis, or erythrocytosis during follow-up, even for CML patients in complete cytogenetic response[ncbi.nlm.nih.gov]

  • Chronic Obstructive Pulmonary Disease

    Affected infants may present in the newborn period with cholestatic jaundice, sometimes with acholic stools (pale or clay-coloured) and hepatomegaly.[doi.org] MEASUREMENT OF DYSPNEA IN COPD Section: The two purposes of measuring dyspnea are: to differentiate between patients who have less dyspnea and those who have more dyspnea[dx.doi.org] […] oxygen therapy (LTOT) In the first Denver studies of ambulatory oxygen, patients with chronic stable hypoxemia experienced remarkable reductions in pulmonary hypertension and erythrocytosis[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    The patient, a 62-year-old female, having had primary myelofibrosis for 13 years and a splenectomy 4 years before, was admitted because of high fever, hepatomegaly, thrombocythemia[ncbi.nlm.nih.gov] Dyspnea, tachycardia and dizziness are experienced in case of severe anemia.[symptoma.com] The laboratory findings showed leuko-and erythrocytosis, increased levels of urea-BUN (32 mmol/l) and creatinine (766 mmol/l) as well as uric acid (920 mmol/l).[ncbi.nlm.nih.gov]

  • Thalassemia

    Figure 1 Probability of OS by age and hepatomegaly. Figure 2 Probability of DFS by age and hepatomegaly.[doi.org] He presented with chest discomfort and progressive dyspnea. Early echocardiogram showed mild pericardial effusion.[ncbi.nlm.nih.gov] Following extensive cardiological and neurological investigation, it was felt that significant erythrocytosis was the most likely cause.[ncbi.nlm.nih.gov]

  • Eisenmenger Syndrome

    Right heart failure (with hepatomegaly, jugular venous distention and peripheral edema, is a very late complication).[orpha.net] […] elevated in ES patients and fell significantly with sildenafil therapy that was associated with improved exercise tolerance, implying thereby a role of J receptors in producing dyspnea[ncbi.nlm.nih.gov] When bunazosin was stopped, the erythrocytosis increased, but when it was resumed, the erythrocytosis and general fatigue diminished.[ncbi.nlm.nih.gov]

  • Polycythemia Vera

    […] neurological symptoms : dizziness, headache, visual disturbances, tinnitus Hypertension Splenomegaly : associated with early satiety and abdominal discomfort; less commonly hepatomegaly[amboss.com] Three patients experienced serious AEs (7.7%), with 1 considered related to momelotinib (dyspnea). Peripheral neuropathy occurred in 7 (17.9%) patients (4 PV, 3 ET).[ncbi.nlm.nih.gov] Unexpectedly, the symptom of erythrocytosis disappeared after the surgery.[ncbi.nlm.nih.gov]

  • Hepatitis

    Findings include: hepatomegaly 15.5 cm at the midclavicular line 4 possible decreased attenuation around the portal system and at the hepatic hilum (periportal edema) possible[radiopaedia.org] When we see erythrocytosis, we should suspect the co-existence of sleep apnea syndrome.[doi.org] […] and vomiting Dehydration with drying of mucous membranes Telangiectasis (spider angiomata) and esophageal varices Jaundice Ascites Utricarial rashes Portal Hypertension Hepatomegaly[symptoma.com]

  • Ayerza Syndrome

    In the cardiovascular examination there was jugular venous distension, hepatomegaly, hepatojugular reflux, ascites and oedema of lower limbs.[err.ersjournals.com] Among those reported are angina, hyperactive precordium, paroxysmal nocturnal dyspnea, hemoptysis, raised jugular venous pressure, abnormal heart sounds, and edema.[symptoma.com] Chronic relative polycythemia or erythrocytosis has been variously called Gaisbock syndrome, stress erythrocytosis, benign polycythemia or erythrocytosis, benign erythrocytosis[enotes.tripod.com]

Similar symptoms