Dyspnea & Erythrocytosis & Hepatomegaly: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Dyspnea, Erythrocytosis, Hepatomegaly,

Negated

None

Unsure

None

Possible Causes

Myeloproliferative Disease

 35 y/o previously healthy man  9 month history of tachycardia and dyspnea on exertion  Dec. 2011, dyspnea becomes more severe  Hospitalized in Miami when found to have [slideshare.net]

Splenomegaly, hepatomegaly as well as fatigue, malaise or weight loss may appear in advanced stages. [orpha.net]

These data suggest that erythrocytosis and granulocytosis in JAK2(V617F) mice are the net result of a complex interplay between cell intrinsic and extrinsic factors. [ncbi.nlm.nih.gov]

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Post-Polycythemia Vera Myelofibrosis

Grade 3 AEs included anemia (n 3), neutrophil decrease (n 2), amylase increase (n 2), lipase increase (n 2), diarrhea (n 2), colitis (n 1), dyspnea (n 1), pneumonia (n 1), [hematologytimes.com]

Presence of diabetes or another neoplasia was associated with higher ROS levels (p 0.05), splenomegaly, hepatomegaly, and peripheral blasts with lower HoloTC levels (p 0.005 [ncbi.nlm.nih.gov]

We describe how treatment with a JAK1/2 inhibitor, ruxolitinib, led to the rapid amelioration of marrow fibrosis, erythrocytosis and thrombocytopenia in a 77-year-old man [ncbi.nlm.nih.gov]

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Essential Thrombocythemia

A 52-year-old African American male with ET presented with chest pain, shortness of breath, and dyspnea on exertion. [ncbi.nlm.nih.gov]

PHYSICAL EXAMINATION • Unremarkable • 40-50% present with splenomegaly • 20% present with hepatomegaly 12. [slideshare.net]

[…] at diagnosis and for patients who subsequently develop thrombocytosis, leukocytosis, or erythrocytosis during follow-up, even for CML patients in complete cytogenetic response [ncbi.nlm.nih.gov]

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Chronic Obstructive Pulmonary Disease

MEASUREMENT OF DYSPNEA IN COPD Section: The two purposes of measuring dyspnea are: to differentiate between patients who have less dyspnea and those who have more dyspnea [dx.doi.org]

Affected infants may present in the newborn period with cholestatic jaundice, sometimes with acholic stools (pale or clay-coloured) and hepatomegaly. [doi.org]

[…] oxygen therapy (LTOT) In the first Denver studies of ambulatory oxygen, patients with chronic stable hypoxemia experienced remarkable reductions in pulmonary hypertension and erythrocytosis [ncbi.nlm.nih.gov]

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Cor Pulmonale

We report the case of a 40-year-old woman who died after 3 days of progressive dyspnea, cough, and pulmonary hypertension. [ncbi.nlm.nih.gov]

Findings include peripheral edema, neck vein distention, hepatomegaly, and a parasternal lift. Diagnosis is clinical and by echocardiography. [merckmanuals.com]

Association between activation of rennin-angiotensin system and secondary erythrocytosis in patients with chronic obstructive pulmonary disease. [ncbi.nlm.nih.gov]

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Primary Myelofibrosis

Dyspnea, tachycardia and dizziness are experienced in case of severe anemia. [symptoma.com]

The patient, a 62-year-old female, having had primary myelofibrosis for 13 years and a splenectomy 4 years before, was admitted because of high fever, hepatomegaly, thrombocythemia [ncbi.nlm.nih.gov]

The laboratory findings showed leuko-and erythrocytosis, increased levels of urea-BUN (32 mmol/l) and creatinine (766 mmol/l) as well as uric acid (920 mmol/l). [ncbi.nlm.nih.gov]

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Familial Myelofibrosis

[…] ferritin Falls Eosinophilia Neutrophilia Joint swelling Juvenile rheumatoid arthritis Elevated C-reactive protein level Thickened calvaria Pericardial effusion Myelodysplasia Dyspnea [mendelian.co]

In case of hepatomegaly, the liver extends to more than 3 cm below the right costal margin of the newborn. [symptoma.com]

They include hereditary thrombocytosis ( THPO, MPL, JAK2 genes), hereditary erythrocytosis ( EPOR, VHL, EGLN1 and EPAS1 genes) and hereditary neutrophilia ( gene). [atlasgeneticsoncology.org]

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Eisenmenger Syndrome

[…] elevated in ES patients and fell significantly with sildenafil therapy that was associated with improved exercise tolerance, implying thereby a role of J receptors in producing dyspnea [ncbi.nlm.nih.gov]

Right heart failure (with hepatomegaly, jugular venous distention and peripheral edema, is a very late complication). [orpha.net]

When bunazosin was stopped, the erythrocytosis increased, but when it was resumed, the erythrocytosis and general fatigue diminished. [ncbi.nlm.nih.gov]

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Ayerza Syndrome

Among those reported are angina, hyperactive precordium, paroxysmal nocturnal dyspnea, hemoptysis, raised jugular venous pressure, abnormal heart sounds, and edema. [symptoma.com]

In the cardiovascular examination there was jugular venous distension, hepatomegaly, hepatojugular reflux, ascites and oedema of lower limbs. [err.ersjournals.com]

Chronic relative polycythemia or erythrocytosis has been variously called Gaisbock syndrome, stress erythrocytosis, benign polycythemia or erythrocytosis, benign erythrocytosis [enotes.tripod.com]

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Thalassemia

He presented with chest discomfort and progressive dyspnea. Early echocardiogram showed mild pericardial effusion. [ncbi.nlm.nih.gov]

Figure 1 Probability of OS by age and hepatomegaly. Figure 2 Probability of DFS by age and hepatomegaly. [doi.org]

Following extensive cardiological and neurological investigation, it was felt that significant erythrocytosis was the most likely cause. [ncbi.nlm.nih.gov]

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Polycythemia Vera

Three patients experienced serious AEs (7.7%), with 1 considered related to momelotinib (dyspnea). Peripheral neuropathy occurred in 7 (17.9%) patients (4 PV, 3 ET). [ncbi.nlm.nih.gov]

[…] neurological symptoms : dizziness, headache, visual disturbances, tinnitus Hypertension Splenomegaly : associated with early satiety and abdominal discomfort; less commonly hepatomegaly [amboss.com]

Unexpectedly, the symptom of erythrocytosis disappeared after the surgery. [ncbi.nlm.nih.gov]

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Hepatitis

Findings include: hepatomegaly 15.5 cm at the midclavicular line 4 possible decreased attenuation around the portal system and at the hepatic hilum (periportal edema) possible [radiopaedia.org]

When we see erythrocytosis, we should suspect the co-existence of sleep apnea syndrome. [doi.org]

[…] and vomiting Dehydration with drying of mucous membranes Telangiectasis (spider angiomata) and esophageal varices Jaundice Ascites Utricarial rashes Portal Hypertension Hepatomegaly [symptoma.com]

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Budd-Chiari Syndrome

Dyspnea was found in one patient due to pleural effusion and this symptom disappeared after effective drainage. [nature.com]

A 10-month-old boy presented with ascites, right pleural effusion, and hepatomegaly after consumption of herbal drinks for 3 months. [ncbi.nlm.nih.gov]

Polycythaemia vera (PV) is a clonal disorder of bone marrow stem cells characterised by erythrocytosis. [ncbi.nlm.nih.gov]

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Pulmonary Arterial Hypertension

A 64-year-old woman with multiple sclerosis presented with dyspnea. [ncbi.nlm.nih.gov]

Jugular venous distension and hepatomegaly occur with heart failure, sometimes causing a pulsatile liver later in the disease state. [clinicaladvisor.com]

One way the body compensates is to increase the ability of the blood to carry oxygen by increasing the number of red blood cells, a condition called secondary erythrocytosis [heart.org]

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Systemic Amyloidosis

A patient who presented with dyspnea and suspected interstitial pulmonary fibrosis suffered a fatal pulmonary haemorrhage with no feasible cause for bleeding. [ncbi.nlm.nih.gov]

Examination and tests in this patient also revealed anemia, hepatomegaly, infiltrative cardiomyopathy, polyneuropathy and immunoglobulin l deposition, favoring a diagnosis [ncbi.nlm.nih.gov]

Xianrui Zhang and Meiyun Fang, TEMPI Syndrome: Erythrocytosis in Plasma Cell Dyscrasia, Clinical Lymphoma Myeloma and Leukemia, 10.1016/j.clml.2018.07.284, 18, 11, (724-730 [doi.org]

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Autoimmune Hemolytic Anemia

In 2013, he complained of dyspnea. Chest computed tomography showed postoperative recurrence of invasive thymoma. Several chemotherapies were administered. [ncbi.nlm.nih.gov]

The most common clinical signs are lymphoid expansion with lymphadenopathy, splenomegaly, and hepatomegaly; immune disease with different types of cytopenia, i… Publisher [unboundmedicine.com]

While hemolysis can be a lifelong asymptomatic condition, it most often presents as anemia when erythrocytosis cannot match the pace of red cell destruction. [aafp.org]

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Acute Myeloid Leukemia

Typical symptoms are spongy and bleeding gums, anemia, fatigue, fever, dyspnea, moderate splenomegaly, joint and bone pain, and repeated infections. [medical-dictionary.thefreedictionary.com]

Multivariate analysis showed that grades 1 or 2 GVHD (P .008) and no hepatomegaly at diagnosis (P .014) were associated with improved relapse-free survival (RFS). [ncbi.nlm.nih.gov]

[…] had a history of erythropoietin therapy, known mostly in retrospect, thereby calling the diagnosis of AEL into question.36 Prior chemotherapy also can result in a rebound erythrocytosis [archivesofpathology.org]

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Precursor-Cell Lymphoblastic Leukemia

CASE REPORT A 20-year-old man began to experience cough, chest pain, and mild exertional dyspnea. [ncbi.nlm.nih.gov]

Magnetic resonance imaging of the liver with intravenous contrast enhancement done at our hospital revealed hepatomegaly. [jmedicalcasereports.biomedcentral.com]

KEYWORDS: Acute lymphoblastic leukemia; IgH-EPOR; Secondary erythrocytosis [ncbi.nlm.nih.gov]

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Sickle Cell Anemia

He presented with progressive severe dyspnea on exertion and lower extremity edema. [ncbi.nlm.nih.gov]

Additional autopsy findings included cardiomegaly with a heart weight of 450 gm (312 78), right atrial and right ventricular chamber dilatation, and hepatomegaly with a liver [ncbi.nlm.nih.gov]

A two -globin gene deletion produces hypochromia and microcytosis with a normal or mildly decreased Hb concentration and, frequently, an erythrocytosis. [web.archive.org]

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Chronic Myeloid Leukemia

Patients presenting with symptoms due to the failure of other cell lines often appear with symptomatic anemia (fatigue, dyspnea on exertion, and/or weakness) or petechiae [cancertherapyadvisor.com]

Hepatomegaly also occurs, although less commonly than splenomegaly. Hepatomegaly is usually part of the extramedullary hematopoiesis occurring in the spleen. [emedicine.medscape.com]

” 14 because such cases have now been identified to display either exon 14 or exon 12 JAK2 mutations. 11, 15 Some cases of idiopathic erythrocytosis remain molecularly undefined [doi.org]

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Hemolytic Anemia

While he was being investigated for clinical and laboratory signs mimicking hemolytic anemia, he developed cough and dyspnea. [ncbi.nlm.nih.gov]

Following this, a physical examination may reveal hepatomegaly or tenderness in the abdominal region. [symptoma.com]

Intrinsic hemolytic anemias are often inherited, such as sickle cell anemia, thalassemia, or erythrocytosis. [stanfordchildrens.org]

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Familial Polycythemia

Clinically there is dyspnea. relative polycythemia apparent polycythemia resulting from loss of plasma and the hemoconcentration that follows. [medical-dictionary.thefreedictionary.com]

PFCP is characterized by the absence of splenomegaly, hepatomegaly, and lack of all secondary causes of erythrocytosis such as pulmonary, renal, or cardiac disorders. [jahjournal.org]

In some cases, the cause of erythrocytosis is unknown. Familial erythrocytosis can have different inheritance patterns depending on the gene involved. [ghr.nlm.nih.gov]

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Anemia

Acute anemia presents with symptoms owing to acute blood loss; chronic anemia may present with worsening fatigue, dyspnea, lightheadedness, or chest pain. [ncbi.nlm.nih.gov]

[…] cycles Absent or delayed menstruation (amenorrhea) Sore or swollen tongue (glossitis) Jaundice, or yellowing of skin, eyes, and mouth Enlarged spleen or liver (splenomegaly, hepatomegaly [chop.edu]

VEGF, also increases the EPO concentrations in a dose-dependent manner.71 Likewise, transgenic mice carrying both human renin and human angiotensinogen have persistent erythrocytosis [revespcardiol.org]

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High Output Heart Failure

After the procedure, dyspnea was improved and procedure related complication was not seen. [ncbi.nlm.nih.gov]

On the third day of life, she developed cardiac failure with gallop rhythm, hepatomegaly and a murmur in the anterior fontanel; an echocardiogram confirmed clinic aggravation [ncbi.nlm.nih.gov]

VEGF, also increases the EPO concentrations in a dose-dependent manner. 71 Likewise, transgenic mice carrying both human renin and human angiotensinogen have persistent erythrocytosis [revespcardiol.org]

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Recurrent Pulmonary Embolism

A 45-year-old woman with a history of recurrent pulmonary embolism was admitted to the emergency clinic with dyspnea, wheezing and tachypnea. [ncbi.nlm.nih.gov]

VOD is primarily a clinical diagnosis characterized by hepatomegaly or pain in the right upper quadrant, jaundice, ascites, and unexplained weight gain. [emedicine.medscape.com]

She had a history of recurrent pulmonary embolism and unexplained secondary erythrocytosis. [ncbi.nlm.nih.gov]

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Paroxysmal Cold Hemoglobinuria

These symptoms may include fatigue, difficulty breathing upon exertion (dyspnea) and abnormal or extreme paleness of the skin (pallor). [rarediseases.org]

Signs Splenomegaly Hepatomegaly Transient Jaundice Pale fingers, toes, and tip of nose VI. [fpnotebook.com]

Dysuria andor urethralvaginal discharge Ear pain Ectopic pregnancy ICD9CM ICD9CM Endocarditis infective Best test Envenomation marine Eosinophilic dermatoses Epiglottitis Erythrocytosis [books.google.com]

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Polycythemia

She denied dyspnea, wheezing, snoring, witnessed apneas during sleep, aquagenic pruritus (itching after contact with warm water), or erythromelalgia (painful erythema of the [jamanetwork.com]

Physical findings include plethora, splenomegaly, and, in 25% of cases, hepatomegaly as well as those associated with the complications. [annals.org]

ERYTHROCYTOSIS AND POLYCYTHEMIA VERA 1. In patients with erythrocytosis, which of the following is not characteristic of polycythemia vera? [mdedge.com]

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Liver Cirrhosis

We report on the case of a 59-year-old woman with severe dyspnea due to a large chylothorax. She was known to have liver cirrhosis but no ascites. [ncbi.nlm.nih.gov]

Cardinal symptoms include fasting hypoglycemia, lactic acidosis and hepatomegaly as well as neutropenia. [ncbi.nlm.nih.gov]

In addition, liver cancers can produce and release a number of substances, including ones that cause an increased in red blood cell count (erythrocytosis), low blood sugar [rxlist.com]

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POEMS Syndrome

Seven months later, the patient showed symptoms of cough, dyspnea, along with rough skin, pigmentation and drooping of both feet. [ncbi.nlm.nih.gov]

Hepatomegaly was significantly reduced after the completion of BorCyDex. [ncbi.nlm.nih.gov]

Other important characteristics of POEMS include papilledema, extravascular volume overload, sclerotic bone lesions, and thrombocytosis/erythrocytosis (PEST). [ncbi.nlm.nih.gov]

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Hypoxia

The patient described his dyspnea as exertional progressing over 1 week to rest dyspnea. He was prescribed antiretroviral therapy but was noncompliant. [ncbi.nlm.nih.gov]

Last Update: 2017-04-26 Usage Frequency: 3 Quality: Reference: Wikipedia Swedish Laktacidos (i frånvaro av hypoxemi), ibland fatal, vanligen förknippad med svår hepatomegali [mymemory.translated.net]

These findings suggest that erythrocytosis was caused by renal ischemia due to leukemic infiltration. [ncbi.nlm.nih.gov]

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