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83 Possible Causes for Dyspnea, Hepatomegaly, Postural Defect

  • Amyloidosis

    MGUS and myeloma patients that have atypical features, including unexplained weight loss; lower extremity edema, early satiety, and dyspnea on exertion should be considered[] Hepatic involvement is common, but the clinical manifestations are usually mild with hepatomegaly and an elevated alkaline phosphatase level.[] Flies carrying mutant variants, but not wild-type TTR, exhibit changes in wing posture, locomotor defects, and shortened life span.[]

  • Cardiac Asthma

    Typical signs: tachycardia, tachypnoea, pulmonary rales, pleural effusion, raised jugular venous pressure (JVP), peripheral oedema, hepatomegaly.[] Patients with chronic CHF and orthopnea have a considerable increase in airflow resistance upon adopting the supine posture associated with supine expiratory flow limitation[] The patient appears very ill and experiences severe dyspnea and tachypnea.[]

  • Hepatopulmonary Syndrome

    .- ) cystic disease of liver (congenital) ( Q44.6 ) hepatic vein thrombosis ( I82.0 ) hepatomegaly NOS ( R16.0 ) pigmentary cirrhosis (of liver) ( E83.110 ) portal vein thrombosis[] The former may be an atrial septal defect, a patent foramen ovale, or a fenestrated atrial septal aneurysm.[] CONCLUSIONS: This report identifies HPS as a frequent cause of dyspnea in telomerase and telomere gene mutation carriers.[]

  • Hyperammonemia Type 3

    Despite treatment with an aerosol bronchodilator, she continued to have bronchospasm and dyspnea with wheezes.[] A congenital form occurs in two types: Type 1, due to deficiency of the enzyme ornithine carbamoyltransferase, is marked by vomiting, lethargy, coma, and hepatomegaly; symptoms[] Above 1000 µmol/L: About 50% survive Ammonia levels seen in inborn errors of metabolism: Urea cycle defects: 500 to 2000 µmol/L Organic acidemia: 100 to 1000 µmol/L Transport[]

  • Homocystinuria

    […] inborn error of metabolism of sulfur amino acids due to lack of the enzyme cystathionine synthase; it is characterized by homocystine in the urine and by mental retardation, hepatomegaly[] He offered no insight as to what may have precipitated the event, and could not identify any alleviating or aggravating factors for his dyspnea.[] Many, if not all, patients have some type of hepatic involvement which may produce mild hepatomegaly with imaging characteristics and/or biopsied pathology of fatty infiltration[]

  • Right to Left Shunt

    Hepatomegaly is a common manifestation in Gaucher disease. In some patients with the disease, hepatic fibrosis and portal hypertension are observed.[] Postural cyanosis and angina pectoris following pneumonectomy: relief by closure of an interatrial septal defect.[] We report the case of a 50-yr-old man who experienced exertional dyspnea 5 mo after a left pneumonectomy for carcinoma.[]

  • Congenital Pericardium Anomaly

    Additional symptoms can include vomiting, diarrhea, abdominal pain, and an enlarged liver (hepatomegaly).[] Xenograft pericardioplasty[ 2 ] and defect enlargement by direct excision[ 8 ] have also been performed to treat symptomatic, partial defects of the right pericardium.[] However, some patients are symptomatic, reporting symptoms that include chest pain, palpitations, dyspnea, and syncope.[]

  • Mediastinal Neoplasm

    Large tumors can manifest clinically as cough, dyspnea, chest pain, or pulmonary infection.[] Hoarseness Symptoms of Horner’s syndrome (ptosis, miosis, decreased sweating) Facial/upper limb edema and venous distension in neck and upper limbs/chest Lymphadenopathy Hepatomegaly[] Furthermore, asymmetry of the thoracic-lumbar spinal region was observed, which at first assessment suggested a postural defect.[]

  • Paradoxical Embolism

    Abdominal examination findings revealed massive hepatomegaly and ascites.[] In Patent foramen ovale is the most common cause of paradoxal embolism in cryptogenic stroke or platypnea-orthodeoxia syndrome (postural hypoxemia with breathlessness).[] Emergency Physicians should be aware that dyspnea may be the only initial symptom.[]

  • Left to Right Cardiac Shunt

    […] low cardiac output (poor perfusion, increased lactate, low mixed venous oxygen saturation, low cerebral oxygen saturation), and elevated central venous pressures (edema, hepatomegaly[] Postural cyanosis and angina pectoris following pneumonectomy: relief by closure of an interatrial septal defect.[] Results Patients with symptoms did not differ in age (32.7 10.3 years vs 31.7 11.7 years) from patients who did not present with hypoxia or subjective dyspnea (n 81).[]

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