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20 Possible Causes for Dyspnea, Pancytopenia, Polyclonal Hyperglobulinemia

  • Multicentric Castleman's Disease

    Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present.[ncbi.nlm.nih.gov] He was treated with plasmapheresis, resulting in a transient improvement of dyspnea.[ncbi.nlm.nih.gov] hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[pagepress.org]

  • Primary Myelofibrosis

    This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com] Dyspnea, tachycardia and dizziness are experienced in case of severe anemia.[symptoma.com] Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[patient-help.com]

  • Castleman Disease

    A 36-year-old woman suffering from oral ulcerations, skin rash, and dyspnea was suspected of having paraneoplastic pemphigus.[ncbi.nlm.nih.gov] The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[ncbi.nlm.nih.gov] There is often significant anemia which may be hemolytic, often reflecting pancytopenia or hemophagocytic syndrome (Stebbing 2009).[hivbook.com]

  • HIV Infection

    […] osteomalacia* Protease inhibitors with statins: myopathy Hematologic or oncologic Anemia of chronic disease Lymphoma, multiple myeloma Bone marrow infiltration (leading to pancytopenia[aafp.org] Pneumocystis jiroveci pneumonia: (a) a history of dyspnea on exertion or nonproductive cough of recent onset (within the past 3 months); and (b) chest radiograph evidence[journalofethics.ama-assn.org] Hyperactivation is reflected in dramatic polyclonal hyperglobulinemia, only a portion of which is directed against HIV antigens;(59) bone marrow plasmacytosis;(60) heightened[hivinsite.ucsf.edu]

  • Congenital Intrinsic Factor Deficiency

    Gene GIF (AR) Diagnostic Test Plasma Vitamin B12, Folate Neurological Ataxia, dystonia Non-Neurological Megaloblastic anemia, pancytopenia Treatment HydroxyCobalamin Level[treatable-id.org] The symptoms may include generalized weakness and fatigue, difficulty breathing (dyspnea), an abnormally rapid heartbeat (tachycardia), and/or chest pains (angina).[rarediseases.org] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org]

  • Posthemorrhagic Anaemia of the Newborn

    Asymptomatic in most cases Weakness, fatigue, and/or malaise Exertional dyspnea Angina with coronary artery disease Headaches or inability to concentrate Melena Pica Search[5minuteconsult.com] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org] […] with malformations 284.1 Pancytopenia Excludes: pancytopenia (due to) (with): aplastic anemia NOS (284.9) bone marrow infiltration (284.2) constitutional red blood cell aplasia[theodora.com]

  • Chronic Active Hepatitis

    Abstract A 28-year-old man was admitted to our department with intermittent fever, hepatosplenomegaly and pancytopenia.[ncbi.nlm.nih.gov] We report the case of a 53-year-old female patient, who developed bilateral blepharoptosis, limb weakness, dysphagia, and dyspnea several days after human natural interferon-beta[ncbi.nlm.nih.gov] hyperglobulinemia.[hepatitiscentral.com]

  • MALT Lymphoma

    In most cases, the presenting symptoms are hoarseness, dysphagia, dyspnea, and cervical lymphadenopathy.[ncbi.nlm.nih.gov] Not only MALT lymphoma, but also SjS can cause secondary hyperglobulinemia. Indeed, immunoelectrophoresis-serum test showed a polyclonal pattern of hyperglobulinemia.[ncbi.nlm.nih.gov] In the entire collective, three cases (6%) of prolonged pancytopenia including manifest myelodysplastic syndrome in one patient (2%), three cases (6%) of secondary lymphoid[ncbi.nlm.nih.gov]

  • H Syndrome

    IVIC Syndrome with mild thrombocytopenia and leukocytosis; 4) WT Syndrome involving a wide array of hematologic abnormalities including easy bruising, hypoplastic anemia, pancytopenia[bloodjournal.org] Other manifestations include osteopenia, interstitial pneumonia often causing hypoxemia and dyspnea or localized ground-glass opacities and areas of atelectasis at chest computed[ojrd.biomedcentral.com]

  • Angioimmunoblastic Lymphadenopathy

    Laboratory findings included progressive pancytopenia, hyperuricemia, and acute renal failure. Bone marrow biopsy showed a T cell lymphoid neoplasm that had ...[citeulike.org] In one series, other symptoms included weight loss (58%), hepatomegaly (60%), polyclonal hyperglobulinemia (65%), and generalized adenopathy (87%).[emedicine.medscape.com] […] congestion of the upper part of the thorax and the arms, small mantle edema); b) compression of the bronchial branches (harsh dry cough, mixed or prevalently expiratory dyspnea[kipdf.com]

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