On examination, she had dyspnea at rest, tachypnea, tachycardia, clubbing, bilateral pitting pedal edema and oxygen saturation was maintained only with non-invasive ventilator
[lungindia.com]
PaO2 Alveolar-arterial O2 gradient ≥40 mmHg at rest Severe dyspnea Hypoxemia Contraindication: [42] Clotting disorders Anesthetic risks Cardiopulmonary instability Medical
[wikidoc.org]
Most patients develop dyspnea very slowly over time typically noticing it only with activity at first and eventually also at rest.
[rarediseases.org]