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447 Possible Causes for Dystrophic Changes

  • Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1D

    Muscle biopsy shows dystrophic changes with abnormal nuclei, rimmed vacuoles, and filamentous inclusions. {ECO:0000269 PubMed:23667635}.[] There were also amorphous necrotic muscle fibres with areas of regeneration (dystrophic changes).[] Dystrophies are a group of non-inflammatory hereditary conditions which show dystrophic changes (increased connective tissue, fiber splitting) on biopsy without degeneration[]

  • Amyloidosis

    Lichen amyloidosis (LA) is characterized by the deposition of amyloid that may respond to chronic scratching that may be secondary to atopic dermatitis, stasis dermatitis, or interface dermatitis. Despite the development of several therapeutic strategies, including topical steroids, oral antihistamines, cyclosporine,[…][]

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2G

    A rare autosomal recessive degenerative myopathy (OMIM:601954) characterised by proximal and distal muscle weakness and atrophy in the limbs, dystrophic changes on muscle[] changes on muscle biopsy, and absence of telethonin.[] […] muscular dystrophy 2G (LGMD2G) [MIM:601954]: An autosomal recessive degenerative myopathy characterized by proximal and distal muscle weakness and atrophy in the limbs, dystrophic[]

  • Congenital Muscular Dystrophy

    changes in the muscles.[] Pathological analysis of biopsied skeletal muscle showed dystrophic changes with proliferated fibrotic tissue elements as the predominant finding.[] Serum creatine kinase was elevated, muscle biopsy showed dystrophic changes, and there were abnormalities in brain MRI.[]

  • Distal Myopathy

    changes in muscle biopsy.[] The electromyography showed myopathic patterns and the muscle biopsy disclosed dystrophic changes and an absence of dysferlin.[] Because of the benign evolution and the absence of true dystrophic changes in most biopsies we suggest the term infantile autosomal dominant distal myopathy should be preferred[]

  • Cronkhite-Canada Syndrome

    The disease is characterized by diffuse gastrointestinal polyposis, dystrophic changes of the fingernails, alopecia, cutaneous hyperpigmentation, diarrhea, weight loss, and[] Dystrophic changes of the fingernails and a bilateral thumb abduction deformity were observed. Antinuclear antibodies were elevated.[] A 67-year-old man who underwent severe chronic diarrhea had typical clinical manifestations of hyperpigmentation, hair loss, and dystrophic changes in the fingernails.[]

  • Congenital Merosin-Positive Muscular Dystrophy

    changes on skeletal muscle biopsy.[] In addition to dystrophic changes with necrosis and regeneration in muscle, the most striking finding was mitochondrial depletion in the center of the sarcoplasm.[] […] a heterogeneous group of autosomal recessive disorders, which present within the first 6 months of life with hypotonia, muscle weakness and contractures, associated with dystrophic[]

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2A

    Muscle biopsy revealed a dystrophic change and many lobulated fibers on NADH-tetrazolium reductase staining.[] Additional findings included elevation of serum creatine kinase level, myopathic EMG changes and dystrophic type of pathology on muscle biopsy.[]

  • Alzheimer Disease

    These pathological changes are frequently accompanied by reactive microgliosis and loss of neurons, white matter and synapses.[] changes.[] Curcumin also led to a limited, but significant reversal of structural changes in dystrophic dendrites, including abnormal curvature and dystrophy size.[]

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy

    Histopathology of skeletal muscles biopsies showed typical dystrophic changes with many rimmed vacuoles.[] Muscle biopsy showed dystrophic changes with normal expression of dystrophin and various proteins of the dystrophin-associated protein complex (sarcoglycan sub-units, dystroglycan[] Serum creatine kinase (CK) levels in individuals with LGMD are usually elevated, and muscle biopsy reveals dystrophic changes.[]

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