Create issue ticket

55 Possible Causes for Ear Deformity, Folded Helix, Leukemia

  • Down Syndrome

    (AMKL) and 20 times more likely to develop acute lymphoblastic leukemia (ALL) than typical children.[ncbi.nlm.nih.gov] Patients with Down syndrome (DS) are predisposed to acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) in early and later childhood, respectively, but rarely[ncbi.nlm.nih.gov] Physicians compliance during maintenance therapy in children with Down syndrome and acute lymphoblastic leukemia. Leukemia 2013; 27 : 866–870. 21.[doi.org]

  • Congenital Contractural Arachnodactyly

    Most affected individuals have "crumpled" ears that present as a folded upper helix of the external ear and most have contractures of major joints (knees and ankles) at birth[ncbi.nlm.nih.gov] " deformity.[ncbi.nlm.nih.gov] The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127:2391-2405. Available online at .[labtestsonline.it]

  • Noonan Syndrome-Like Disorder with Juvenile Myelomonocytic Leukemia

    (outer rim) of ear (over 90%) Incomplete folding of ears Chronic otitis media (ear infections) Hearing loss Mouth and speech [ edit ] Deeply grooved philtrum (top lip line[en.wikipedia.org] ; broad neck with low hairline; and thorax deformity), and abnormal skin and adnexa.[clincancerres.aacrjournals.org] leukemia Diagnosis See also related information on diagnosis: Diagnosis of Noonan syndrome Diagnosis of Juvenile myelomonocytic leukemia Treatments See also the following[familydiagnosis.com]

  • Noonan Syndrome

    […] of the ear, incomplete folding of the ears Small, upturned nose Small jaw, crowding of the lower teeth Deeply grooved philtrum (top lip line), high arched palate Excess skin[dovemed.com] Clinical features are short stature, low-set ears and many minor skeletal deformities of which the commonest are pectus excavatum and cubitus valgus.[whonamedit.com] NS patients show a predisposition to malignancy; however, acute lymphoblastic leukemia (ALL) is rarely reported.[ncbi.nlm.nih.gov]

  • Ondine Syndrome

    […] and antimongoloid slant of eyes, ears deformed with broad slightly irregular flattened helix and fixed lobes, prominent glabella, broad root of nose, asymmetry of shape of[doi.org] Pitt-Hopkins syndrome Primary sclerosing cholangitis Rubinstein-Taybi syndrome due to EP300 haploinsufficiency Autosomal agammaglobulinemia Precursor B-cell acute lymphoblastic leukemia[csbg.cnb.csic.es] […] with attached lobes; the case with the 4p12-15 deletion was described as having the left half of skull flattened, epicanthic folds and antimongoloid slant of eyes, ears deformed[doi.org]

  • Osteogenesis Imperfecta

    Complex dysfunction leads to delayed folding of the procollagen triple helix and increased helical modification.[ncbi.nlm.nih.gov] Hearing loss may be caused by deformities of the bones of the inner ear as well as pressure on the auditory nerve because of deformity of its canal in the skull .[britannica.com] […] dysplasia (see these terms), non-accidental injury (multiple fractures without osteoporosis), and osteoporosis due to medication, nutritional deficiency, metabolic disease, or leukemia[orpha.net]

  • Marfan Syndrome

    Most affected individuals have "crumpled" ears that present as a folded upper helix of the external ear and most have contractures of major joints (knees and ankles) at birth[ncbi.nlm.nih.gov] Chronic myeloid leukemia, conserved biosystem (from KEGG) Chronic myeloid leukemia, conserved biosystem Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder[ncbi.nlm.nih.gov] Most affected individuals have "crumpled" ears, with a folded upper helix, and most have contractures of knees and ankles at birth that usually improve with time.[ncbi.nlm.nih.gov]

  • Central Sleep Apnea

    […] and antimongoloid slant of eyes, ears deformed with broad slightly irregular flattened helix and fixed lobes, prominent glabella, broad root of nose, asymmetry of shape of[doi.org] We describe a child with acute myeloid leukemia (AML) who developed severe central sleep apnea (CSA) on methadone therapy for chronic pain management.[ncbi.nlm.nih.gov] […] with attached lobes; the case with the 4p12-15 deletion was described as having the left half of skull flattened, epicanthic folds and antimongoloid slant of eyes, ears deformed[doi.org]

  • Branchio-Oculo-Facial Syndrome

    Over-folded or malformed ears Sensorineural hearing loss Supra-auricular sinuses Limbs Abnormality Clinodactyly Show images Polydactyly Show images Neurologic Abnormality[datagenno.com] […] of both the external and middle ear structures.[ipfs.io] […] with maturation Acute myeloblastic leukemia without maturation Acute myelomonocytic leukemia Acute promyelocytic leukemia Familial adenomatous polyposis due to 5q22.2 microdeletion[csbg.cnb.csic.es]

  • Cleft Palate

    Clinically observed mutations to the PHF8 gene cluster in exons encoding for the double stranded β-helix fold and will therefore disrupt catalytic activity.[doi.org] […] center provides comprehensive care for children and treats conditions such as: Cleft lip and palate Nasal speech caused by Velopharyngeal insufficiency Genetic syndromes Ear[boystownhospital.org] MN1, initially cloned from a patient with meningioma, is an oncogene in murine hematopoiesis and participates as a fusion gene (TEL/MN1) in human myeloid leukemias.[ncbi.nlm.nih.gov]

Similar symptoms