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10 Possible Causes for Ear Deformity, Single Transverse Palmar Crease, Wide Space Between the First and Second Toe

  • Down Syndrome

    transverse palmar crease, and short fifth finger with clinodactyly.[dx.doi.org] spacing, often with a deep plantar groove between the first and second toes.[dx.doi.org] transverse palmar creases ( 60% of patients) Joint hyperextensibility or hyperflexibility Neuromuscular hypotonia Diastasis recti Dry skin Premature aging Congenital heart[emedicine.medscape.com]

  • Seckel Syndrome

    transverse palmar crease 0000954 Sloping forehead Inclined forehead Receding forehead [ more ] 0000340 Small anterior fontanelle 0000237 Small for gestational age Birth weight[rarediseases.info.nih.gov] ears lacking lobules, skeletal malformations, mental retardation, and developmental delay.[ncbi.nlm.nih.gov] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov]

  • Ring Chromosome 10

    Their common features were mental and growth retardation, low birth weight, microcephaly, stubby nose, hypertelorism, strabismus, wide set nipples, single transverse palmar[ncbi.nlm.nih.gov] GTG banding manifestations include hypotonia, foot deformation, karyotype in our patient revealed that the 18p11.32 proximally placed thumbs, arthritis/stenotic ear and canals[docksci.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Atelosteogenesis Type 2

    transverse palmar creases.[documents.tips] Associated malformations include urinary tract duplication, hydronephrosis, cleft palate, ear deformities, corneal clouding and blue sclera, anal atresia and aplastic testis[fetalultrasound.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Seckel Syndrome Type 2

    transverse palmar crease 0000954 Sloping forehead Inclined forehead Receding forehead [ more ] 0000340 Small anterior fontanelle 0000237 Small for gestational age Birth weight[rarediseases.info.nih.gov] Auricular malformation Deformed ears Malformed ears Simple ears [ more ] 0000377 Abnormally large globe Increased size of eyes Large eyes [ more ] 0001090 Autosomal recessive[rarediseases.info.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Cutis Laxa

    Many patients exhibit single transverse palmar creases.[scielo.br] The face had a senile appearance with pendulous ear lobes and lax skin (Figure 1). His thorax is deformed with scoliosis.[panafrican-med-journal.com] The ears were overfolded and the helices were flattened bilaterally (fig 2 ). The hands and feet were disproportionately large.[jmg.bmj.com]

  • Baraitser Syndrome

    transverse palmar crease Intestinal malrotation Premature birth Growth hormone deficiency Fine hair Hypoglycemia Macrocephaly Frontal bossing Behavioral abnormality Pes planus[mendelian.co] ) short stature during childhood (generally normal birth parameters and less evident in adulthood) chest deformities (superior pectus carinatum with inferior pectus excavatum[invitae.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Tricho-Oculo-Dermo-Vertebral Syndrome

    transverse palmar crease Facial wrinkling Hip contracture Abnormality of primary teeth Subglottic stenosis Midface retrusion Tracheal stenosis Poor wound healing Sparse eyebrow[mendelian.co] Note the ear deformity in (A) and the preauricular pit in (B). From Pierides AM, Athanasiou Y, Demetriou K, Koptides M, Deltas CC.[entokey.com] space between the first and second toes, and fusion of carpal and tarsal bones.[findzebra.com]

  • Heimler Syndrome

    transverse palmar crease Full cheeks Thick eyebrow Delayed speech and language development Tics Pica Motor delay Apnea Postnatal growth retardation Respiratory distress Cleft[mendelian.co] Associated defects * Long narrow faces. * Facial paralysis. * Cysts/ fistulas of the neck. * Constricted palates/ Cleft. * Deep overbite. * Ear pits. * Lop ear deformity.[thecainfoundation.com] spaced teeth Finger clinodactyly Mutism Incoordination Sleep apnea Plantar crease between first and second toes Supernumerary nipple Clubbing Radial deviation of thumb terminal[mendelian.co]

  • Macrocephaly-Developmental Delay Syndrome

    transverse palmar crease - Pelvic dysplasia Other feats: Craniofacial - brachycephaly, flat occiput, prominent epicanthal folds, speckled irises (Brushfield spots), 3 fontanelles[quizlet.com] […] of auricle or external ear canal Hearing loss Enlarged pinna, macroorchidism Fragile X syndrome Upward slanting eyes, Brushfield spots, epicanthic folds, brachycephaly, simian[aafp.org] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org]