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22 Possible Causes for Earlier Onset Is Associated with More Rapid Progression

  • Pallidopyramidal Syndrome

    […] dosage effect is present, in which triplications are associated with a 100% increase in protein expression resulting in a younger age-of-onset and more rapid disease progression[acnr.co.uk] Disease-onset associated with duplications occurs at around 50 years and the age-of-onset associated with triplications is earlier at 38 years ( /-13). 10 Therefore a gene[acnr.co.uk]

  • Muscular Dystrophy

    The more common autosomal recessive subtypes usually have an earlier age of onset and show more rapid disease progression compared with AD variants.[doi.org] The subtypes mostly associated with cardiac involvement (manifested as conduction disorders and/or myocardial disease) are those associated with a defect in the genes coding[doi.org]

  • Duchenne Muscular Dystrophy

    The more common autosomal recessive subtypes usually have an earlier age of onset and show more rapid disease progression compared with AD variants.[doi.org] The subtypes mostly associated with cardiac involvement (manifested as conduction disorders and/or myocardial disease) are those associated with a defect in the genes coding[doi.org]

  • Spinal and Bulbar Muscular Atrophy

    As with other trinucleotide repeat disorders, anticipation is frequently observed and larger CAG expansions are associated with earlier onset and a more rapid clinical progression[mayomedicallaboratories.com] There is no consensus as to the clinical significance of alleles of 35 CAG repeats and literature suggests that alleles of 36 to 37 CAG repeats may be associated with reduced[mayomedicallaboratories.com]

  • Becker Muscular Dystrophy

    The more common autosomal recessive subtypes usually have an earlier age of onset and show more rapid disease progression compared with AD variants.[doi.org] The subtypes mostly associated with cardiac involvement (manifested as conduction disorders and/or myocardial disease) are those associated with a defect in the genes coding[doi.org]

  • Juvenile Paralysis Agitans of Hunt

    […] dosage effect is present, in which triplications are associated with a 100% increase in protein expression resulting in a younger age-of-onset and more rapid disease progression[acnr.co.uk] Disease-onset associated with duplications occurs at around 50 years and the age-of-onset associated with triplications is earlier at 38 years ( /-13). 10 Therefore a gene[acnr.co.uk]

  • Glycogen Storage Disease Type 2

    Earlier onset compared to later onset is usually associated with more rapid progression and greater disease severity.[rarediseases.org] […] and different ages of onset.[rarediseases.org] […] acid maltase deficiency (AMD acid alpha-glucosidase (GAA) deficiency General Discussion Summary Pompe disease is a single disease continuum with variable rates of disease progression[rarediseases.org]

  • Spinal Muscular Atrophy

    In one patient, earlier onset before the age of 2 years was associated with a more complex clinical picture, with abnormal eye movements, progressive cognitive impairment,[ncbi.nlm.nih.gov] […] and a more rapid and severe course.[ncbi.nlm.nih.gov] […] were onset in childhood with proximal muscular weakness, generalized epilepsy with absences and myoclonic seizures, cognitive impairment of variable degree; the course was progressive[ncbi.nlm.nih.gov]

  • Spinocerebellar Ataxia Type 1

    rapid progression than SCA2 and because SCA1 is often associated with heavier involvement of the pyramidal tract, whereas SCA2 is often associated with earlier onset of disturbances[ajnr.org] – 10 Although no treatment is available, from a clinical viewpoint differentiating the 2 subtypes is important for prognostic purposes, because SCA1 is characterized by more[ajnr.org]

  • Autosomal Recessive Parkinson Disease 14

    […] dosage effect is present, in which triplications are associated with a 100% increase in protein expression resulting in a younger age-of-onset and more rapid disease progression[es.slideshare.net] Disease-onset associated with duplications occurs at around 50 years and the age-of-onset associated with triplications is earlier at 38 years ( /-13). 10 Therefore a gene[acnr.co.uk] Disease-onset associated with duplications occurs at around 50 years and the age-of-onset associated with triplications is earlier at 38 years ( /-13).10 Therefore a gene[es.slideshare.net]

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