Early Age of Onset: Causes & Reasons

Possible Causes for Early Age of Onset

In general, most neurologists agree that early-onset and late-onset Alzheimer’s are essentially the same disease, apart from the differences in genetic cause and age of onset [salon.com]

Those with early-onset familial AD are likely to develop AD before the age of 65 and are likely to have family members who also have early-onset AD. [ncrad.iu.edu]

Types of Alzheimer’s Disease Early Onset In early onset Alzheimer’s disease, symptoms first appear before age 60. [mercyhealth.com]

Nestor-Guillermo Progeria Syndrome

Néstor–Guillermo progeria syndrome: A novel premature aging condition with early onset and chronic development caused by BANF1 mutations. [onlinelibrary.wiley.com]

@article{Cabanillas2011NstorGuillermoPS, title={N{\'e}stor-Guillermo progeria syndrome: a novel premature aging condition with early onset and chronic development caused by [semanticscholar.org]

"Néstor-Guillermo progeria syndrome: a novel premature aging condition with early onset and chronic development caused by BANF1 mutations". [en.wikipedia.org]

Late-Onset Depression

[…] disease (PD) began before age 55 (early-onset group) compared with patients whose onset was after age 55 (late-onset group). [neurology.org]

Fifteen patients (20.3%) had an early onset of depression (before age 60 years) and 59 (79.7%) had a late onset of depression. [ncbi.nlm.nih.gov]

Twelve had late-onset depression (first episode over 55 years of age); 11 had early onset (first episode before 50 years). [ncbi.nlm.nih.gov]

Bidirectional Tachycardia

An early age of onset and mortality as high as 30% by the age of 30 years has recently been described.8 In a normal cardiac cell, depolarization of the membrane initiates [ncbi.nlm.nih.gov]

Childhood Schizophrenia

Early-onset schizophrenia occurs before age 18. Very early-onset schizophrenia in children younger than age 13 is extremely rare. [mayoclinic.com]

Childhood-onset schizophrenia is defined as schizophrenia with onset prior to the age of 13 years, and early-onset schizophrenia describes schizophrenia between the ages of [library.neura.edu.au]

With childhood schizophrenia, the early age of onset presents special challenges for diagnosis, treatment, education, and emotional and social development. [mayoclinic.com]

Adult-Onset Dystonia - Parkinsonism

Early-onset cases that begin before age 20 may be referred to as juvenile-onset disease. [flybase.org]

The condition is described as early-onset disease if signs and symptoms begin before age 50. [snpedia.com]

Early-onset cases that begin before age 20 are sometimes referred to as juvenile-onset Parkinson disease. [ghr.nlm.nih.gov]

North Carolina Macular Dystrophy

Conclusions: North Carolina macular dystrophy has a wide spectrum of clinical phenotypes that resemble age-related macular degeneration except for their early age of onset [jhu.pure.elsevier.com]

CONCLUSIONS: North Carolina macular dystrophy has a wide spectrum of clinical phenotypes that resemble age-related macular degeneration except for their early age of onset [ncbi.nlm.nih.gov]

North Carolina macular dystrophy has many phenotypic similarities to age-related macular degeneration with the glaring exception of the early age of onset of North Carolina [ncbi.nlm.nih.gov]

BSCL2-Related Neurologic Disorders

The case with p.N88T mutation showed severe phenotype such as early onset age and prominent vocal cord paresis. [pubmed.ncbi.nlm.nih.gov]

Neuronal Ceroid Lipofuscinosis Type 11

A childhood/juvenile form is characterized by classical CLN11 symptoms at an early age at onset. [hal.archives-ouvertes.fr]

The phenotypic spectrum is much broader than previously reported, with two remarkably distinct presentations, depending on the age of onset. [hal.archives-ouvertes.fr]

Intermittent Explosive Disorder

These studies show that IED is a commonly occurring disorder that typically has an early age of onset, a persistent course, and strong comorbidity with a number of other usually [oxfordhandbooks.com]

Early-Onset Cerebellar Ataxia

Abstract A clinical and genetic study was performed on 20 patients affected by early onset cerebellar ataxia with retained tendon reflexes (EOCA). [ncbi.nlm.nih.gov]

Mean age at onset was 8.8 (SD 6.0) years. The frequency distribution of age of onset significantly differed from the normal distribution. [ncbi.nlm.nih.gov]

While most small vessel diseases appear sporadic and related to age and hypertension, several early-onset monogenic forms have also been reported. [pubmed.ncbi.nlm.nih.gov]

Aicardi-Goutières Syndrome Type 4

Symptoms of early-onset AGS Infants with early-onset AGS have jittery behavior and poor feeding ability from birth. [chop.edu]

Most characteristically, Aicardi-Goutières syndrome (AGS) manifests as an early-onset encephalopathy that usually, but not always, results in severe intellectual and physical [ncbi.nlm.nih.gov]

AGS was defined as a neurological disease with an early age of onset and a progressive course [1]. [link.springer.com]

Early-Onset Alzheimer Disease Type 3

What is early-onset Alzheimer's? Early-onset Alzheimer's is an uncommon form of dementia that affects people younger than age 65. [mayoclinic.org]

Description Transcript Keywords Info Professor Donna Wilcock discusses early-onset Alzheimer's disease, which can reach an advanced stage by the age of 50 or 60 years. [dnalc.cshl.edu]

Those with early-onset familial AD are likely to develop AD before the age of 65 and are likely to have family members who also have early-onset AD. [ncrad.iu.edu]

Verrucous Nevus

Altman and Mehregan described six characteristic features of ILVEN: (1) early age of onset, (2) predominance in females (4:1 female-male ratio), (3) frequent involvement of [en.wikipedia.org]

Aicardi-Goutières Syndrome Type 5

Symptoms of early-onset AGS Infants with early-onset AGS have jittery behavior and poor feeding ability from birth. [chop.edu]

A correlation was found between early age at onset and severity of the leukoencephalopathy in the frontal (P = .024) and temporal (P = .034) regions. [ajnr.org]

Aicardi-Goutières Syndrome Type 3

Symptoms of early-onset AGS Infants with early-onset AGS have jittery behavior and poor feeding ability from birth. [chop.edu]

AGS was defined as a neurological disease with an early age of onset and a progressive course [1]. [link.springer.com]

Aicardi-Goutières Syndrome Type 1

Symptoms of early-onset AGS Infants with early-onset AGS have jittery behavior and poor feeding ability from birth. [chop.edu]

Children with early-onset AGS have the highest risk of death. [ninds.nih.gov]

Ataxia-Telangiectasia-Like Disorder

Ataxia with oculomotor apraxia types 1 and 2 (AOA1 and AOA2) are autosomal recessive ataxias characterized by an early age of onset. [ncbi.nlm.nih.gov]

The median age at onset of ataxia in our patients was 2.8 years (extremes: 13 months and 6 years).Among the other classic early features of A-T slurred speech, oculomotorapraxia [latunisiemedicale.com]

DISCUSSION A-T is primarily an early-onset, progressive, neurodegenerative disorder [11] that is transmitted as an autosomal recessive disorder with a frequency of 1/100,000live [latunisiemedicale.com]

Aicardi-Goutières Syndrome Type 6

Symptoms of early-onset AGS Infants with early-onset AGS have jittery behavior and poor feeding ability from birth. [chop.edu]

AGS was defined as a neurological disease with an early age of onset and a progressive course [1]. [link.springer.com]

Aicardi-Goutières Syndrome Type 7

Symptoms of early-onset AGS Infants with early-onset AGS have jittery behavior and poor feeding ability from birth. [chop.edu]

AGS was defined as a neurological disease with an early age of onset and a progressive course [1]. [link.springer.com]

Blount Disease

Based on whether the deformity is first noted before or after 4 years of age, early-onset and late-onset forms of Blount disease have been described. [scienceopen.com]

Familial Melanoma of the Lip

They identified families where melanoma cosegregates with loss-of-function variants in the POT1 gene, with a proportion of family members presenting with an early age of onset [esmo.org]

age of onset. [en.wikipedia.org]

age at onset, and multiple synchronous or asynchronous tumors. [nejm.org]

UNC80 Deficiency

Joint contractures (e.g., hip, elbow, knee) can present from an early age. Later-onset scoliosis can be seen. [ncbi.nlm.nih.gov]

Leber Congenital Amaurosis Type 10

0.001), namely cone-rod dystrophy and early-onset severe forms on the one hand (mean age of onset = 7.6 years), late-onset mild forms and senile forms on the other. [scienceopen.com]

[…] on the age at onset of symptoms, severity of visual loss, and associated nonocular abnormalities. [scienceopen.com]

Record: found Abstract: found Article: not found Classification of congenital and early onset retinitis pigmentosa. [scienceopen.com]

Developmental and Epileptic Encephalopathy Type 1

It has an early onset and symptoms generally occur before the age of one, with seizures often beginning before the tenth day of life. [news-medical.net]

Early infantile epileptic encephalopathy (EIEE), also called Ohtahara syndrome, is a rare disorder characterized by infantile spasms. [news-medical.net]

Charcot-Marie-Tooth Disease Type 4A

CMT4A is a severe form characterized by early age of onset and rapid progression leading to inability to walk in late childhood or adolescence. [uniprot.org]

CMT4C is characterized by early-onset severe spine deformities. [charcot-marie-toothnews.com]

Age at onset ranges from infancy to early childhood. In most cases, disease progression causes disabilities within the first or second decade of life. [ncbi.nlm.nih.gov]

Spastic Paraplegia with Extrapyramidal Signs

[…] as the age of 28 years. [link.springer.com]

Neuroreport 9(2): 217–1 CrossRef CAS PubMed Google Scholar Golan MP, Styczyńska M, Jóźwiak K, et al. (2007) Early-onset Alzheimer’s disease with a de novo mutation in the [link.springer.com]

USA 99(12): 8025–30 CrossRef CAS PubMed Google Scholar Miklossy J, Taddei K, Suva D, et al. (2003) Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset [link.springer.com]

Facial Psoriasis

Patients who have a long duration of psoriasis or early age of onset are more likely to suffer from facial involvement. [jddonline.com]

Familial Melanoma of the Eyelid

age at onset, and multiple synchronous or asynchronous tumors. [nejm.org]

Early age of onset and multiple nevi were once thought to be risk factors for having heritable melanoma. [aimatmelanoma.org]

[…] at an early age. [dnatesting.uchicago.edu]