Early Age of Onset: Causes & Reasons

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Possible Causes for Early Age of Onset

Early-Onset Alzheimer Disease

In general, most neurologists agree that early-onset and late-onset Alzheimer’s are essentially the same disease, apart from the differences in genetic cause and age of onset [salon.com]

Those with early-onset familial AD are likely to develop AD before the age of 65 and are likely to have family members who also have early-onset AD. [ncrad.iu.edu]

Types of Alzheimer’s Disease Early Onset In early onset Alzheimer’s disease, symptoms first appear before age 60. [mercyhealth.com]

Nestor-Guillermo Progeria Syndrome

Néstor–Guillermo progeria syndrome: A novel premature aging condition with early onset and chronic development caused by BANF1 mutations. [onlinelibrary.wiley.com]

"Néstor-Guillermo progeria syndrome: a novel premature aging condition with early onset and chronic development caused by BANF1 mutations". [en.wikipedia.org]

@article{Cabanillas2011NstorGuillermoPS, title={N{\'e}stor-Guillermo progeria syndrome: a novel premature aging condition with early onset and chronic development caused by [semanticscholar.org]

Childhood Schizophrenia

Early-onset schizophrenia occurs before age 18. Very early-onset schizophrenia in children younger than age 13 is extremely rare. [mayoclinic.com]

With childhood schizophrenia, the early age of onset presents special challenges for diagnosis, treatment, education, and emotional and social development. [mayoclinic.com]

Identifying and starting treatment for childhood schizophrenia as early as possible may significantly improve your child's long-term outcome. [mayoclinic.com]

Late-Onset Depression

[…] disease (PD) began before age 55 (early-onset group) compared with patients whose onset was after age 55 (late-onset group). [neurology.org]

Fifteen patients (20.3%) had an early onset of depression (before age 60 years) and 59 (79.7%) had a late onset of depression. [ncbi.nlm.nih.gov]

Twelve had late-onset depression (first episode over 55 years of age); 11 had early onset (first episode before 50 years). [ncbi.nlm.nih.gov]

Aicardi-Goutières Syndrome Type 7

Symptoms of early-onset AGS Infants with early-onset AGS have jittery behavior and poor feeding ability from birth. [chop.edu]

AGS was defined as a neurological disease with an early age of onset and a progressive course [1]. [link.springer.com]

A correlation was found between early age at onset and severity of the leukoencephalopathy in the frontal (P = .024) and temporal (P = .034) regions. [ajnr.org]

Aicardi-Goutières Syndrome Type 3

Symptoms of early-onset AGS Infants with early-onset AGS have jittery behavior and poor feeding ability from birth. [chop.edu]

Most characteristically, Aicardi-Goutières syndrome (AGS) manifests as an early-onset encephalopathy that usually, but not always, results in severe intellectual and physical [ncbi.nlm.nih.gov]

AGS was defined as a neurological disease with an early age of onset and a progressive course [1]. [link.springer.com]

BSCL2-Related Neurologic Disorders

The case with p.N88T mutation showed severe phenotype such as early onset age and prominent vocal cord paresis. [pubmed.ncbi.nlm.nih.gov]

Intermittent Explosive Disorder

These studies show that IED is a commonly occurring disorder that typically has an early age of onset, a persistent course, and strong comorbidity with a number of other usually [oxfordhandbooks.com]

Congenital Disorder of Glycosylation Type X

He experienced loss of vision with associated roving eye movements between ages 2 and 3 years. He also presented with early-onset nyctalopia and high myopia (Table). [jamanetwork.com]

[…] been highlighted: a systemic disease with encephalopathy or congenital myasthenic syndrome with tubular aggregates in muscle biopsy. 54% of patients were treated because of early-onset [mdpi.com]

Detailed ocular phenotyping identified early-onset (aged ≤3 years) visual loss (mean [SD] best-corrected visual acuity, +0.95 [0.34] logMAR [20/180 Snellen]), childhood-onset [jamanetwork.com]

UNC80 Deficiency

Joint contractures (e.g., hip, elbow, knee) can present from an early age. Later-onset scoliosis can be seen. [ncbi.nlm.nih.gov]

Bidirectional Tachycardia

An early age of onset and mortality as high as 30% by the age of 30 years has recently been described.8 In a normal cardiac cell, depolarization of the membrane initiates [ncbi.nlm.nih.gov]

Verrucous Nevus

Altman and Mehregan described six characteristic features of ILVEN: (1) early age of onset, (2) predominance in females (4:1 female-male ratio), (3) frequent involvement of [en.wikipedia.org]

Frontotemporal Dementia with Motor Neuron Disease Type 2

Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration. Neurology. 2018;90: e1047-56. [ Links ] 37. [scielo.org.pe]

Late-Onset Schizophrenia. Epidemiology, Diagnosis, Management and Outcomes. Drugs & Aging, 1999; 15: 81-89. [ Links ] 36. [scielo.org.pe]

Aicardi-Goutières Syndrome Type 5

Symptoms of early-onset AGS Infants with early-onset AGS have jittery behavior and poor feeding ability from birth. [chop.edu]

Early-Onset Form The early-onset form affects about 20 percent of babies affected by AGS. [huntershope.org]

Early-onset AGS is the more serious form of the syndrome. [chop.edu]

Early-Onset Alzheimer Disease Type 3

What is early-onset Alzheimer's? Early-onset Alzheimer's is an uncommon form of dementia that affects people younger than age 65. [mayoclinic.org]

Description Transcript Keywords Info Professor Donna Wilcock discusses early-onset Alzheimer's disease, which can reach an advanced stage by the age of 50 or 60 years. [dnalc.cshl.edu]

Patients with very early-onset Alzheimer’s disease (VEOAD) usually have an age of onset before the age of 35 years. [hindawi.com]

Aicardi-Goutières Syndrome Type 1

Symptoms of early-onset AGS Infants with early-onset AGS have jittery behavior and poor feeding ability from birth. [chop.edu]

Early-Onset Form The early-onset form affects about 20 percent of babies affected by AGS. [huntershope.org]

Charcot-Marie-Tooth Disease Type 4A

CMT4A is a severe form characterized by early age of onset and rapid progression leading to inability to walk in late childhood or adolescence. [uniprot.org]

CMT4C is characterized by early-onset severe spine deformities. [charcot-marie-toothnews.com]

Age at onset ranges from infancy to early childhood. In most cases, disease progression causes disabilities within the first or second decade of life. [ncbi.nlm.nih.gov]

Hereditary Ataxia Type Schut-Book

onset occurring before the age of 20 years. [biblioteca.versila.com]

[…] case other systems and organs, and characterized by degeneration or abnormal development of cerebellum and spinal cord, autosomal recessive inheritance and, in most cases, early [biblioteca.versila.com]

Adult-Onset Dystonia - Parkinsonism

Early-onset cases that begin before age 20 may be referred to as juvenile-onset disease. [flybase.org]

The condition is described as early-onset disease if signs and symptoms begin before age 50. [snpedia.com]

Early-onset cases that begin before age 20 are sometimes referred to as juvenile-onset Parkinson disease. [ghr.nlm.nih.gov]

Aicardi-Goutières Syndrome Type 4

A subgroup of infants with AGS present at birth with abnormal neurologic findings, hepatosplenomegaly, elevated liver enzymes, and thrombocytopenia, a picture highly suggestive [ncbi.nlm.nih.gov]

Developmental and Epileptic Encephalopathy Type 1

It has an early onset and symptoms generally occur before the age of one, with seizures often beginning before the tenth day of life. [news-medical.net]

Early infantile epileptic encephalopathy (EIEE), also called Ohtahara syndrome, is a rare disorder characterized by infantile spasms. [news-medical.net]

North Carolina Macular Dystrophy

CONCLUSIONS: North Carolina macular dystrophy has a wide spectrum of clinical phenotypes that resemble age-related macular degeneration except for their early age of onset [ncbi.nlm.nih.gov]

Conclusions: North Carolina macular dystrophy has a wide spectrum of clinical phenotypes that resemble age-related macular degeneration except for their early age of onset [jhu.pure.elsevier.com]

North Carolina macular dystrophy has many phenotypic similarities to age-related macular degeneration with the glaring exception of the early age of onset of North Carolina [ncbi.nlm.nih.gov]

Dowling-Degos Disease

To our knowledge our cohort is the largest one described where patients concomitantly affected by DDD and HS and featured by early age of onset, a family history of DDD or [medicaljournals.se]

Early-Onset Cerebellar Ataxia

Abstract A clinical and genetic study was performed on 20 patients affected by early onset cerebellar ataxia with retained tendon reflexes (EOCA). [ncbi.nlm.nih.gov]

Mean age at onset was 8.8 (SD 6.0) years. The frequency distribution of age of onset significantly differed from the normal distribution. [ncbi.nlm.nih.gov]

Sebocystomatosis

Age In the classic presentation, cysts manifest during adolescence and early adulthood, with average age of onset of 26 years. [2] Cases of steatocystoma multiplex presenting [emedicine.medscape.com]

In previous reports, specific mutations were attributed to early-onset cyst formation in pachyonychia congenita type 2 and steatocystoma multiplex; however, more recent reports [emedicine.medscape.com]

[…] suggest that the age of onset is multifactorial. [3] Steatocystoma multiplex is associated with eruptive vellus hair cysts (EVHCs). [emedicine.medscape.com]

Facial Psoriasis

Patients who have a long duration of psoriasis or early age of onset are more likely to suffer from facial involvement. [jddonline.com]

Aicardi-Goutières Syndrome Type 2

Symptoms of early-onset AGS Infants with early-onset AGS have jittery behavior and poor feeding ability from birth. [chop.edu]

Early-Onset Form The early-onset form affects about 20 percent of babies affected by AGS. [huntershope.org]

Most characteristically, Aicardi-Goutières syndrome (AGS) manifests as an early-onset encephalopathy which results in severe intellectual and physical disabilities. [centogene.com]

Familial Melanoma of the Lip

They identified families where melanoma cosegregates with loss-of-function variants in the POT1 gene, with a proportion of family members presenting with an early age of onset [esmo.org]

age of onset. [en.wikipedia.org]

age at onset, and multiple synchronous or asynchronous tumors. [nejm.org]

Chronic Depression

Thase: age at onset. [ncbi.nlm.nih.gov]

Early onset (diagnosis before age 21) is associated with more frequent relapses, psychiatric hospitalizations, and more co-occurring conditions. [12] For younger adults with [en.wikipedia.org]

age at onset and a chronic course of illness. [ncbi.nlm.nih.gov]

Atypical Depression

Early age at onset, predominance in women, outpatient status, mild intensity, rarity of attempted suicide, nonbipolarity, nonendogenicity, and minimal psychomotor change are [ncbi.nlm.nih.gov]

Hardly "atypical" in contemporary contexts, atypical depression also is common in dysthymic bipolar II disorders and is notable for its early age at onset, more chronic course [ncbi.nlm.nih.gov]