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3,954 Possible Causes for Early-Onset Coronary Artery Stenosis, Hearing Impairment, Thickened Aortic Valve

  • Mucopolysaccharidosis 1H

    onset severe regurgitation and stenosis coronary artery disease cardiomegaly: initially hypertrophic then dilated Other features include prominent perivascular spaces hepatosplenomegaly[radiopaedia.org] Cardiopulmonary: Cardiopulmonary manifestations include aortic valve dysfunction and frequent upper and lower respiratory tract infections.[symptoma.com] Hearing impairment. Mental retardation. Inguinal hernias. Joint stiffness and skeletal deformities Coronary heart disease. Hepatosplenomegaly.[medigoo.com]

  • Mucopolysaccharidosis 1 H-S

    onset severe regurgitation and stenosis coronary artery disease cardiomegaly: initially hypertrophic then dilated Other features include prominent perivascular spaces hepatosplenomegaly[radiopaedia.org] […] disease with thickening and leaking of valves most commonly the mitral and aortic valves.[rarediseases.org] Hearing impairment. Umbilical hernias and inguinal hernias. Joint stiffness and skeletal deformities. Cardiomyopathy and coronary heart disease. Hepatosplenomegaly.[patient.info]

  • Mucopolysaccharidosis

    Autopsy showed thickened and stenotic aortic valve leaflets as well as marked concentric intimal thickening of the aorta and muscular arteries.[ncbi.nlm.nih.gov] During 36 months of ERT, symptoms typical of MPS VI including short stature, progressive dysmorphic facial features, hepatosplenomegaly, hearing impairment, corneal clouding[ncbi.nlm.nih.gov] After 4 months of treatment, partial inhibition of CtsB activity in treated mice reduced aortic dilatation, as well as heart valve thickening, and led to improvements in cardiac[ncbi.nlm.nih.gov]

    Missing: Early-Onset Coronary Artery Stenosis
  • Parkinson's Disease

    The surgeon described the leaflets of the mitral and aortic valves in this patient as diffusely thickened and retracted, but no pathologic specimen was available for our examination[content.nejm.org] In other words, they realize that what they’re seeing (or hearing) isn’t actually there. But this may worsen over time.[psychcentral.com] Clinical Events After echocardiographic examination during the study, one 69-year-old man who was taking pergolide underwent mitral-valve and aortic-valve replacement for[content.nejm.org]

    Missing: Early-Onset Coronary Artery Stenosis
  • Herpes Zoster Oticus

    valve sclerosis (AVSc) is characterized by non-uniform thickening of the leaflets without hemodynamic changes.[mdpi.com] Hearing impairment is more severe in patients with vertigo than in those without vertigo in both the high and low frequency ranges, even though the degree of hearing impairment[ncbi.nlm.nih.gov] impairment are reported.[symptoma.com]

    Missing: Early-Onset Coronary Artery Stenosis
  • Mucopolysaccharidosis 4A

    Transthoracic echocardiography showed mildly thickened aortic and mitral valves and a grade 2 left ventricle with a well-delineated, thin-walled apical aneurysm measuring[ahajournals.org] In general, MPS-IVA patients show normal intelligence, but visual impairment and hearing loss are regularly reported.[symptoma.com] Early onset coronary heart disease and valve thickening (aortic and mitral) with resultant cardiac dysfunction are described in these patients, and endocarditis prophylaxis[cjhr.org]

    Missing: Early-Onset Coronary Artery Stenosis
  • Fabry Disease

    Valves were examined for the presence of focal or diffuse thickening of the leaflets or subvalvular apparatus (for the mitral valve).[pediatrics.aappublications.org] Configuration of hearing loss was classified according to the European Working Group on Genetics of Hearing Impairment.[ncbi.nlm.nih.gov] Renal and cardiac impairment influenced the severity of hearing loss (p 0.05). CONCLUSIONS: High frequency hearing loss is a common problem in patients with FD.[ncbi.nlm.nih.gov]

    Missing: Early-Onset Coronary Artery Stenosis
  • Mucopolysaccharidosis 2

    Also, a mildly thickened aortic and tricuspid valve with mild tricuspid and moderate aortic regurgitation were seen. No pericardial effusion or thrombi were found.[karger.com] The symptoms usually include hearing impairment, carpal tunnel syndrome, joint stiffness, discrete corneal opacities, and papilledema.[icd10data.com] Typical signs and symptoms include: Hearing impairment Joint stiffness Coarse face Upper airway disease Carpal tunnel syndrome Communicating hydrocephalus Retinal degeneration[symptoma.com]

    Missing: Early-Onset Coronary Artery Stenosis
  • Mucopolysaccharidosis 4

    […] minimal to mild thickened mitral and/or aortic valve leaflets.[journals.plos.org] impairment Unlike some other types of MPS, Morquio syndrome doesn't appear to cause intellectual disabilities.[everydayhealth.com] impairment Deafness Hearing defect [ more ] 0000365 Hepatomegaly Enlarged liver 0002240 Hyperlordosis Prominent swayback 0003307 Hypoplasia of the odontoid process 0003311[rarediseases.info.nih.gov]

    Missing: Early-Onset Coronary Artery Stenosis
  • Menkes Disease

    In 70% of cases genetic testing of mother will show a mutation in the ATP7A gene Ultrasound may show bladder diverticula or "out pouching" in most cases Thickening of aortic[themenkesfoundation.org] […] vision Normal hearing The hair of individuals with Menkes syndrome deserves special discussion, particularly since this condition is sometimes also called kinky hair syndrome[encyclopedia.com] valve will occur in severe cases X-ray of skeleton/skull indicates wormian-twisted bones or metaphyseal widening[themenkesfoundation.org]

    Missing: Early-Onset Coronary Artery Stenosis

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