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465 Possible Causes for Early-Onset Obesity

  • Pseudohypoparathyroidism Type 1A

    CONTEXT: Pseudohypoparathyroidism type 1A (PHP1A) is caused by loss-of-function mutations on the maternally inherited GNAS allele and is associated with early-onset obesity[ncbi.nlm.nih.gov] CONTEXT: Patients with pseudohypoparathyroidism type 1a (PHP-1a) develop early-onset obesity.[ncbi.nlm.nih.gov] obesity.[ncbi.nlm.nih.gov]

  • ROHHAD Syndrome

    However, a limited number of cases, especially those with early-onset severe obesity, are linked to single gene defects.[ncbi.nlm.nih.gov] OBJECTIVE: To identify the underlying genetic etiology in a child with morbid early-onset obesity, hypoventilation, and autonomic and behavioral disturbances who was clinically[scholar.harvard.edu] To prevent presumptive mortality and morbidity, ROHHAD syndrome should be considered in all cases of rapid and early-onset obesity associated with hypothalamic-pituitary endocrine[journals.aace.com]

  • Obesity

    Thus, clinicians should search for monogenic obesity in patients with early-onset severe obesity and endocrinopathy.[ncbi.nlm.nih.gov] BACKGROUND: Recessive mutations in the leptin receptor (LEPR) are a rare cause of hyperphagia and severe early-onset obesity.[ncbi.nlm.nih.gov] […] the coding regions of the POMC gene for mutations in over 600 UK Caucasian subjects with severe early-onset obesity.[doi.org]

  • Metabolic Syndrome

    Alström syndrome is a rare autosomal recessive disorder characterized by retinal degeneration, sensorineural hearing loss, early-onset obesity, and non-insulin-dependent diabetes[ncbi.nlm.nih.gov] Krude, H, Biebermann, H, Luck, W, Horn, R, Brabant, G & Grueters, A ( 1998 ) Severe early-onset obesity adrenal insufficiency and red hair pigmentation caused by POMC mutations[doi.org] Alstrom syndrome (ALMS) is a very rare genetic autosomal recessive disease, characterized by early-onset severe abdominal obesity, impaired glucose tolerance or type 2 diabetes[ncbi.nlm.nih.gov]

  • Insulin Resistance

    Saltiel Nature Metabolism (2019) Heterozygous rare genetic variants in non-syndromic early-onset obesity Clara Serra-Juhé, Gabriel Á.[doi.org] Severe, early-onset insulin resistance in the absence of obesity, hepatic steatosis and dyslipidaemia is frequently attributable to a genetic defect affecting the insulin[ncbi.nlm.nih.gov] Congenital leptin deficiency is associated with severe early-onset obesity in humans.[doi.org]

  • Hypertension

    […] there is a positive family history of obesity in 1 or both parents; early onset of increasing weight beyond that appropriate for increase in height, which can be identified[doi.org] Observational studies have identified sample populations that are at special risk for obesity: children with a BMI between the 85th and 95th percentiles; children in whom[doi.org]

  • Hypogonadism

    Compared with late-onset T2DM, those with early-onset T2DM had a higher proportion of new-onset diabetes, were more likely to be obese, and had worse glycemic control, lipid[ncbi.nlm.nih.gov] The mean onset age was 29.86 6.31 and 54.47 9.97 years old in the early-onset group and late-onset group, respectively.[ncbi.nlm.nih.gov] The prevalence of hypogonadism was much higher in the early-onset group than in the late-onset group (48.0% vs. 26.7%, p 2017 American Society of Andrology and European Academy[ncbi.nlm.nih.gov]

  • Food Allergy

    Allen, The Role of Hypoallergenic Formula and Dietary Supplements in the Prevention of Early Onset Allergic Disease, Current Pediatrics Reports, 10.1007/s40124-016-0101-8,[doi.org] Nicola Principi and Susanna Esposito, Antibiotic administration and the development of obesity in children, International Journal of Antimicrobial Agents, 47, 3, (171), (2016[doi.org]

  • Morbid Obesity

    As the most commonly identified genetic cause of obesity, PWS is often confused with Early-onset Morbid Obesity (EMO).[clinicaltrials.gov] Obesity is an independent risk factor for infertility. Early onset of obesity in young women can result in irregular menstruation with erratic ovulation.[bariatrictimes.com] […] weight gain by women who are obese and pregnant results in increased adverse outcomes, such as fetal macrosomia and increased incidence of wound infection.[2,3] Impact of Obesity[bariatrictimes.com]

  • Bardet-Biedl Syndrome Type 11

    An autosomal recessive form of Bardet-Biedl syndrome (OMIM:209900), a genetically heterogeneous disorder characterised by usually severe pigmentary retinopathy, early-onset[medical-dictionary.thefreedictionary.com] […] association - COSMIC cancer census association via MalaCards Bardet-Biedl syndrome 1 (BBS1) [MIM:209900]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset[genecards.org] Disease description A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation[uniprot.org]

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