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561 Possible Causes for Early-Onset Osteoarthritis

  • Pseudoachondroplasia

    PSACH is a dominant condition characterized by disproportionate short stature, joint laxity, and early-onset osteoarthritis.[ncbi.nlm.nih.gov] osteoarthritis.[ncbi.nlm.nih.gov] Abstract We have identified a large family with a dominantly inherited chondrodysplasia characterized by a waddling gait, short limbs, and early onset osteoarthritis.[ncbi.nlm.nih.gov]

  • Multiple Epiphyseal Dysplasia

    PSACH is a dominant condition characterized by disproportionate short stature, joint laxity, and early-onset osteoarthritis.[ncbi.nlm.nih.gov] His height was 144.6 cm (20th percentile) and family history was notable for early-onset osteoarthritis in his father.[ncbi.nlm.nih.gov] The characteristic clinical findings are onset of symptoms in early childhood with predominance of knee and hip related complaints, normal stature, and early-onset osteoarthritis[ncbi.nlm.nih.gov]

  • Osteoarthritis

    This case highlights the potential benefit of surgical interventions including HTO in combination with MSC therapy in early-onset severe osteoarthritis.[ncbi.nlm.nih.gov] Mutations involving COL11A2 have been associated with severe and early-onset osteoarthritis.[emedicine.medscape.com]

  • Osteoporosis

    The main features of this autosomal inherited disease are ocular, auditory with orofacial abnormalities and early-onset osteoarthritis.[ncbi.nlm.nih.gov]

  • Stickler Syndrome

    onset severe osteoarthritis of the weight bearing joint.[ncbi.nlm.nih.gov] The main features of this autosomal inherited disease are ocular, auditory with orofacial abnormalities and early-onset osteoarthritis.[ncbi.nlm.nih.gov] Severe hearing loss with onset in early childhood may impair performance at school.[ncbi.nlm.nih.gov]

  • Gout

    Early-onset gout (onset before age 25, strong family history of gout and/or nephrolithiasis, and may be associated with genetic or enzymatic diseases of purine metabolism)[rheumatologyadvisor.com] These include: Gout in women (more likely to present with advanced disease, with tophi within Heberden’s nodes of osteoarthritis, and frequently flare in the context of diuretic[rheumatologyadvisor.com]

  • Torn Meniscus

    Because the meniscus acts as a shock absorber, loss of the normal function of the meniscus may lead to increased wear on the cartilage leading to early onset osteoarthritis[healthpages.org] This degenerative process is wear and tear which is really an early onset of osteoarthritis.[philly.com]

  • Ligament Tear

    It is important to note, that patients who chose not to have surgery and those who do undertake surgery both have an increased risk of developing early onset knee osteoarthritis[physioadvisor.com.au]

  • Spondyloepiphyseal Dysplasia

    It was also absent in 20 unrelated patients with chondrodysplasia and 30 unrelated patients with early-onset osteoarthritis.[ncbi.nlm.nih.gov] The proband is a member of a large Chilean kindred presenting with chondrodysplasia of the hips, knees, shoulders, elbows, and spine associated with severe, early-onset osteoarthritis[ncbi.nlm.nih.gov] Abstract Spondyloepiphyseal dysplasia tarda (SEDL) is a genetically heterogeneous disorder characterized by mild-to-moderate short stature and early-onset osteoarthritis.[ncbi.nlm.nih.gov]

  • Pseudogout

    "Linkage of early-onset osteoarthritis and chondrocalcinosis to human chromosome 8q". Am. J. Hum. Genet. 56 (3): 692–7. PMC 1801178. PMID 7887424. Arend CF.[en.wikipedia.org] onset osteoarthritis, 8 and it has recently been associated with chromosome 15. 14 The pathogenesis of calcium pyrophosphate dihydrate crystal deposition is not fully understood[nature.com] Linkage of early-onset osteoarthritis and chondrocalcinosis to human chromosome 8q. Am J Hum Genet. 1995;56:692–7. PubMed Google Scholar 7. Andrew LJ, Brancolini V.[doi.org]

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