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11 Possible Causes for Early Onset Puberty, Fever of Unknown Origin, Increased Sweating

  • Fabry Disease

    KEYWORDS: Algorithm; Diagnosis; FUO; Fabry disease; Fever of unknown origin; RFUO; Rare diseases; Recommendations; Recurrent fever of unknown origin[] The number and size of these lesions progressively increase with age.[] Often patients have slight builds with characteristic coarse facial features and delayed puberty.[]

  • Inflammatory Bowel Disease Type 1

    Delayed growth and onset of puberty (looking younger than your peers) will have a significant negative impact on the child's psychosocial development and self‐image.[] The transition from early (dependent on parents) to late adolescence (dependent on self) can be particularly difficult for a child with chronically active IBD.[]

  • Autosomal Recessive Pachydermoperiostosis 

    There was a history of delayed closure of the fontanelles, recurrent periods of fever of unknown origin and vomiting in the first 3 years.[] The presentation at a community clinic with a gradual onset of increased size of hands and feet, facial coarsening, increased sweating and seborrhea led to a referral to a[] The onset of PHO is usually before the age of 20, but its biphasic incidence is now attributed to the genetic heterogeneity, with onset of symptoms in early childhood for[]

  • Suprasellar Tumor

    Pituitary lymphoma presenting as fever of unknown origin. J Clin Endocrinol Metab 2001 ; 86 : 1470 –1476 Erdag N, Bhorade RM, Alberico RA, Yousuf N, Patel M.[] Thickening of skin Increased mortality in patients more than 45 years of age Congestive heart failure Hypertension Lethargy and weight gain Organomegaly Liver Heart Kidney[] The high testosterone level in males inducing early onset of puberty, can be due to increased β-hCG.[]

  • ROHHAD Syndrome

    This fever of unknown cause was thought to be of central origin.[] Rapid weight gain, obesity, alveolar hypoventilation, hypernatremia, cardiopulmonary arrest, hyperprolactinemia, diabetes insipidus, excessive sweating, increase pain perception[] Symptoms related to hypothalamic dysfunction may include abnormal sodium balance ( hyponatremia or hypernatremia ), high progestin levels, low cortisol levels, delayed or early-onset[]

  • Childhood Schizophrenia

    Holmes and Discussant: Barbara Coffey, Worsening Psychosis after Fever of Unknown Origin in an Adolescent Boy with Autism, Journal of Child and Adolescent Psychopharmacology[] (M‐H, Fixed, 95% CI) 6.0 [1.09, 33.02] 6.2 Anticholinergic—sweating 1 39 Odds Ratio (M‐H, Fixed, 95% CI) 9.5 [1.69, 53.33] 6.3 Central nervous system—drowsiness 1 39 Odds[] For those who might develop psychotic disorders or schizophrenia as adults (adult-onset), it is not uncommon for them to start experiencing early warning signs during puberty[]

  • Familial Congenital Nasolacrimal Duct Obstruction

    Fever of Unknown Origin Fibroadenoma Fibrocystic Disease of Breast Fibroma Fibroma, Desmoplastic Fibroma, Ossifying Fibromatosis, Abdominal Fibromatosis, Aggressive Fibromatosis[] […] chloride test (increased chloride in sweat) or genetic tests performed at 6 – 10 weeks age Treatment: Best: Respiratory: Chest physiotherapy, mucolytics, infection control[] […] sexual development Findings during adolescence – Late onset of puberty – Slow growth and short stature – Delay in eruption of teeth and in shedding primary teeth – Infrequent[]

  • Autoinflammatory Syndrome

    Many rheumatic disorders that are considered when evaluating for a cause of fever of unknown origin are defined by aberrations of the adaptive or acquired immune system.[] Despite maintenance of anakinra, some of her symptoms increased in severity, with increased frequency of episodic night sweats, aphthous ulceration, and a pruritic skin rash[] Other complications vary in severity and age of onset, but include: Early growth retardation, delayed puberty Skull abnormalities, frontal bossing Progressive profound sensorineural[]

  • Neonatal Inflammatory Skin and Bowel Disease

    Syndromes; Primary and Secondary Causes of Autonomic Dysfunction; Usual and Unusual Manifestations of Systemic and CNS Vasculitis; Fever of Unknown Origin; Differentiating[] Neonatal intestinal obstruction (meconium ileus)/ Nasal polyps Clubbing of fingers/ Chest radiograph with characteristic changes Rectal prolapse Electrolyte elevation in sweat[] Jaw growth stabilizes during puberty, and facial features improve and are normal in most adults with the disease. [113] Can affect the development of the teeth.[]

  • Adrenal Cortex Tumor

    However, a survey of the large series of fever of unknown origin revealed no mention of adrenal tumors in that group of solid tumors which many cause prolonged fever. 1988[] Several signs and symptoms may be seen, including: Bruising High blood pressure Weakness High blood sugar levels or diabetes Low potassium levels Excessive hair growth Sweating[] Symptoms of androgen-producing tumors in boys include the early onset of puberty.[]