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57 Possible Causes for Early Onset Puberty, Glucose Tolerance Test Abnormal

  • Insulin Resistance

    Early onset of reproductive function in normal female mice treated with leptin. Science 275, 88–90 (1997). 27 Montague, C. T. et al.[doi.org] In addition, an oral glucose tolerance test (OGTT) can be used to detect insulin resistance and is more sensitive for detecting milder/earlier disease.[emedicinehealth.com] An oral glucose tolerance test (OGTT) may be normal or mildly abnormal in simple insulin resistance.[en.wikipedia.org]

  • Obesity

    Upon resolution of the joint symptoms, the aspirin was discontinued, and a repeat glucose tolerance test was grossly abnormal.[ncbi.nlm.nih.gov] The administration of leptin permitted progression of appropriately timed pubertal development in the single child of appropriate age and did not cause the early onset of[doi.org] Fasting and postchallenge glucose concentrations were nearly normal, despite the discontinuation of insulin and treatment with aspirin alone.[ncbi.nlm.nih.gov]

  • Polycystic Ovary Syndrome

    Once the diagnosis was made, she was screened for lipid abnormalities and for glucose intolerance.[ncbi.nlm.nih.gov] Fewer menstrual cycles in early puberty can translate into less estrogen to develop mammary tissue.[mobimotherhood.org] tolerance test, with referral to a specialist obstetric diabetic service if abnormalities are detected.[patient.info]

  • Familial Partial Lipodystrophy

    If the test result is 'positive' (please describe): A regular clinical and biological follow-up of the person is required, including screening for glucose tolerance abnormalities[nature.com] A wide clinical spectrum of muscular features might be encountered, ranging from invalidating myopathy of early disclosure to mild delayed-onset muscular dystrophy.[academic.oup.com] […] tested person is clinically unaffected but carries an increased risk based on family history (To be answered if in 1.9 'B' was marked). 3.2.1 Will the result of a genetic test[nature.com]

  • Cushing's Disease

    Early onset of puberty has been reported after whole-brain irradiation for childhood leukemias ( 31 ).[doi.org] Gonadotropin secretion may be disturbed after whole-brain or pituitary irradiation, puberty being either early or delayed.[doi.org] With the exception of early puberty in one of our patients ( 20 ), no abnormalities of gonadal function were observed.[doi.org]

  • Primrose Syndrome

    Premature (early onset) menopause is when periods stop before the age of 40 years. Why does menopause occur?[southerncross.co.nz] At puberty, hormones produced by the pituitary gland in the brain stimulate the ovaries to begin releasing eggs each month (ovulation).[southerncross.co.nz]

  • Diabetes Mellitus

    Type 1 DM usually starts in children aged 4 years or older, appearing fairly abruptly, with the peak incidence of onset at age 11-13 years (ie, in early adolescence and puberty[emedicine.com] At age 17 months hypoglycemic seizures occured (blood glucose 5 mg/100 ml). An oral glucose tolerance test was abnormal.[pediatrics.aappublications.org] If the 1-hour test is abnormal, you will have a second glucose tolerance test done to confirm the diagnosis.[stanfordchildrens.org]

  • Klinefelter Syndrome

    Testosterone replacement therapy: Since males with Klinefelter syndrome don't produce enough testosterone, undergoing testosterone replacement therapy at the onset of puberty[everydayhealth.com] Abnormal glucose tolerance test (GTT) results and diabetes mellitus are more frequent among Klinefelter syndrome patients and their parents than in the general population.[glowm.com] […] apoptosis instead of entering meiosis at the onset of puberty.[web.archive.org]

  • Diabetes Mellitus Type 1

    If the result is abnormal, the fasting plasma glucose test may be repeated on a different day to confirm the result.[emedicinehealth.com] Type 1 DM usually starts in children aged 4 years or older, appearing fairly abruptly, with the peak incidence of onset at age 11-13 years (ie, in early adolescence and puberty[emedicine.medscape.com] Or the patient may undergo an oral glucose tolerance test or a glycosylated hemoglobin test (often called " hemoglobin A1c ") as a confirmatory test.[emedicinehealth.com]

  • Adrenal Cortical Adenoma

    : early onset development of appropriate sexual characteristics for a patient’s sex (in women due to increased estrogen, in men due to increased androgens) ACT in the context[pathologyoutlines.com] We describe a case of Cushing syndrome in pregnancy secondary to an adrenal cortical tumour which was discovered after an abnormal glucose tolerance test.[ncbi.nlm.nih.gov] […] acne, male musculature, clitoromegaly Feminization: occurs in men due to estrogen excess Gynecomastia, testicular atrophy, impotence, diminished libido Isosexual precocious puberty[pathologyoutlines.com]

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