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156 Possible Causes for Early Onset Puberty, Hirsutism, X-Ray Abnormal

  • Porphyria

    Clinical onset usually occurs in infancy or in early childhood, but very rare cases of onset at puberty or later have been reported. [31] Hemolysis may be a feature in homozygous[emedicine.medscape.com] Most of the time the facial hairs are fine, so the hirsutism is barely noticeable.[web.archive.org]

  • Adrenal Gland Neoplasm

    In females, this can cause deepening of the voice, increased hair growth (i.e. hirsutism), acne, and ambiguous genitalia.[columbiasurgery.org] Symptoms of androgen-producing tumors in boys include the early onset of puberty.[nyulangone.org] Most patients present with features of glucocorticoid excess (Cushing's syndrome), which includes central obesity, peripheral weakness, abdominal striae, buffalo hump, hirsutism[surgwiki.com]

  • Anorexia Nervosa

    Common physical findings include bradycardia, low BP, hypothermia, lanugo hair or slight hirsutism, and edema. Body fat is greatly reduced.[msdmanuals.com] […] as age 8 and as late as middle age, but its onset is most common around or just after puberty.[emilyprogram.com] The onset is typically at or around puberty, although anorexia can also start as early as age 8 and in middle age.[remudaranch.com]

  • Osteoporosis

    If the VFA results reveal suspected abnormalities, plain x-rays should be done to confirm the diagnosis.[merckmanuals.com] The deficiency can be the result of late onset of puberty/getting their period, early menopause (before 40), or an absence or suppression of menstruation.[umms.org] […] fractures, Wormian bones, failure of suture ossification, basilar impression, vertebral abnormalities, joint laxity, bowed fibulae, short distal digits, acroosteolysis, and hirsutism[web.archive.org]

  • Diabetes Mellitus

    Type 1 DM usually starts in children aged 4 years or older, appearing fairly abruptly, with the peak incidence of onset at age 11-13 years (ie, in early adolescence and puberty[emedicine.medscape.com] A 16-year-old female with CHI due to a dominant ABCC8 gene mutation was switched from diazoxide therapy to sirolimus, due to the hypertrichosis side effect of diazoxide.[ncbi.nlm.nih.gov]

  • Lytic Bone Lesion

    Osteoporosis can be diagnosed using a test called a bone density X-ray, which uses x-rays to look at the bone strength.[diseaseinfosearch.org] Type VIII First described by Stewart and others in 1977, 12 type VIII is characterized by generalized early-onset periodontitis and by large patches of scar tissue on the[cda-adc.ca] SFPKS was first described in a 5-year-old female with a distinct facial appearance, proportional short stature, hirsutism, polycystic kidneys, vertebral abnormalities, elongated[nature.com]

  • McCune-Albright Syndrome

    The pattern of terminal hair on the skin following the administration of the drug and the exclusion of other causes suggested tamoxifen-induced hirsutism.[ncbi.nlm.nih.gov] Individuals with MAS often experience an abnormally early onset of puberty (gonadotropin independent precocious puberty).[rarediseases.org] Bone abnormalities (fibrous dysplasia) are sometimes removed with surgery. Limit the number of x-rays taken of affected areas of the body.[ufhealth.org]

  • Cushing's Disease

    […] to measure for corticosteroid hormones Computed tomography (CT or CAT scan) – to detect any abnormalities that may not show up on an ordinary x-ray Magnetic resonance imaging[hopkinsmedicine.org] Early onset of puberty has been reported after whole-brain irradiation for childhood leukemias ( 31 ).[doi.org] The clinical signs suggesting Cushing's disease, such as obesity, moon face, hirsutism, and facial plethora are already present on presentation.[ncbi.nlm.nih.gov]

  • Familial Partial Lipodystrophy

    Abdominal USG examination revealed features of hepatic steatosis ; chest X-ray and echocardiogram showed no abnormalities.[omicsonline.org] A wide clinical spectrum of muscular features might be encountered, ranging from invalidating myopathy of early disclosure to mild delayed-onset muscular dystrophy.[academic.oup.com] She also had hirsutism.[ncbi.nlm.nih.gov]

  • Donohue Syndrome

    Clinical examinations for whole body systems were performed: chest X-Rays, cranial ultrasound, and heart echocardiogram which were all intact.[journals.lww.com] Early onset of puberty Early puberty [ more ] 0000826 Recurrent infections Frequent infections Frequent, severe infections Increased frequency of infection infections, recurrent[rarediseases.info.nih.gov] […] a rare and lethal autosomal recessive disease caused by mutations in the insulin receptor (INSR) gene, manifesting marked insulin resistance, severe growth retardation, hypertrichosis[ncbi.nlm.nih.gov]

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