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21 Possible Causes for Early Onset Puberty, Pediatric Disorder, Quadriceps Muscle Weakness

  • Diabetes Mellitus Type 1

    Adult and pediatric endocrinologists, specialists in treating hormonal disorders and disorders of the endocrine system, manage patients with diabetes.[medicinenet.com] Type 1 DM usually starts in children aged 4 years or older, appearing fairly abruptly, with the peak incidence of onset at age 11-13 years (ie, in early adolescence and puberty[emedicine.medscape.com] […] diseases of the endocrine system, such as diabetes and growth disorders.[kidshealth.org]

  • Anorexia Nervosa

    Identifying and treating eating disorders. Pediatrics. 2003;111:204-11. ).[acphospitalist.org] […] as age 8 and as late as middle age, but its onset is most common around or just after puberty.[emilyprogram.com] The onset is typically at or around puberty, although anorexia can also start as early as age 8 and in middle age.[remudaranch.com]

  • Tay-Sachs Disease

    Bone marrow transplantation in children with hereditary disorders [review]. Curr Opin Pediatr. 1996; 8 :42–44. [ PubMed ] [ Google Scholar ] 25.[ncbi.nlm.nih.gov] It causes death early in childhood. Late-onset Tay-Sachs can start between puberty and the mid-30s. How long a person lives depends on how severe the symptoms are.[myhealth.alberta.ca] Leg weakness was noted in all patients, especially in the iliopsoas and quadriceps muscles.[nature.com]

  • Cushing's Disease

    Nieman, Cushing’s Syndrome, Endocrinology: Adult and Pediatric, 10.1016/B978-0-323-18907-1.00013-5, (227-255.e11), (2016). M.G. Baroni, F. Giorgino, V. Pezzino, C.[doi.org] Early onset of puberty has been reported after whole-brain irradiation for childhood leukemias ( 31 ).[doi.org] Ludlam, Economic burden of multiple chronic comorbidities associated with Cushing’s disease, a rare endocrine disorder, Expert Opinion on Orphan Drugs, 4, 3, (291), (2016)[doi.org]

  • ROHHAD Syndrome

    Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) falls within a group of pediatric disorders with both respiratory[ncbi.nlm.nih.gov] Symptoms related to hypothalamic dysfunction may include abnormal sodium balance ( hyponatremia or hypernatremia ), high progestin levels, low cortisol levels, delayed or early-onset[en.wikipedia.org] If your quadriceps are weak, you’re more likely to have irritated plicae.[healthline.com]

  • Diabetic Autonomic Neuropathy

    HLA-partially Matched Family Donor After Negative Selection of TCR αβ T Cells in Pediatric Patients Affected by Hematological Disorders Active, not recruiting NCT02065869[malacards.org] Type 1 DM usually starts in children aged 4 years or older, appearing fairly abruptly, with the peak incidence of onset at age 11-13 years (ie, in early adolescence and puberty[emedicine.medscape.com] Bilateral thigh pain or weakness with atrophy of the iliopsoas, quadriceps, and adductor muscles also may be present.[aafp.org]

  • Breast Hamartoma

    The thoroughly updated Fourth Edition of this acclaimed reference describes and illustrates the full range of pediatric disorders diagnosable by modern neuroimaging.[books.google.ro] onset of puberty.[en.wikipedia.org] The left thigh examination showed a diffuse swelling with an old healed longitudinal scar over the anterolateral aspect of the left thigh and wasting of the quadriceps muscles[webmedcentral.com]

  • Roaf's Syndrome

    The onset of the condition is often around puberty. Vision becomes affected when the coning leads to increased astigmatism.[cardiff.ac.uk] Often ITB syndrome is caused by a muscle imbalance, where some muscle groups (hip flexors, quadriceps) have become too tight, while others (hip abductors and extensors) have[cyclingweekly.com] In the early stages glasses can be used to correct vision. In more advanced cases hard (Gas Permeable) contact lenses are the preferred treatment.[cardiff.ac.uk]

  • Ataxia

    Our program excels in this respect, as each of our physicians has specialized expertise in diagnosing and treating various adult and pediatric cerebellar disorders.[massgeneral.org] Clinical features Early onset progressive ataxia Short stature Hypodontia Delayed puberty secondary to gonadal dysfunction Laboratory MRI shows white matter signal abnormalities[emedicine.medscape.com] Weakness of the quadriceps muscles will cause the patient to swing the affected leg forward and lock the knee at the time of heel-strike in order to prevent the leg from collapsing[dartmouth.edu]

  • Spastic Ataxia with Congenital Miosis

    Disorders E-2903 168 Measurement of Health Outcomes in Pediatric Neurologic Disorders E-2910 169 The Influence of Computer Resources on Child Neurology E-2918 170 Education[books.google.com] Clinical features Early onset progressive ataxia Short stature Hypodontia Delayed puberty secondary to gonadal dysfunction Laboratory MRI shows white matter signal abnormalities[emedicine.medscape.com] Foot drop from tibialis anterior weakness, inability to walk on the toes from gastrocnemius and soleus weakness, instability at the knee from quadriceps weakness or weakness[casemed.case.edu]