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190 Possible Causes for Early-Onset Severe Obesity

  • Obesity

    Thus, clinicians should search for monogenic obesity in patients with early-onset severe obesity and endocrinopathy.[ncbi.nlm.nih.gov] BACKGROUND: Recessive mutations in the leptin receptor (LEPR) are a rare cause of hyperphagia and severe early-onset obesity.[ncbi.nlm.nih.gov] […] the coding regions of the POMC gene for mutations in over 600 UK Caucasian subjects with severe early-onset obesity.[doi.org]

  • Metabolic Syndrome

    Alstrom syndrome (ALMS) is a very rare genetic autosomal recessive disease, characterized by early-onset severe abdominal obesity, impaired glucose tolerance or type 2 diabetes[ncbi.nlm.nih.gov] early-onset obesity in humans.[doi.org] In this experiment the ob/ob animals developed early onset and severe obesity regardless of TNFR allele they carried.[doi.org]

  • Insulin Resistance

    Severe, early-onset insulin resistance in the absence of obesity, hepatic steatosis and dyslipidaemia is frequently attributable to a genetic defect affecting the insulin[ncbi.nlm.nih.gov] Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903– 908 (1997). 14 Pelleymounter, M. A. et al.[doi.org] Congenital leptin deficiency is associated with severe early-onset obesity in humans.[doi.org]

  • Diabetic Nephropathy

    Additionally, several common susceptibility variants associated with early-onset obesity, polygenic type 2 diabetes and nephropathy were identified in the proband that could[ncbi.nlm.nih.gov] […] impose additional effects on the phenotype, its severity or its clinical course.[ncbi.nlm.nih.gov]

  • Osteoarthritis of the Knee

    And while the majority of people will suffer from cartilage degeneration at some point in their life, certain lifestyle decisions may trigger an early onset of OA of the knee[symptoma.com] […] or more severe symptoms.[symptoma.com] In this context, overweight and obesity are the main risk factors. Also, certain activities involving heavy knee loads may exacerbate cartilage damage.[symptoma.com]

  • Preeclampsia

    (b) Moderate risk: defined as none of the above, but having either previous pre‐eclampsia that was not severe or early onset (or severity unspecified), or a first pregnancy[doi.org] […] and at least one of the following: teenager or over 35 years age, family history of pre‐eclampsia, obesity (body mass index of at least 30), increased sensitivity to Angiotensin[doi.org] […] and at least one of the following: teenager or over 35 years age, family history of pre‐eclampsia, obesity (body mass index greater than or equal to 30), increased sensitivity[doi.org]

  • ROHHAD Syndrome

    However, a limited number of cases, especially those with early-onset severe obesity, are linked to single gene defects.[ncbi.nlm.nih.gov] CONCLUSIONS: This study identifies a de novo RAI1 mutation in a child with morbid obesity and a clinical diagnosis of ROHHAD syndrome.[scholar.harvard.edu] Meghan C Towne, Catherine A Brownstein, Philip M James, Laura Crowley, Joel N Hirschhorn, Sarah H Elsea, Alan H Beggs, Jonathan Picker, Pankaj B Agrawal CONTEXT: The current obesity[read.qxmd.com]

  • Pancreatic Neoplasm

    For example, Li et al found that being overweight or obese during early adulthood was associated with a greater risk of pancreatic cancer and a younger age of disease onset[emedicine.com] , while obesity at an older age was associated with lower overall survival. [15] Several other studies have supported a link between early obesity and the risk of pancreatic[emedicine.com]

  • Malignant Melanoma

    Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genet. 19, 155–157 (1998). 31. Eller, M.[nature.com] Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans . Nature Genet. 19 , 155–157 (1998). 31. Eller, M.[nature.com]

  • Benign Familial Infantile Epilepsy Type 4

    Bochukova EG, Huang N, Keogh J, Henning E, Purmann C, et al. (2010) Large, rare chromosomal deletions associated with severe early-onset obesity. Nature 463: 666–670.[journals.plos.org]

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