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72 Possible Causes for Early Onset Severe Renal Disease

  • Preeclampsia

    disease, thrombophilia, autoimmune disease, previous severe or early onset pre‐eclampsia, or multiple pregnancy.[doi.org] […] grouped on the basis of their risk at trial entry as follows. (1) Women with normal blood pressure (a) High risk: defined as having one or more of the following: diabetes, renal[doi.org] (a) High risk: defined as having one or more of the following: diabetes, renal disease, thrombophilia, autoimmune disease, or previous severe or early onset pre‐eclampsia[doi.org]

  • Influenza Pneumonia

    Clinical Outcomes In mild to moderate uncomplicated disease, the reported benefits of early treatment ( 48 h of symptom onset) with NI have been a shorter duration and severity[link.springer.com] Rimantadine is extensively metabolized in the liver, and dose reduction is recommended for patients with severe hepatic dysfunction, renal failure (creatinine clearance 45[link.springer.com]

  • Fabry Disease

    Indeed, in the present study severe manifestations of disease were common, with 77% of women reporting neurological involvement, 59% cardiac involvement, and 40% renal involvement[ncbi.nlm.nih.gov] Although the onset of symptoms was not as early as is typically observed in males, the majority of signs and symptoms assessed had developed by the third and fourth decades[ncbi.nlm.nih.gov] […] et al 4 and Whybra et al 7 that the majority of females who are heterozygous for disease causing mutations in the α‐galactosidase A gene report clinical features of Fabry disease[ncbi.nlm.nih.gov]

  • Congenital Nephrotic Syndrome

    It is characterized by early onset and progresses to end-stage renal disease.[ncbi.nlm.nih.gov] Recently, several genes associated with CNS have been identified, including NPHS1 and NPHS2.[ncbi.nlm.nih.gov]

  • Granulomatosis with Polyangiitis

    Consensus does not exist as to whether limited GPA represents early severe disease or an altogether separate clinical entity.[emedicine.medscape.com] The terminology, limited versus severe, can sometimes be problematic because pulmonary and/or renal involvement may be absent at the onset of symptoms.[emedicine.medscape.com]

  • Neonatal Severe Primary Hyperparathyroidism

    Disease severity depends on the degree of gain of function, spanning the spectrum from mild hypoparathyroidism, which is diagnosed incidentally, to severe and early onset[mayomedicallaboratories.com] disease.[mayomedicallaboratories.com] […] addition, while the majority of patients suffer only from hypoparathyroidism, a small subgroup with extreme gain of function mutations suffer from concomitant inhibition of renal[mayomedicallaboratories.com]

  • Familial Hypocalciuric Hypercalcemia Type 2

    Disease severity depends on the degree of gain of function, spanning the spectrum from mild hypoparathyroidism, which is diagnosed incidentally, to severe and early onset[mayomedicallaboratories.com] disease.[mayomedicallaboratories.com] […] addition, while the majority of patients suffer only from hypoparathyroidism, a small subgroup with extreme gain of function mutations suffer from concomitant inhibition of renal[mayomedicallaboratories.com]

  • Familial Hypocalciuric Hypercalcemia Type 3

    Disease severity depends on the degree of gain of function, spanning the spectrum from mild hypoparathyroidism, which is diagnosed incidentally, to severe and early onset[mayomedicallaboratories.com] disease.[mayomedicallaboratories.com] […] addition, while the majority of patients suffer only from hypoparathyroidism, a small subgroup with extreme gain of function mutations suffer from concomitant inhibition of renal[mayomedicallaboratories.com]

  • Microscopic Polyangiitis

    Arthralgias/myalgias (50%) and severe abdominal pain often herald disease onset.[rheumaknowledgy.com] Cardinal Findings: Significant constitutional symptoms may predominate early and include fever, weight loss, and severe malaise.[rheumaknowledgy.com] In PAN, visceral organ manifestations (in order of decreasing frequency) include (Fig. 7): —Renal (70%–80%): Impaired renal function, proteinuria, and hypertension are secondary[rheumaknowledgy.com]

  • Meckel Syndrome Type 7

    Disease description A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation[uniprot.org] […] pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation.[genecards.org] Secondary features include diabetes mellitus, hypertension and congenital heart disease.[uniprot.org]

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