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1,780 Possible Causes for Easy Bruising, Leukocyte Alkaline Phosphatase Increased, Wide Space Between the First and Second Toe

  • Down Syndrome

    Parents of infants with TMD should be counseled regarding the risk of leukemia and made aware of the signs, including easy bruising, petechiae, onset of lethargy, or change[dx.doi.org] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] spacing, often with a deep plantar groove between the first and second toes.[dx.doi.org]

  • Portal Cirrhosis

    Cirrhosis can lead to Easy bruising or bleeding, or nosebleeds Swelling of the abdomen or legs Extra sensitivity to medicines High blood pressure in the vein entering the[medlineplus.gov]

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  • Myeloproliferative Disease

    A myeloproliferative disorder manifested by thrombocytosis, a high leukocyte alkaline phosphatase (LAP) score and an increased red blood cell mass was found in a 64-yr-old[ncbi.nlm.nih.gov] Most common in chronic myelogenous leukemia and agnogenic myeloid metaplasia Easy bruising, bleeding, and/or symptoms of thrombosis Swollen, painful joint(s) secondary to[emedicine.com] Leukocyte alkaline phosphatase ( 100 units in the absence of fever or infection). There is no staging system for this disease.[northshore.org]

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  • Aplastic Anemia

    Symptoms include: Bleeding gums Easy bruising Nose bleeds Rash, small pinpoint red marks on the skin (petechiae) Frequent or severe infections (less common) Mild cases of[nlm.nih.gov] Low platelet counts can result in easy bruising or bleeding. Some people with aplastic anemia show no symptoms at all.[froedtert.com]

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  • Leukoerythroblastic Anemia

    leukocyte alkaline phosphatase: 100 score; increased vitmain B12 900 pg/mL or B12 binding protein 2200 pg/mL Treatment of polycythemia vera phlebotomy to reduce hyperviscosity[memorize.com] The anemia causes fatigue, weakness, and paleness; the leukopenia causes increased susceptibility to infection; the thrombocytopenia causes easy bruising and bleeding.[proz.com] Severe anemia, easy bruising or bleeding, and multiple infections can result because of the lack of healthy blood cells.[oncolink.org]

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  • Macronodular Cirrhosis

    Cirrhosis can lead to Easy bruising or bleeding, or nosebleeds Swelling of the abdomen or legs Extra sensitivity to medicines High blood pressure in the vein entering the[icdlist.com] Anorexia, early satiety, dyspepsia, altered bowel habits, and easy bruising and bleeding also are reported often.[medical-dictionary.thefreedictionary.com] As the disease progresses, manifestations such as chronic dyspepsia, constipation, anorexia, weight loss, pruritus, easy bruising, bleeding gums, nosebleeds, upper gastrointestinal[medical-dictionary.thefreedictionary.com]

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  • Myelodysplasia

    If you have symptoms, they may include Shortness of breath Weakness or feeling tired Skin that is paler than usual Easy bruising or bleeding Pinpoint spots under the skin[medlineplus.gov] The resulting deficiencies of platelets and red and white blood cells cause anemia, susceptibility to infections, and easy bruising and bleeding.[clinicaltrials.gov]

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  • Primary Myelofibrosis

    alkaline phosphatase (LAP) score is increased Treatment Reduced intensity allogeneic stem cell transplant if intermediate to high risk or palliation of extramedullary hematopoiesis[pathologyoutlines.com] Easy bruising or bleeding. Petechiae (flat, red, pinpoint spots under the skin that are caused by bleeding). Fever. Night sweats. Weight loss.[navigatingcare.com] bruising Persistent bleeding Presence of kidney stones Fever Night sweats Bone pain Pale appearance (pallor) How is Primary Myelofibrosis Diagnosed?[dovemed.com]

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  • Liver Failure

    Kidney disease or failure Easy bruising and severe bleeding. This happens when the liver stops making proteins that are needed for your blood to clot. Type 2 diabetes.[hopkinsmedicine.org] bruising and abnormal bleeding Confusion or problems thinking Pale or clay-colored stools Your health care provider will do a physical exam to look for: An enlarged liver[medlineplus.gov] bruising Spider-like veins in the skin Low energy and weakness (fatigue) Weight loss Confusion as toxins build up in the blood The symptoms of cirrhosis may look like other[hopkinsmedicine.org]

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  • Polycythemia Vera

    leukocyte alkaline phosphatase , increased vit.B12 level, decreased folic acid level, elevated alk.phosphatase & conjungated bilirubin, hypercalcemia.[enotes.tripod.com] Some patients with PV will not demonstrate any symptoms at all, but many will experience easy bruising or bleeding with little or no injury.[uihc.org] Individuals, who demonstrate signs and symptoms, have the following: Trouble breathing, feeling weak and tired Easy bruising and bleeding Severe, throbbing headache Skin appears[dovemed.com]

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