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355 Possible Causes for Easy Bruising, Pallor, Splenomegaly

  • Hereditary Spherocytosis

    Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[ncbi.nlm.nih.gov] Incidentally, the parents provided a history of repeated episodes of pallor and jaundice since she was two and half years old.[ncbi.nlm.nih.gov] He had been suffering from repeated attacks of jaundice, pallor, and splenomegaly since he was 10 years old.[ncbi.nlm.nih.gov]

  • Leukemia

    Acute leukemia usually develops quickly and tends to cause fatigue, easy bruising, and frequent infections.[uabmedicine.org] Five features were present in 50% of children: hepatomegaly (64%), splenomegaly (61%), pallor (54%), fever (53%) and bruising (52%).[ncbi.nlm.nih.gov] bruising or bleeding (due to low blood platelet counts) and fatigue (due to low red blood cell counts).[cancersupportcommunity.org]

  • Myeloproliferative Disease

    Most common in chronic myelogenous leukemia and agnogenic myeloid metaplasia Easy bruising, bleeding, and/or symptoms of thrombosis Swollen, painful joint(s) secondary to[emedicine.com] CML: demonstrates increased production of neutrophils and marked splenomegaly.[ncbi.nlm.nih.gov] The unusual case of myeloproliferative disease described here is characterized by the following features: (1) a clinically completely silent course for 11 years without splenomegaly[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    Easy bruising or bleeding. Petechiae (flat, red, pinpoint spots under the skin that are caused by bleeding). Fever. Night sweats. Weight loss.[navigatingcare.com] We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net]

  • Myelodysplasia

    Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which[ncbi.nlm.nih.gov] If you have symptoms, they may include Shortness of breath Weakness or feeling tired Skin that is paler than usual Easy bruising or bleeding Pinpoint spots under the skin[medlineplus.gov] Symptoms are referable to the specific cell line most affected and may include fatigue, weakness, pallor (secondary to anemia), increased infections and fever (secondary to[msdmanuals.com]

  • Gaucher Disease

    Gaucher Disease [GBA]: Enlargement of spleen and liver, blood abnormalities (anemia, easy bruising, impaired clotting, etc), and bone problems (joint pain, bone fractures,[jewishgeneticdiseases.org] CONCLUSION: HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands.[ncbi.nlm.nih.gov] […] reactions, occurring in 2 or more patients, included abdominal pain, agitation, fever, chills, diarrhea, eczema, edema, hypertension, irritability, laryngeal edema, nausea, pallor[aetna.com]

  • Childhood Acute Lymphoblastic Leukemia

    Signs and symptoms may include fever; easy bruising or bleeding; bone or joint pain; painless lumps in the neck, underarm, stomach, or groin; weakness; fatigue; and/or loss[rarediseases.info.nih.gov] The child redeveloped splenomegaly and fever, and then suffered an acute decompensation with hypoxemia, tachypnea, splenomegaly, and cardiac gallop.[ncbi.nlm.nih.gov] Anemia may manifest as pallor, headache, fatigue, dizziness, decreased energy or exercise tolerance, and sometimes syncope.[clinicaladvisor.com]

  • Rheumatoid Arthritis

    Steroids do have side effects, such as easy bruising, bone thinning, cataracts, and diabetes. Anti-rheumatic medicines can help treat RA.[familydoctor.org] It is extremely rare for RA to present as FS or develop after initially presenting as neutropaenia and splenomegaly.[ncbi.nlm.nih.gov] bruising, muscle weakness and thinning of the skin.[nhsinform.scot]

  • Chronic Myeloid Leukemia

    It can lead to easy bruising or bleeding, with frequent or severe nosebleeds and bleeding gums. Some patients with CML actually have too many platelets (thrombocytosis).[cancer.org] Three of 4 TKI-treated patients did not reach complete hematologic response due to the persistence of thrombocytosis and/or splenomegaly.[ncbi.nlm.nih.gov] […] insidious, with a nonspecific “benign” stage (malaise, anorexia, weight loss) eventually giving way to accelerated or blast phases with more ominous signs, such as splenomegaly, pallor[msdmanuals.com]

  • Polycythemia Vera

    Some patients with PV will not demonstrate any symptoms at all, but many will experience easy bruising or bleeding with little or no injury.[uihc.org] […] symptoms in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[ncbi.nlm.nih.gov] The symptoms are burning pain in the feet, hands, toes and fingers, sometimes associated with pallor, erythema, or cyanosis. Occasionally, it progresses to gangrene.[symptoma.com]

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