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164 Possible Causes for Easy Bruising, Progressive Polyneuropathy, Ulcer

  • Vasculitis

    Neuropathy Sensory or Sensory-Motor General patterns Mononeuritis multiplex (13%) Asymmetric polyneuropathy (85%) Distal symmetric polyneuropathy (2%) More slowly progressive[neuromuscular.wustl.edu] ., palpable purpura, vasculitic urticaria, nodules, ulcers, mouth ulcers. Neurologic signs: e.g., headache, mononeuritis multiplex, focal neurological lesions (stroke).[pmmonline.org] Inflammatory disease (15-20%) - eg, systemic lupus erythematosus (SLE), rheumatoid arthritis, Crohn's disease and ulcerative colitis.[patient.info]

  • Vitamin B12 Deficiency

    The symptoms of B12 deficiency include tiredness, light-headedness , rapid heart rate , easy bruising and bleeding, weight loss, bowel upset and sore tongue.[healthdirect.gov.au] peripheral neuropathy, and spinal degeneration.[ncbi.nlm.nih.gov] RESULTS: Prevalence of B12 deficiency among patients with CD was 33% compared with 16% in ulcerative colitis (P 0.0001).[ncbi.nlm.nih.gov]

  • Polyarteritis Nodosa

    After 13 months, all the new ulcers had completely disappeared, and after 7 months the patient remained free of ulcers at a dosage of less than 25 mg/wk ( Figure 3 ).[doi.org] Ulceration was rare. Erythematous or pigmented lesions were present in 54% of patients.[ncbi.nlm.nih.gov] To our knowledge, this is the first case of localised polyarteritis nodosa in an adult with ulceration of the tongue and necrosis at the onset of the disease.[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    bruising Cardiovascular system —causing abnormal heart beat/heart rate, heart failure, high blood pressure (hypertension), and other conditions Gastrointestinal (GI) tract[healthcommunities.com] Chronic alcoholism also increases the risk of stomach upsets, ulcers and pancreatitis.[epainassist.com] Ulcers and gastrointestinal problems High alcohol consumption is linked to alcoholic fatty liver.[medicalnewstoday.com]

  • Amyloidosis

    bruising or bleeding Pancreas - Diabetes Musculoskeletal system - Joint pain or swelling, weakness Skin - Lumps or purple discoloration No one knows what causes amyloidosis[health.harvard.edu] Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[ncbi.nlm.nih.gov] Oesophagogastroduodenoscopy showed ulcerations of oesophagus and duodenum. Biopsies revealed focal amyloid deposition, stained with Congo red.[ncbi.nlm.nih.gov]

  • Multiple Myeloma

    bruising or bleeding – due to low platelet numbers Bleeding from the nose or gums Repeated infections or infections that are hard to get rid of Thirst, nausea, vomiting or[betterhealth.vic.gov.au] […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[radiopaedia.org] New ulcers developed at the site of enoxaparin injection at the right arm (pathergy phenomenon).[ncbi.nlm.nih.gov]

  • Waldenstrom Macroglobulinemia

    The covered platelet cells may not work right, resulting in bleeding and easy bruising. Every year, there are five new cases of macroglobulinemia per 1,000,000 people.[uihc.org] Neuropathy is typically slowly progressive, distal, symmetrical, and sensorimotor.[emedicine.medscape.com] On examination, he was pale and had large ulcers on both lower limbs [Figure 1].[mjdrdypu.org]

  • Chediak Higashi Syndrome

    Chediak-Higashi syndrome (CHS) is a very rare autosomal recessive disorder (gene CHS1/LYST) characterized by partial albinism, recurrent infections, and easy bruising.[ncbi.nlm.nih.gov] peripheral neuropathy and the tendency to develop a life threatening lymphoma like syndrome. 1 Susceptibility to infection from phagocytic dysfunction ranges from mild recurrent[pjms.com.pk] A 14-year-old male C-HS patient was referred to us because of serious periodontal destruction with acute inflamed gingiva and ulcers.[ncbi.nlm.nih.gov]

  • Systemic Lupus Erythematosus

    bruising Anxiety Depression Memory loss[web.archive.org] progressive course of acute demyelinating polyneuropathy have been reported.[emedicine.medscape.com] KEYWORDS: SLE; Ulcerative colitis; coexistence[ncbi.nlm.nih.gov]

  • Secondary Amyloidosis

    bruising or bleeding Pancreas - Diabetes Musculoskeletal system - Joint pain or swelling, weakness Skin - Lumps or purple discoloration No one knows what causes amyloidosis[health.harvard.edu] Amyloid deposition was conspicuous in the transverse colon with numerous penetrating ulcers that were circumferentially scattered.[ncbi.nlm.nih.gov] […] slightly raised, waxy nodules clustered in the armpits, groin, face, neck, or ears; purple discoloration of the skin, bleeding into the skin (purpura) around the eyes and easy[healthcommunities.com]

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