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901 Possible Causes for ectodomain, membrane, of, protein, proteolysis, upregulation

Did you mean: ectodomain, membrane, of, proteus, proteolysis, upregulation

  • Marburg Virus

    This interaction between Keap1 and mVP24 occurs through the Kelch interaction loop (K-Loop) of mVP24 leading to upregulation of antioxidant response element transcription,[] […] clusters to the plasma membrane.[] GP is the first example of a viral glycoprotein with a phosphorylated ectodomain.[] Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection . Science 308 , 1643–1645 (2005) 4. Schornberg, K. et al.[] This is probably through upregulation of tissue factor expression/release from virus-infected monocytes/macrophages.[] These results suggest that subtle conformational changes took place in the ectodomain.[]

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  • Dengue Virus

    Of these, miR-3614-5p was found upregulated in DENV-negative cells and its overexpression reduced DENV infectivity.[] In this report, we demonstrate that NS4A associates with membranes via 4 internal hydrophobic regions, which are all able to mediate membrane targeting of a cytosolic reporter[] Conclusive evidence for the involvement of DC-SIGN in DV infection was obtained by the inhibition of viral infection by anti-DC-SIGN antibodies and by the soluble tetrameric ectodomain[] Evidence of viral capsid dynamics using limited proteolysis and mass spectrometry . J. Biol. Chem. 273 , 673–676 (1998). 33.[] A crystal structure of the soluble ectodomain of E from dengue virus type 2 reveals a hydrophobic pocket lined by residues that influence the pH threshold for fusion.[] DC‐SIGN, dendritic‐cell‐specific ICAM3‐grabbing non‐integrin; sDC‐SIGN, the soluble, tetrameric ectodomain of DC‐SIGN.[]

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  • Influenza

    No significant upregulation was observed in either group of guinea pigs for TNFα, TBK1, IRF5, or IFNγ ( Figure 5 ).[] A challenge faced by these viruses is the trafficking of viral components into and out of the nucleus through the nuclear membrane.[] The conductances of cysteine mutant proteins A30C and G34C were diminished when the reagent was applied to the medium bathing the N-terminal ectodomain.[] Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell 40 , 627–633 (1985). 5. Zebedee, S.L. & Lamb, R.A.[] Secretion of IFNα/β results in the induction of a cellular antiviral response involving the transcriptional upregulation of 100 genes ( 1 ).[] The H18 HA ectodomain was expressed in the HA0 form [13] .[]

    Missing: of proteolysis
  • Hepatitis C Virus

    The p53 wild type could upregulate NGEN-stimulated PTEN expression while R273H mut-p53 showed no similar function.[] […] that occur between proteins and membranes or lipid structures.[] These proteins contain a large N-terminal ectodomain and a C-terminal transmembrane domain, and they assemble as a noncovalent heterodimer.[] Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets . EMBO J. 21 , 3980–3988 (2002). 60. Boulant, S. et al.[] We propose that all proteins that contain amino acids encoded in the 1 ARF be called alternate reading frame proteins (ARFPs) and that specific ARFPs, such as the ARFP/F-protein[] These proteins contain a large N ‐terminal ectodomain and a C ‐terminal transmembrane domain, and they assemble as a noncovalent heterodimer.[]

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  • Bullous Pemphigoid

    Upregulation of interleukin-6 and interleukin-8 was found at both protein and mRNA levels.[] Abstract Linear IgG deposits along the basement membrane of adnexa has been proposed to be useful in the diagnosis of bullous pemphigoid (BP), but no controlled studies have[] It is proposed that autoantibodies directed against the well-defined antigenic site on the BP180 ectodomain may play an initiatory role in subepidermal blister formation in[] Abstract Extracellular proteolysis by the plasminogen/plasmin (Plg/plasmin) system and MMPs is required for tissue injury in autoimmune and inflammatory diseases.[] membranous component.[] Passive transfer of antibodies to the murine BP180 ectodomain triggers a blistering skin disease in mice that closely mimics human BP.[]

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  • Coxsackie Virus

    We propose that certain, as yet unknown factors (such as cytokines) upregulate CAR on human myocardium and that the level of this upregulation of the attachment receptor CAR[] CXADR [plasma membrane] Stable Identifier R-HSA-197912 Type Protein [EntityWithAccessionedSequence] Species Homo sapiens Compartment Synonyms Coxsackievirus and adenovirus[] Nadia Houri, Kuo-Cheng Huang and Josephine Nalbantoglu , The Coxsackievirus and Adenovirus Receptor (CAR) Undergoes Ectodomain Shedding and Regulated Intramembrane Proteolysis[] [bsid125147] PodNet: protein-protein interactions in the podocyte PodNet: protein-protein interactions in the podocyte PodNet is a manually curated network of protein-protein[] Delivery occurred vaginally approximately 24 hours later, following spontaneous rupture of membranes. At birth, both twins showed signs of sepsis.[] In addition to BACE1, CAR is also a substrate for α and γ-secretases, which can liberate the CAR ectodomain and intracellular domain.[]

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  • Porphyromonas Gingivalis

    Insertion of IS1598 into the nrdD-like gene promoter region may be related to the phenotypic differences in virulence among P. gingivalis strains through upregulation of the[] These results suggest that P. gingivalis accomplishes its internalization utilizing membrane lipid raft and cytoskeletal functions of the target cells.[] Author information 1 From the Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom. 2 the Proteolysis[] In addition, FimC and FimD bound to fibronectin and type 1 collagen, whereas FimE failed to interact with these matrix proteins.[] Among the genes highly upregulated by the nonencapsulated PgC strain were ones coding for cytokines and chemokines.[] In the present study, we addressed this issue using fluorescent beads coated with bacterial membrane vesicles (MVs) that retain surface components of P. gingivalis.[]

    Missing: ectodomain of
  • Ebola Virus

    Cellular RNA was analyzed by real-time PCR for transcriptional upregulation of TNF-α, IL-6, IL-8, and IL-1 beta.[] Progeny virions bud from the plasma membrane of infected cells, suggesting that phosphatidylserine is likely flipped to the outer leaflet of the plasma membrane in infected[] Mechanistically, the maximal NF-κB activation by GP, VP40, and BST2 together requires the ectodomain cysteines needed for BST2 dimerization, the putative BST2 tetramerization[] Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection . Science 308 , 1643–1645 (2005) 4. Schornberg, K. et al.[] Cells that lacked the protein remained unharmed after exposure to the virus in the laboratory.[] Five monoclonal antibodies (mAbs) against the TIM-1 ectodomain were assessed for their ability to inhibit EBOV GP ΔO pseudovirion binding to Vero cells.[]

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  • Human Herpesvirus 8

    Upregulation of ATF4 promotes HHV-8 infection, whereas its silencing decreases virus replication, transcription and antigen expression.[] KSHV Entry and Trafficking in Target Cells—Hijacking of Cell Signal Pathways, Actin and Membrane Dynamics. Viruses 2016 , 8 , 305.[] The K1 gene of HHV-8 is expressed in tumor cells as a transmembrane protein with an immunoglobulin-like domain in its ectodomain and an immunoreceptor tyrosine-based activation[] The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.[] […] response signaling in addition to enhancing viral protein folding.[] The recombinantly expressed hemagglutinin-tagged ectodomain of EphA2 (EphA2-HA) was incubated with precleared supernatant from BC3 cells that were either induced to produce[]

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  • Candida Albicans

    We found that a hyperactive Mrr1, which confers fluconazole resistance by upregulating the multidrug efflux pump MDR1 and other genes, also causes FLU1 overexpression.[] Berberine also caused membrane depolarization and lipid peroxidation of membrane constituents indicating its direct effect on the membrane.[] Monk , Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a d‐octapeptide derivative inhibitor , Molecular Microbiology , 85 , 4 , (747[] Our results indicate that single amino acid modifications drastically impact both proteolysis at the modification sites and the overall level of proteolysis of the peptide[] […] interacting proteins ( Kerppola 2009 ).[] However, a number of the genes upregulated in all conditions in this study have been shown by others to be upregulated in certain filamentation conditions.[]

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