Create issue ticket

901 Possible Causes for ectodomain, membrane, of, protein, proteolysis, upregulation

Did you mean: ectodomain, membrane, of, proteus, proteolysis, upregulation

  • Marburg Virus

    This interaction between Keap1 and mVP24 occurs through the Kelch interaction loop (K-Loop) of mVP24 leading to upregulation of antioxidant response element transcription,[ncbi.nlm.nih.gov] […] clusters to the plasma membrane.[ncbi.nlm.nih.gov] GP is the first example of a viral glycoprotein with a phosphorylated ectodomain.[ncbi.nlm.nih.gov] Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection . Science 308 , 1643–1645 (2005) 4. Schornberg, K. et al.[doi.org] This is probably through upregulation of tissue factor expression/release from virus-infected monocytes/macrophages.[ncbi.nlm.nih.gov] These results suggest that subtle conformational changes took place in the ectodomain.[ncbi.nlm.nih.gov]

    Missing: of
  • Dengue Virus

    Of these, miR-3614-5p was found upregulated in DENV-negative cells and its overexpression reduced DENV infectivity.[ncbi.nlm.nih.gov] In this report, we demonstrate that NS4A associates with membranes via 4 internal hydrophobic regions, which are all able to mediate membrane targeting of a cytosolic reporter[ncbi.nlm.nih.gov] Conclusive evidence for the involvement of DC-SIGN in DV infection was obtained by the inhibition of viral infection by anti-DC-SIGN antibodies and by the soluble tetrameric ectodomain[ncbi.nlm.nih.gov] Evidence of viral capsid dynamics using limited proteolysis and mass spectrometry . J. Biol. Chem. 273 , 673–676 (1998). 33.[doi.org] A crystal structure of the soluble ectodomain of E from dengue virus type 2 reveals a hydrophobic pocket lined by residues that influence the pH threshold for fusion.[ncbi.nlm.nih.gov] DC‐SIGN, dendritic‐cell‐specific ICAM3‐grabbing non‐integrin; sDC‐SIGN, the soluble, tetrameric ectodomain of DC‐SIGN.[doi.org]

    Missing: of
  • Influenza

    No significant upregulation was observed in either group of guinea pigs for TNFα, TBK1, IRF5, or IFNγ ( Figure 5 ).[dx.doi.org] A challenge faced by these viruses is the trafficking of viral components into and out of the nucleus through the nuclear membrane.[ncbi.nlm.nih.gov] The conductances of cysteine mutant proteins A30C and G34C were diminished when the reagent was applied to the medium bathing the N-terminal ectodomain.[doi.org] Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell 40 , 627–633 (1985). 5. Zebedee, S.L. & Lamb, R.A.[dx.doi.org] Secretion of IFNα/β results in the induction of a cellular antiviral response involving the transcriptional upregulation of 100 genes ( 1 ).[doi.org] The H18 HA ectodomain was expressed in the HA0 form [13] .[doi.org]

    Missing: of proteolysis
  • Hepatitis C Virus

    The p53 wild type could upregulate NGEN-stimulated PTEN expression while R273H mut-p53 showed no similar function.[ncbi.nlm.nih.gov] […] that occur between proteins and membranes or lipid structures.[ncbi.nlm.nih.gov] These proteins contain a large N-terminal ectodomain and a C-terminal transmembrane domain, and they assemble as a noncovalent heterodimer.[ncbi.nlm.nih.gov] Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets . EMBO J. 21 , 3980–3988 (2002). 60. Boulant, S. et al.[doi.org] We propose that all proteins that contain amino acids encoded in the 1 ARF be called alternate reading frame proteins (ARFPs) and that specific ARFPs, such as the ARFP/F-protein[ncbi.nlm.nih.gov] These proteins contain a large N ‐terminal ectodomain and a C ‐terminal transmembrane domain, and they assemble as a noncovalent heterodimer.[doi.org]

    Missing: of
  • Bullous Pemphigoid

    Upregulation of interleukin-6 and interleukin-8 was found at both protein and mRNA levels.[ncbi.nlm.nih.gov] Abstract Linear IgG deposits along the basement membrane of adnexa has been proposed to be useful in the diagnosis of bullous pemphigoid (BP), but no controlled studies have[ncbi.nlm.nih.gov] It is proposed that autoantibodies directed against the well-defined antigenic site on the BP180 ectodomain may play an initiatory role in subepidermal blister formation in[ncbi.nlm.nih.gov] Abstract Extracellular proteolysis by the plasminogen/plasmin (Plg/plasmin) system and MMPs is required for tissue injury in autoimmune and inflammatory diseases.[ncbi.nlm.nih.gov] membranous component.[ncbi.nlm.nih.gov] Passive transfer of antibodies to the murine BP180 ectodomain triggers a blistering skin disease in mice that closely mimics human BP.[ncbi.nlm.nih.gov]

    Missing: of
  • Coxsackie Virus

    We propose that certain, as yet unknown factors (such as cytokines) upregulate CAR on human myocardium and that the level of this upregulation of the attachment receptor CAR[doi.org] CXADR [plasma membrane] Stable Identifier R-HSA-197912 Type Protein [EntityWithAccessionedSequence] Species Homo sapiens Compartment Synonyms Coxsackievirus and adenovirus[reactome.org] Nadia Houri, Kuo-Cheng Huang and Josephine Nalbantoglu , The Coxsackievirus and Adenovirus Receptor (CAR) Undergoes Ectodomain Shedding and Regulated Intramembrane Proteolysis[doi.org] [bsid125147] PodNet: protein-protein interactions in the podocyte PodNet: protein-protein interactions in the podocyte PodNet is a manually curated network of protein-protein[ncbi.nlm.nih.gov] Delivery occurred vaginally approximately 24 hours later, following spontaneous rupture of membranes. At birth, both twins showed signs of sepsis.[ncbi.nlm.nih.gov] In addition to BACE1, CAR is also a substrate for α and γ-secretases, which can liberate the CAR ectodomain and intracellular domain.[doi.org]

    Missing: of
  • Porphyromonas Gingivalis

    Insertion of IS1598 into the nrdD-like gene promoter region may be related to the phenotypic differences in virulence among P. gingivalis strains through upregulation of the[ncbi.nlm.nih.gov] These results suggest that P. gingivalis accomplishes its internalization utilizing membrane lipid raft and cytoskeletal functions of the target cells.[doi.org] Author information 1 From the Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom. 2 the Proteolysis[ncbi.nlm.nih.gov] In addition, FimC and FimD bound to fibronectin and type 1 collagen, whereas FimE failed to interact with these matrix proteins.[ncbi.nlm.nih.gov] Among the genes highly upregulated by the nonencapsulated PgC strain were ones coding for cytokines and chemokines.[ncbi.nlm.nih.gov] In the present study, we addressed this issue using fluorescent beads coated with bacterial membrane vesicles (MVs) that retain surface components of P. gingivalis.[ncbi.nlm.nih.gov]

    Missing: ectodomain of
  • Ebola Virus

    Cellular RNA was analyzed by real-time PCR for transcriptional upregulation of TNF-α, IL-6, IL-8, and IL-1 beta.[doi.org] Progeny virions bud from the plasma membrane of infected cells, suggesting that phosphatidylserine is likely flipped to the outer leaflet of the plasma membrane in infected[ncbi.nlm.nih.gov] Mechanistically, the maximal NF-κB activation by GP, VP40, and BST2 together requires the ectodomain cysteines needed for BST2 dimerization, the putative BST2 tetramerization[ncbi.nlm.nih.gov] Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection . Science 308 , 1643–1645 (2005) 4. Schornberg, K. et al.[doi.org] Cells that lacked the protein remained unharmed after exposure to the virus in the laboratory.[nytimes.com] Five monoclonal antibodies (mAbs) against the TIM-1 ectodomain were assessed for their ability to inhibit EBOV GP ΔO pseudovirion binding to Vero cells.[doi.org]

    Missing: of
  • Human Herpesvirus 8

    Upregulation of ATF4 promotes HHV-8 infection, whereas its silencing decreases virus replication, transcription and antigen expression.[eprints.unife.it] KSHV Entry and Trafficking in Target Cells—Hijacking of Cell Signal Pathways, Actin and Membrane Dynamics. Viruses 2016 , 8 , 305.[doi.org] The K1 gene of HHV-8 is expressed in tumor cells as a transmembrane protein with an immunoglobulin-like domain in its ectodomain and an immunoreceptor tyrosine-based activation[cancerres.aacrjournals.org] The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.[doi.org] […] response signaling in addition to enhancing viral protein folding.[ncbi.nlm.nih.gov] The recombinantly expressed hemagglutinin-tagged ectodomain of EphA2 (EphA2-HA) was incubated with precleared supernatant from BC3 cells that were either induced to produce[doi.org]

    Missing: of
  • Candida Albicans

    We found that a hyperactive Mrr1, which confers fluconazole resistance by upregulating the multidrug efflux pump MDR1 and other genes, also causes FLU1 overexpression.[ncbi.nlm.nih.gov] Berberine also caused membrane depolarization and lipid peroxidation of membrane constituents indicating its direct effect on the membrane.[bmccomplementalternmed.biomedcentral.com] Monk , Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a d‐octapeptide derivative inhibitor , Molecular Microbiology , 85 , 4 , (747[doi.org] Our results indicate that single amino acid modifications drastically impact both proteolysis at the modification sites and the overall level of proteolysis of the peptide[ncbi.nlm.nih.gov] […] interacting proteins ( Kerppola 2009 ).[doi.org] However, a number of the genes upregulated in all conditions in this study have been shown by others to be upregulated in certain filamentation conditions.[doi.org]

    Missing: of