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60 Possible Causes for Eczema, Vacuolation of Granular Layer

  • Ichthyosis Vulgaris

    Abstract We recently reported two common filaggrin (FLG) null mutations that cause ichthyosis vulgaris and predispose to eczema and secondary allergic diseases.[] Histopathologically, the cells of the granular cell layer and the upper part of stratum spinosum develop intracytoplasmic vacuoles, an increased number and size of keratohyaline[] Mutations in the gene encoding filaggrin (FLG) have been identified as the cause of ichthyosis vulgaris and have been shown to be major predisposing factors for atopic eczema[]

  • Glucagonoma

    He was diagnosed with eczema.[] A skin biopsy performed on a peritibial lesion showed a spongiotic epidermis with vacuolization of the granular layer and presence of necrotic keratinocytes in the horny layer[] In a few cases rash has had the appearance of eczema craquele, or may resemble chemical burns.[]

  • Polymorphic Photodermatitis

    Infections – skin infections like bacterial, viral or fungal can lead to eczema or make the existing eczema worse.[] Keratinocytes in the granular layer are vacuolated due to being infected with the wart virus. si Common warts.[] (Medical Encyclopedia) Dyshidrotic eczema (Medical Encyclopedia) Nummular eczema (Medical Encyclopedia) Seborrheic dermatitis (Medical Encyclopedia) [ Read More ] Rashes[]

  • Pityriasis Rubra Pilaris

    Initial missed diagnoses include psoriasis, contact dermatitis, eczema/spongiotic dermatitis, seborrheic de...[] Hyperkeratosis, parakeratosis, preserved granular layer and psoriasiform hyperplasia were showed in all biopsies.[] This is usually accompanied by eczema of some type. Classical juvenile onset PRP typically develops between 5 and 10, and follows an infection in most cases.[]

  • Condyloma Acuminatum

    High-magnification view of the granular layer demonstrates coarse hyaline granules with scattered koilocytic changes (hyperchromatic nuceli with vacuolization).[]

  • Methylmalonic Acidemia

    Multiple hemorrhagic foci were noted in the cerebellum, predominantly the granular layers. The lymphoid tissue in the spleen and the thymus was hypoplastic.[] Myelinated nerve fibers in the brainstem were spongy or vacuolated, whereas peripheral myelin sheaths of cranial nerves were intact.[]

  • Molluscum Contagiosum

    An association between the presence of atopic eczema (AE) and MC has been shown, but the subsequent risk of developing MC in children with a diagnosis of AE is not known.[] The nucleus becomes compressed at the level of the granular cell layer, and the molluscum bodies lose their internal structural markings.[] It is unknown if the concurrent high incidence of eczema and MC is related, and this association deserves further investigation.[]

  • Erythema Palmaris Hereditarium

    Topical and special varieties Eczema of children Eczema of scalp Eczema of face Eczema of lips Eczema of nostrils Eczema of ears Eczema of eyelids Eczema of beard Eczema[] The granular cells are small cytoplasmic vacuoles.[] (Dyshidrosis); (Pompholyx); (Vesicular Palmoplantar Eczema); (Vesicular Eczema of Palms & Soles) Dyskeratosis Congenital (Zinsser-Engman-Cole Syndrome); (Zinsser-Cole-Engman[]

  • Ichthyosis

    […] study involves a series of research and development projects targeted at two of the most common chronic diseases affecting children: asthma and atopic dermatitis (AD, or eczema[] Histopathologically, the cells of the granular cell layer and the upper part of stratum spinosum develop intracytoplasmic vacuoles, an increased number and size of keratohyaline[] […] or binucleated cells in the granular and suprabasal layers, although no granular degeneration is seen. 67, 68 Characteristically, the electron microscopic study of both normal‐looking[]

  • Bullous Erythroderma Ichthyosiformes

    It is differentiated from psoriasis by the spongiosis and vesicle formation, but often cannot be differentiated from eczema or other low grade inflammations. Treatment.[] These become mature corps ronds by further vacuolization when in the granular layer.[] […] is dry with fine white scale Affects abdomen, arms and legs, sparing creases of arms and legs Causes keratosis pilaris Palms are excessively lined Associated with atopic eczema[]

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