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157 Possible Causes for Edema, Mutation in the Hereditary Hemochromatosis Gene

  • Congestive Heart Failure

    Peripheral edema: Edema develops in the feet in ambulatory patients and sacral edema in bed bound patients.[symptoma.com] The actuarial survival rates of persons who are homozygous for the mutation of the hemochromatosis gene C282Y have been reported to be 95%, 93%, and 66%, at 5, 10, and 20[doi.org] edema in patients who in fact have cardiogenic edema.[emedicine.com]

  • Heart Failure

    edema in patients who in fact have cardiogenic edema.[emedicine.com] The actuarial survival rates of persons who are homozygous for the mutation of the hemochromatosis gene C282Y have been reported to be 95%, 93%, and 66%, at 5, 10, and 20[doi.org] Both systolic and diastolic heart failure can cause edema (fluid) to build up in the lungs and the rest of the body.[jama.ama-assn.org]

  • Liver Cirrhosis

    RESULTS: Villous edema was observed in 131 patients (36%), and severe lesions were found in 71 (20%).[ncbi.nlm.nih.gov] We herein report the assessment of glycemic control in a 41-year-old man with dehydrated hereditary stomatocytosis and a PIEZO1 gene mutation complicated by diabetes mellitus[ncbi.nlm.nih.gov] After therapy, CE findings among the 24 cases were as follows: villous edema (19 cases); erythema (17 cases); angioectasia (16 cases); erosions (12 cases); and EVs (9 cases[ncbi.nlm.nih.gov]

  • Cryptogenic Cirrhosis

    CARDIAC CIRRHOSIS Clinic a l featu r es · Mild jaundice · Liver dysfunction · Hepatomegaly – firm, non tender • *Ascites · Peripheral edema · Oesophageal bleeding · Encephalopathy[medicscientist.com] Because of the discovery of the candidate gene (HFE) for hereditary hemochromatosis, we may now be able to screen high-risk patient populations for the abnormal mutation ([ncbi.nlm.nih.gov] Affected individuals can experience fatigue, weakness, loss of appetite, weight loss, nausea, swelling ( edema ), enlarged blood vessels, and yellowing of the skin and whites[ghr.nlm.nih.gov]

  • Hemochromatosis

    The pregnancy may be complicated by intrauterine growth retardation, oligohydramnios, placental edema, or sometimes polyhydramnios. 6 , ,7 Illness usually is evident within[pediatrics.aappublications.org] Hereditary hemochromatosis can be divided into HFE- and non-HFE-related based on genetic mutations in different genes.[ncbi.nlm.nih.gov] From Pathology Education Instructional Resource Clinical Summary This 61-year-old female was first admitted to the hospital because of ascites and pedal edema.[peir.path.uab.edu]

  • Restrictive Cardiomyopathy

    A 75-year-old man was admitted for evaluation of marked edema and jaundice. Serum total bilirubin was elevated above 20 mg/dl.[ncbi.nlm.nih.gov] Cardiac Hemochromatosis Hereditary hemochromatosis (HH) is caused by increased absorption of dietary iron, which accumulates in various organs, leading to their dysfunction[circres.ahajournals.org] It usually manifests as a progressive heart failure with fatigue, exertional dyspnea and edema.[symptoma.com]

  • Fatty Liver

    […] the abdomen Abdominal pain Loss of appetite or weight loss Nausea Weakness Jaundice (yellowing of the skin and the whites of the eyes) Swelling of the abdomen and legs (edema[my.clevelandclinic.org] […] is mutated in patients with hereditary hemochromatosis.[doi.org] Later, edema of the extremities and general anasarca take place. Diagnosis .[henriettes-herb.com]

  • Hemochromatosis-related Cardiomyopathy

    Varying degrees of degeneration, edema, and fibrosis of the myocardium can be seen. Electrocardiographic changes and even cardiac failure may occur.[histopathology-india.net] Classic hereditary hemochromatosis is caused by mutations of the HFE gene.[rarediseases.org] […] life by conventional therapy and repeated phlebotomies.Case ReportA 35-year-old single man was admitted to the hospital in January, 1966, because of anorexia, weight gain, edema[nejm.org]

  • Wilson Disease

    On physical examination: slight jaundice, edema of lower extremities, skin purpuric rash, enlarged abdomen, dry skin. She had no hepatomegaly and no splenomegaly.[ncbi.nlm.nih.gov] Mutations in genes encoding ATPase, Cu transporting, beta polypeptide (ATP7B) and hemochromatosis (HFE) or several non-HFE genes are considered to be causative for WD and[ncbi.nlm.nih.gov] Signs and symptoms of the disease may include: Abdominal pain and bloating Anxiety and depression Edema or fluid build up in legs and feet Fatigue Jaundice Kayser-Fleischer[news-medical.net]

  • Iron Deficiency

    At necropsy, these pigs will have pallor, a thin-walled heart, and edema of the lungs, muscles and connective tissues.[vetmed.iastate.edu] A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet. 1996;13:399–408. PubMed CrossRef Google Scholar 8.[doi.org] In later stages, ankle edema may be present. Note any breathlessness or rapid breathing.[medical-dictionary.thefreedictionary.com]

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